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  • 1
    Electronic Resource
    Electronic Resource
    Development and in vitro Characterization of a Cationized Monoclonal Antibody against βA4 Protein: A Potential Probe for Alzheimer's Disease (1994)
    s.l. : American Chemical Society
    Bioconjugate chemistry 5 (1994), S. 119-125 
    Details
    ISSN: 1520-4812
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bc00026a003
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  • 2
    Electronic Resource
    Electronic Resource
    2-[(2-Pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K+-ATPase inhibitors (1992)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 35 (1992), S. 438-450 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00081a004
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  • 3
    Electronic Resource
    Electronic Resource
    Rovibrational coupling in the S1 excited state of 1-methylindole (1993)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 99 (1993), S. 67-79 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We have undertaken an extensive study of the spectroscopy and dynamics of the S1–S0 transition in jet-cooled 1-methylindole and 1-methyl(d3)indole. The energy-resolved fluorescence decays resulting from picosecond excitation of S1 vibrational modes display unusual quantum interference effects which have been attributed to the excitation of a large number of quasidegenerate states even at relatively low levels of vibrational excitation. This has been attributed to rovibrational coupling in which the selection rules are much less restrictive than is normally the case with rigid planar molecules. A significant rotational temperature dependence of the vibrational dynamics has been measured which serves to corroborate this model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.465740
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  • 4
    Electronic Resource
    Electronic Resource
    Vibrational predissociation in S1 indole van der Waals clusters (1991)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 95 (1991), S. 6261-6270 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The excited state dynamics of the indole(Ar)1, indole(d1)(Ar)1, indole(Ar)2, and indole(CH4)1 van der Waals clusters have been investigated in a free jet expansion. Excited state vibrational frequencies were determined using multiphoton ionization and fluorescence excitation spectroscopy. Time resolved emission spectroscopic techniques were used to determine vibrational predissociation rates and product state distributions. All of the clusters were found to predissociate when excited with sufficient vibrational energy in the S1 state. The predissociation dynamics were found to be consistent with a serial model in which energy transfer from the indole skeletal modes to the van der Waals modes precedes the dissociation step. The density of van der Waals vibrational states was found to be the most important factor in determining the predissociation dynamics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.461547
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  • 5
    Electronic Resource
    Electronic Resource
    Nicotine withdrawal versus other drug withdrawal syndromes: similarities and dissimilarities (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction 89 (1994), S. 0 
    Details
    ISSN: 1360-0443
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Many of the symptoms of nicotine withdrawal are similar to those of other drug withdrawal syndromes: anxiety, awakening during sleep, depression, difficulty concentrating, impatience, irritability/anger and restlessness. Slowing of the heart rate and weight gain are distinguishing features of tobacco withdrawal. Although nicotine withdrawal may not produce medical consequences, it lasts for several weeks and can be severe in some smokers. Like most other drug withdrawals, nicotine withdrawal is time-limited, occurs in non-humans, is influenced by instructions/expectancy and abates with replacement therapy and gradual reduction. Unlike some other drug withdrawal syndromes, protracted, neonatal or precipitated withdrawal does not occur. Whether nicotine withdrawal is associated with tolerance, acute physical dependence, greater duration and intensity of use, rapid reinstatement, symptom stages, cross-dependence with other nicotine ligands, reduction by non-pharmacological interventions and genetic influences is unclear. Whether nicotine withdrawal plays a major role in relapse to smoking has not been established but this is also true for other drug withdrawal syndromes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1360-0443.1994.tb03744.x
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  • 6
    Electronic Resource
    Electronic Resource
    Detection of interleukin-8 and matrix metalloproteinases transcripts in healthy and diseased gingival biopsies by RNA/PCR (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.1993.tb02114.x
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  • 7
    Electronic Resource
    Electronic Resource
    Circles in (B, N)-groups (1973)
    Springer
    Mathematische Zeitschrift 130 (1973), S. 249-253 
    Details
    ISSN: 1432-1823
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01246622
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  • 8
    Electronic Resource
    Electronic Resource
    Hepatic and extrahepatic metabolism of the psychotropic drugs, chlorpromazine, imipramine, and imipramine-N-oxide (1971)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 268 (1971), S. 334-347 
    Details
    ISSN: 1432-1912
    Keywords: Extrahepatic Drug Metabolism ; Chlorpromazine ; Imipramine ; Imipramine-N-oxide ; Total Hepatectomy ; Liver Perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The metabolism of chlorpromazine (CPZ), imipramine (IP), and imipramine-N-oxide (IPNO) was studied in microsomal preparations of various rat tissues in vitro and in the isolated perfused liver. A technique for a total hepatectomy in the rat has been developed, allowing estimations of extrahepatic and hepatic drug metabolism in vivo. CPZ is converted to its sulfoxide and other metabolites in the liver and, to a minor degree, in many extrahepatic organs except brain and skin. Whole blood of several species shows a remarkable sulfoxidizing activity which can be traced to the hemoglobin and is likely to represent a heme catalysis. IP is metabolized in the liver in vitro and, to a very minor extent, in lung and kidney. Blood, brain and many other extrahepatic tissues do not metabolize this drug in vitro. However, gastro-intestinal contents of rats and humans demethylate IP to Desmethylimipramine (DMI). This is likely to be the reason for a hepatic/ extrahepatic metabolism ratio of 53/47 measured in sham operated and totally hepatectomized rats. The occurrence of IPNO metabolism in extrahepatic tissues in vitro was confirmed in vivo with hepatectomized rats. The hepatic/extrahepatic ratio is 10/90. The course of IPNO metabolism, compartmental distribution and biliary excretion of the drug and its metabolites was studied in rat liver perfusion experiments. Immediate partial conversion of IPNO to IP and DMI by hemoglobin was confirmed by perfusion experiments without the liver, and liver perfusions with hemoglobin-free perfusates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00997266
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  • 9
    Electronic Resource
    Electronic Resource
    Uptake, subcellular distribution, and transfer processes of imipramine and its metabolites formed in rat liver perfusion systems (1974)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 284 (1974), S. 339-352 
    Details
    ISSN: 1432-1912
    Keywords: Hepatic Uptake Mechanisms ; Drug Metabolism ; Subcellular Distribution ; Drug Translocations ; Biliary Excretion ; Imipramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pharmacokinetic processes have been studied using a recirculating rat liver perfusion system. Imipramine and its major metabolites have been determined at various times up to 3 h in perfusate, liver, bile and subcellular liver fractions. Imipramine undergoes a rapid hepatic uptake, the initial extraction being close to 100%. Most of the unchanged drug is then localized in the microsomal fraction. Metabolism is not limited by uptake and follows the pathways known from previous work. Like imipramine, its lipophilic metabolite, desmethylimipramine is bound to microsomes. Its concentration ratios, endoplasmic reticulum/cytosol and liver/perfusate, are around 200. In contrast, the polar glucuronides are easily released from the ER, their site of formation, into the cytosol and presumably from there excreted into the bile. A smaller amount of the glucuronides is increted into the perfusate where they reach a steady state level. Analogous experiments with a non-recirculating perfusion system yielded comparable results except for a more rapid imipramine uptake. The results obtained in this study suggest that the pharmacokinetics of many drugs with high apparent volumes of distribution may be largely governed by intracellular binding of lipophilic compounds and translocation processes of polar metabolites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00504703
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  • 10
    Electronic Resource
    Electronic Resource
    Die Dünnschichtchromatographie der Aminosäuren im Urin (1970)
    Springer
    Journal of molecular medicine 48 (1970), S. 682-688 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Methods for thin-layer chromatography of urinary amino acids on commercially available procoated plates of micro-crystalline cellulose are presented. The urine is desalted by passing it through columns containing Amberlite CG 120 I. The amino acids are eluted by a solution of 5 per cent ammonia. The eluate is taken to dryness and dissolved in such an amount of water that 1 µl corresponds to 1 µg of creatinine. 1 µl is spotted to plates (10×10 cm) by micro pipets. Every urine is developed two-dimensionally by two solvent pairs. First pair: Ethanol-H2O (83:17), first direction, three times developed up to 8 cm, tert-Butanolmethylethylketone-NH3-diethylamine-H2O (35:35:10:0,4:20), second direction, once developed up to 8 cm. Second pair: n-Butanol-acetone-glacial acetic acid-H2O (35:35:10:20), first direction, phenol-formic acid (15 per cent) (250 g+83 ml), second direction, once developed up to 8 cm. Using these solvent pairs it is possible to separate most of the important urinary amino acids and diagnose or suspect most of the known metabolic disorders with a disturbed urinary excretion of amino acids. Phosphoethanolamine, S-sulphocysteine and taurine are lost by desalting the urine. Special problems of detecting and locating some amino acids are discussed.
    Notes: Zusammenfassung Es werden Methoden zur Dünnschichtchromatographie der Harnaminosäuren auf mikrokristalliner Cellulose angegeben. Vor der dünnschichtchromatographischen Trennung wird der Urin (Amberlite CG 120 I, H+-Form; Elution mit 5% igem NH3) entsalzt. Nach Einengen des Eluats zur Trockne und Lösung des Rückstandes in einer auf den Kreatiningehalt des Urins bezogenen Menge Wasser wird der Urin auf Cellulose-Fertigplatten der Fa. Merck AG. aufgetragen. Die Plattengröße beträgt 10×10 cm. Durch Verwendung von zwei Fließmittelpaaren ist es möglich, bei den meisten der bekannten Stoffwechselkrankheiten mit vermehrter Aminosäure-Ausscheidung eine Diagnose oder eine Verdachtsdiagnose zu stellen. Ausnahmen sind lediglich die Hypophosphatasie, der Sulfitoxydase-Mangel und die Taurinurie, da die bei diesen Störungen vermehrt ausgeschiedenen Aminosäuren Phosphoäthanolamin, S-Sulfo-l-cystein und Taurin bei der Entsalzung verloren gehen. Auf spezielle Probleme des Nachweises einzelner Aminosäuren wird eingegangen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01493814
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