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  • 1970-1974  (5)
  • 1
    Electronic Resource
    Electronic Resource
    CALCIUM MOVEMENTS IN BRAIN SLICES IN LOW SODIUM OR CALCIUM MEDIA (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Movement of 45Ca into and out of cerebral slices in vitro was altered by incubation in Na-free medium or in the presence of ouabain. 45Ca uptake into the ‘non-inulin’ space was more than doubled in slices that were losing Na into Na-deficient media. Replacement of Na in the incubation medium by choline chloride reduced the efflux of 45Ca into Ca-free medium. In the presence of ouabain (10-4M), the rate of efflux was also reduced. NaCN or NaCN plus ethacrynic acid increased the rate of 45Ca efflux. The data are compatible with a sodium-calcium exchange mechanism in cerebral slices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1972.tb01294.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    SUBCELLULAR FRACTIONATION OF POSTMORTEM BRAIN (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Procedures used to separate subcellular organelles from fresh brain were applied to brains which had been removed from guinea pigs (1) immediately after death; (2) after the dead animal was maintained at room temperature for 3 h, followed by 16–17 h at 4°C; or (3) after the dead animal was maintained for 19–20 h at room temperature. Subcellular fractionation of the brains in 0.32 M sucrose was followed by discontinuous density gradient centrifugation of the crude mitochondrial fraction. After overnight storage of brains at room temperature, there was a moderate shift in succinate dehydrogenase activity from sub-fraction C (mitochondria) to subfraction B (synaptosomes). There was little change in the distribution of galactolipid among particulate subfractions. There was little change in distributions of monoamine oxidase or acetylcholinesterase activities. Under the less extreme postmortem conditions, there were no shifts in the subcellular distributions of brain enzymes. Ultrastructural changes were much more profound and consisted of losses of identifiable mitochondria and synaptosomes and a progressive increase in very dense bodies. Our results suggest that in spite of the marked morphological changes, meaningful separation of subcellular organelles can be achieved with postmortem tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb12145.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    SUBCELLULAR DISTRIBUTION OF CEREBRAL CHOLE-STANOL IN CEREBROTENDINOUS XANTHOMATOSIS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Frozen frontal lobe from a patient with cerebrotendinous xanthomatosis and two control specimens were separated by differential centrifugation into subcellular fractions. The fractions were differentiated by their electron microscopic appearance, by their succinate dehydrogenase and acetylcholinesterase activities and by their galactolipid contents. Free cholestanol was present in largest amounts in the myelin fraction and was also found in each subcellular fraction prepared from the cerebrotendinous xanthomatosis brain. Thus, in this condition, cholestanol storage is a property of myelin and probably also of other brain membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb11968.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    MOVEMENTS OF CALCIUM AND OTHER CATIONS IN ISOLATED CEREBRAL TISSUES (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Slices of guinea pig cerebral cortex were incubated in bicarbonate- or trisbuffered media. Influx of 45Ca2 +, 54Mn2 +, 133Ba2+ or 90Sr2+ was determined at intervals following addition of the cardiac glycoside, ouabain, to the medium. After incubation for 30 min in the presence of 45Ca2+ and in the absence of ouabain, about 40 per cent of the slice calcium became labelled. Ouabain (01 I″M) markedly increased 45Ca2 + content, as well as the content of unlabelled Ca2 +. Mg2+ and Na+ levels also rose while K+ content dropped at a more rapid rate. Ouabain also brought about increased uptake of 90Sr2+, 133Ba2 + and 54Mn2 +. Lowering the Na+ content of the media prevented the effects of ouabain and brought about an increase in calcium content of brain slices. Addition of 2,4-dinitrophenol (01 mM) or iodoacetate (1 miu) had slight or moderate effects on 45Ca2+ uptake. The data are most compatible with the presence in cerebral tissue of a sodium-calcium exchange process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb11969.x
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Carbon isotope fractionations in natural gases (1974)
    [s.l.] : Nature Publishing Group
    Nature 251 (1974), S. 134-135 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The results of isotope analyses of natural gases from Japan1, Taiwan2, Italy3 and the DDR4 are compared with isotope measurements of gases from the Federal Republic of Germany5 The German gases were taken from different geological formations and wells of the north-western German oil and gas ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/251134a0
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    Paper (German National Licenses)
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