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  • 1990-1994  (3)
  • 1970-1974
  • Chemistry  (2)
  • Multi-drug resistance  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas (1994)
    Springer
    Virchows Archiv 425 (1994), S. 133-138 
    Details
    ISSN: 1432-2307
    Keywords: Multi-drug resistance ; P-glycoprotein Human glioma ; Endothelial cells ; Blood-brain barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The P-glycoprotein (P-Gp) encoded by the human multidrug-resistance gene MDR1 has been suggested to play certain roles in the blood-brain barrier (BBB). However, the detailed mechanism of the activity of P-Gp in multidrug-resistance (MDR) remains unclear in human glioma. We examined the localization of P-Gp in human glioma by immunohistochemical (IHC) and immunoelectron microscopic (IEM) methods with anti P-Gp monoclonal antibodies (C219, MRK16). We also examined MDR1 expression in primary glioma and xenografts by reverse transcription-polymerase chain reaction (RT-PCR) with human MDR1-specific primers. The IHC study showed no P-Gp expression on tumour cells but it was present on capillary endothelial cells and IEM analysis showed definitive localization on their luminal surface. MDR1 gene expression was detected in eight primary glioma and three normal brain specimens by RT-PCR, but not in glioma xenografts. The lack of MDR1 expression in these cells appears to be a consequence of the replacement of the original human stroma, including blood vessels, by murine stroma in glioma xenografts. The unique distribution of P-Gp on the capillary blood vessels was confirmed in human glioma by the results of immunohistochemical and molecular biological studies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230349
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  • 2
    Electronic Resource
    Electronic Resource
    Preparation and properties of polyborosiloxanes as precursors for borosilicate formation of SiO2-B2O3 gel fibers and oxides by the sol-gel method using tetraacetoxysilane and boron tri-n-butoxide (1994)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 1049-1056 
    Details
    ISSN: 0887-624X
    Keywords: tetraacetoxysilane ; boron tri-n-butoxide ; sol-gel method ; condensation ; SiO2 - B2O3 gel fibers ; borosilicates ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Formation of SiO2-B2O3 gel fibers and oxides was investigated by the sol-gel method using tetraacetoxysilane (TAS) and boron tri-n-butoxide (BTB). Low molecular weight borosiloxanes (BS) were formed by the reaction of TAS with BTB in THF. Partial alkoxylation and hydrolysis of BS followed by further condensation of the resulting polymer (PBS) solutions led to the formation of highly polymerized polyborosiloxanes (HPBS) with good spinnability. Gel fibers were obtained by dry spinning of HPBS. The compositions of PBS and gels were not consistent with that in feed. Heat treatment of the gels, however, provided SiO2-B2O3 oxides with compositions almost compatible with those of the gels. © 1994 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pola.1994.080320606
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Oxidation study of 3d transition metals (Cr, Fe, Co and Ni) and rare earth (Tb): Application to auger depth profiling of magneto-optical disk (1994)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 22 (1994), S. 14-17 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Through the oxygen exposure experiments on 3d transition metals (Cr, Fe, Co and Ni) and rare earth (Tb), we studied the initial oxidation by means of Auger peak-to-peak height (APPH) method. Based on the results obtained, a simple technique using the ratio of APPH was applied to the Auger depth profile analysis of magneto-optical disk (MOD). It was clearly indicated that the preferential oxidation of Tb occurred only at the lower interface between the TbFeCo and metal-oxide layers, and this technique can be used to obtain the chemical information about the interface oxidation in Auger depth profiling.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740220106
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    Paper (German National Licenses)
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