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  • 1
    Electronic Resource
    Electronic Resource
    Insulin autoantibodies as determined by competitive radiobinding assay are positively correlated with impaired beta-cell function — The Ulm-Frankfurt population study (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 736-741 
    Details
    ISSN: 1432-1440
    Keywords: CIAA ; CF-ICA ; Beta-cell function ; IVGTT ; HLA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Out of a random population of 4208 non-diabetic pupils without a family history of Type I diabetes 44 (1.05%) individuals had islet cell antibody (ICA) levels greater or equal to 5 Juvenile Diabetes Foundation (JDF) units. 39 of these ICA-positives could be repeatedly tested for circulating insulin autoantibodies (CIAA) using a competitive radiobinding assay. The results were compared with the insulin responses in the intravenous glucose tolerance tests (IVGTT) and with HLA types. Six pupils were positive for CIAA. All of them had complement-fixing ICA, and 5 of them were HLA-DR4 positive. Three of the 6 showed a first-phase insulin response below the first percentile of normal controls. Our data indicate that in population-based studies CIAA can be considered as a high risk marker for impaired beta-cell function in non-diabetic ICA-positive individuals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01797611
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  • 2
    Electronic Resource
    Electronic Resource
    Single-compartment model analysis of thyrotropin-releasing hormone kinetics in hyper- and hypothyroid patients (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 1013-1019 
    Details
    ISSN: 1432-1440
    Keywords: Thyrotropin-releasing hormone ; RIA-TRH ; Pharmacokinetics ; Hypothyroidism ; Hyperthyroidism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pharmacokinetics of thyrotropin-releasing hormone (TRH) were assessed following an i.v. injection in blood of ten hyperthyroid, ten hypothyroid, and six normal subjects. A single-compartment model was employed. After methanol extraction, TRH concentrations were analyzed using a specific radioimmunoassay technique combined with fast protein liquid chromatography (FPLC). As for the basal levels of TRH, no differences were observed in either study group. Peak concentrations were always present two min after the injection of TRH. In the euthyroid subjects, TRH blood levels had a half-life (t 1/2) of 6.5±0.41 min, mean±SD, whilet 1/2 was 7.2±0.62 min in the hyperthyroid andt 1/2 was 12±1.67 min (p〈0.001) in the hypothyroid patients. The metabolic clearance rate (MCR) (82.2±15.3 liters/m2/day vs. 89.8±17.2) and the volume of distribution (Vd) (7.1±4.2 liters vs. 7.3±3.4) were approximately the same in the normal subjects and in the hyperthyroid group. MCR (66.2±15.3 Iiters/m2/day) and Vd (6.2±3.3 liters) were found to be lower in the hypothyroid patients. In FPLC, when TRH was added to plasma, it eluted in one peak. Blood samples taken 5 min after TRH i.v. injection had an elution profile of 9.94 ml. These data indicate that 1) TRH has a very short half-life, 2) hypothyroidism can prolong thet 1/2 of exogenous TRH, and 3) when TRH should be used in clinical studies, the function of the thyroid gland has to be taken into consideration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01646547
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  • 3
    Electronic Resource
    Electronic Resource
    Sex hormone concentrations in men with angiographically assessed coronary artery disease — Relationship to obesity and body fat distribution (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 664-668 
    Details
    ISSN: 1432-1440
    Keywords: Coronary artery disease ; Sex hormones ; Obesity ; Body fat distribution ; Angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The relationship between circulating sex hormone levels and the occurrence of coronary artery disease (CAD) was studied in a group of 274 men undergoing coronary angiography. Hormone levels in men with CAD (n=200) were compared to those in men found to be free of coronary lesions (n=74). No significant differences were found for serum concentrations of estradiol, total testosterone, sex-hormone-binding globulin, free androgen index, dehydroepiandrosterone sulfate, or cortisol between the two groups. Serum androgens were negatively correlated to age in both groups, whereas estradiol was weakly associated with total cholesterol in the group of men without CAD. No consistent associations were detected between sex hormone levels and the degree of obesity or the distribution of body fat, the latter being assessed by the ratio of waist-to-hip circumferences. The results of this study do not support a significant role of sex steroid hormones in coronary artery disease in men.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01649428
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  • 4
    Electronic Resource
    Electronic Resource
    The influence of l-(5-oxohexyl-)3.7-dimethylxanthine (BL 191) on the endocrine and exocrine pancreatic function in man during and following secretin and cholecystokinin-pancreozymin stimulation (1973)
    Springer
    Research in experimental medicine 161 (1973), S. 327-334 
    Details
    ISSN: 1433-8580
    Keywords: Methylxanthines ; Phosphodiesterase ; Cyclic AMP ; Intestinal hormones ; Endocrine pancreas ; Exocrine pancreatic function ; Adrenergic alpha-receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The intravenous administration of secretin or cholecystokinin-pancreozymin alone led to a short rapid rise in radio-immunologically measurable insulin, and to a stimulation of the hydrokinetic as well as the ecbolic, exocrine pancreatic function. During the administration of 1-(5-oxohexyl-)-3.7-dimethylxanthine (BL 191) no significant change in the endocrine and exocrine pancreatic secretion was registered, compared to the secretin injection alone, whereas BL 191 was able to inhibit the insulin and enzyme secretion after the administration of cholecystokinin-pancreozymin. The influence neither of secretin nor cholecystokinin-pancreozymin on the endocrine as well as the exocrine pancreas seems to be mediated directly by cyclic 3′-5′ adenosine monophosphate (cAMP), and the decrease of endocrine and exocrine pancreatic secretion, induced by cholecystokinin-pancreozymin during administration of BL 191, is probably due to an inhibition of the alpha-receptor system. Additional experiments are required for further elucidation of these conclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851457
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  • 5
    Electronic Resource
    Electronic Resource
    Der Einfluß von Atropin auf die durch intestinale Hormone induzierte Insulinsekretion des Menschen (1973)
    Springer
    Research in experimental medicine 160 (1973), S. 234-247 
    Details
    ISSN: 1433-8580
    Keywords: Insulin ; Intestinal hormones ; Atropine ; Vagus ; Insulin ; Intestinale Hormone ; Atropin ; Vagus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung und Schluβfolgerung Bei 35 stoffwechselgesunden freiwilligen Probanden wurde vor sowie nach Atropingabe die Wirkung der intestinalen Hormone Sekretin und Cholecystokinin-Pankreozymin (CCK-PZ) auf die endokrine und exokrine Pankreasfunktion untersucht. Außerdem wurde die Wirkung von intravenös und oral bzw. intraduodenal verabreichter Glucose und Aminosäuren auf die Insulinsekretion, den Blutzucker und die freien Fettsäuren ebenfalls vor und nach Atropinmedikation geprüft. Intravenös verabreichtes Sekretin konnte weder in seiner exokrinen noch endokrinen Pankreasfunktion durch Atropin beeinflußt werden. Intravenös injiziertes CCK-PZ konnte mittels Atropin sowohl in seiner ekbolischen wie auch endokrinen Pankreasfunktion gehemmt werden. Die Wirkung von CCK-PZ ist somit an ein cholinerges System gebunden, so daß es erlaubt erscheint, bezüglich der Pankreozyminwirkung von einem synergistisch bzw. additiv wirksam werdenden „neurohormonalen“ Mechanismus zu sprechen. Die durch parenteral verabreichte Glucose oder Aminosäuren induzierte Insulinsekretion wurde durch Atropin nicht beeinflußt; hingegen hemmte Atropin dieβ-cytotrope Wirkung von oral bzw. intraduodenal verabreichter Glucose oder Aminosäuren. Dies läßt auf eine Abhängigkeit von einem cholinergen oder parasympathischen System in der Freisetzung dieser intestinalen Hormone schließen.
    Notes: Summary and Conclusions In 35 metabolically normal subjects the effect of i.v. secretin and cholecystokinin-pancreozymin (CCK/PZ) on the endocrine and exocrine pancreatic function was investigated, before and after atropine. In addition, the effect of oral, intravenous and intraduodenal administration of glucose and amino acids on blood sugar and free fatty acids before and after the injection of atropine was studied. The secretin stimulated endocrine and exocrine pancreas was not affected by atropine. However, atropine inhibited the ecbolic and endocrine pancreatic function after stimulation with CCK/PZ. Therefore, the effect of i.v. CCK/PZ seems to be mediated by the cholinergic system, or even a “neuro-hormonal” system which acts synergically or additively. No influence of atropine on the insulin secretion induced by i.v. glucose or amino acids was observed. On the other hand, atropine inhibited the beta-cytotropic effect of glucose and amino acids after oral or intraduodenal administration. These findings indicate that the release of these intestinal hormones is dependent on the cholinergic or parasympathetic system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856787
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  • 6
    Electronic Resource
    Electronic Resource
    No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7–19 years (1991)
    Springer
    Diabetologia 34 (1991), S. 835-838 
    Details
    ISSN: 1432-0428
    Keywords: Viral antibodies ; Beta-cell function ; population study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7–19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for islet cell antibodies. Anti-coxsackie B1-5 IgM responses were detected in 14 of 44 (32%) of the islet cell antibody-positive subjects and in 7 of 44 (16%) control subjects. This difference did not reach the level of statistical significance. None of the islet cell antibody-positive subjects had specific IgM antibodies to mumps, rubella, or cytomegalovirus. There was also no increase in the prevalence or the mean titres of anti-mumps-IgG or IgA and anti-cytomegalovirus-IgG in islet cell antibody-positive subjects compared to control subjects. These results do not suggest any association between islet cell antibodies, and possibly insulitis, with recent mumps, rubella or cytomegalo virus infection. Further studies are required to clarify the relationship between islet cell antibodies and coxsackie B virus infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408360
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  • 7
    Electronic Resource
    Electronic Resource
    On line continuous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis (1992)
    Springer
    Diabetologia 35 (1992), S. 1087-1092 
    Details
    ISSN: 1432-0428
    Keywords: Continuous glucose sensing ; enzyme electrode ; glucose oxidase ; subcutaneous glucose concentration ; microdialysis ; oral glucose load
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For the normalisation of blood glucose levels in diabetic patients by feedback controlled insulin delivery, a self-manageable and reliable method for continuous glucose estimation is still not available. By combining a commercially available needle type dialysis probe (molecular cutoff 20,000 Da) with a sensitive glucose sensor, we obtained a device for continuous glucose measurement in dialysate. This device was tested in healthy volunteers during a 75-g oral glucose tolerance test and in Type 2 (non-insulin-dependent) diabetic patients. Venous glucose and subcutaneous sensor signal were followed for 300 min (ten healthy subjects), 21 h (three healthy subjects) or 9 h (seven Type 2 diabetic patients). The recovery of the microdialysis was interindividually different, but after calibration, glucose levels in the dialysate and subcutaneous glucose sensor signal correlated well (r = 0.84–0.95). Under the assumption of a physiologic and technical delay between intravenous and subcutaneous glucose, correlation coefficient between intravenous glucose and subcutaneous sensor signal ranged from 0.60 to 0.93. We conclude that changes in blood glucose could be monitored in the subcutaneous tissue by the microdialysis technique in a continuous on line manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02221686
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  • 8
    Electronic Resource
    Electronic Resource
    The role of the exocrine pancreas in the stimulation of insulin secretion by intestinal hormones (1971)
    Springer
    Diabetologia 7 (1971), S. 68-72 
    Details
    ISSN: 1432-0428
    Keywords: Glucose ; duct ligation ; IMI ; secretin ; pancreozymin ; K-value
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'influence de la sécrétine et de la pancréozymine intravenieuses sur la sécrétion d'insuline a été étudiée chez des rats ayant une insuffisance pancréatique exocrine. La sécrétine et la pancréozymine ont causé une sécrétion d'insuline significative chez des rats normaux. L'effet de ces hormones a été différent chez les animaux ayant une insuffisance pancréatique exocrine; alors que la pancréozymine causait une sécrétion d'insuline chez ces animaux, la sécrétine n'en causait aucune. Le glucose intravenieux, quant à lui, produisait une augmentation d'insuline du sang même chez les rats ayant une insuffisance pancréatique exocrine. Il semble que seule l'action de la sécrétine sur la sécrétion d'insuline soit liée au pancréas exocrine intact. Par contre la pancréozymine stimule la sécrétion d'insuline même dans le cas d'une insuffisance pancréatique exocrine. Ces résultats in vivo sont indentiques à ceux obtenus avec les ilôts isolés du pancréas des rats.
    Abstract: Zusammenfassung Bei Ratten mit exokriner Pankreasinsuffizienz, erzeugt durch vollständige Ligatur sämtlicher Pankreasausführungsgänge mit anschließender fettiger Degeneration, wurde der Einfluß von Sekretin und Pankreozymin i.v. auf das immunologisch meßbare Insulin geprüft. Bei normalen Ratten führten Sekretin und Pankreozymin zu einer signifikanten Insulinausschüttung. Bei Tieren mit Pankreasinsuffizienz war ein unterschiedlicher Effekt beider Hormone nachzuweisen. Während Pankreozymin auch bei pancreasinsuffizierten Tieren einen deutlichen Anstieg der Insulinsekretion bewirkt, fehlt nach Sekretin die reaktive Insulinsecretion. I.v. Glucose bewirkte hingegen auch bei den pankreasinsuffizienten Ratten einen Insulinanstieg in Plasma. Offensichtlich ist lediglich die insulinstimulierende Wirkung von Sekretin an ein intaktes exokrines Pankreas gebunden, während Pankreozymin auch bei Pankreasinsuffizienz das Inselsystem zur Insulinabgabe veranlaßt. Diese Befunde in vivo sind übereinstimmend mit den Versuchen an isolierten Inseln der Ratten.
    Notes: Summary A comparison was made of the effects of the intestinal hormones secretin and pancreozymin on insulin secretion in non-diabetic rats with experimentically induced exocrine pancreatic insufficiency and in control animals. The rats with exocrine pancreatic insufficiency exhibited normal disappearence of glucose and secretion of insulin. In rats with exocrine pancreatic insufficiency secretin did not lead to any increase in insulin secretion in contrast to its effect in the controls. In rats with exocrine pancreatic insufficiency pancreozymin evoked secretion of insulin to the same extent as in the normal animals. — From these results it is inferred that the effect of secretion upon the β-cells of the rat is dependent upon the presence of intact exocrine pancreatic tissue. However, pancreozymin and glucose exert their effects upon the β-cells directly without the involvement of the exocrine portion of the pancreas. All of these findings made under conditions in vivo are in perfect accord with studies made on isolated islets of rats subjected to the same stimuli in the preparation in vitro.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443883
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  • 9
    Electronic Resource
    Electronic Resource
    Hyperglucagonemia of the isolated perfused pancreas of diabetic mice (db/db) (1973)
    Springer
    Diabetologia 9 (1973), S. 400-402 
    Details
    ISSN: 1432-0428
    Keywords: Diabetic mice ; isolated perfused pancreas ; high insulin levels ; hyperglucagonemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Diabetes mellitus is held to be accompanied by inappropriately high levels of plasma glucagon relative to blood glucose concentrations. This has been interpreted as indicating lack of insulin. To establish glucagon release in presence of high levels of endogenous insulin, the effects of both glucose and arginine were studied in the isolated perfused pancreas of genetically diabetic mice (db/db). Stimulation with glucose 2.75 mM or glucose plus arginine 8.25 mM exhibited a pronounced hyperglucagonemia. Following glucose 8.25 mM, however, there was no depression of glucagon secretion. Despite excessive high levels of endogenous insulin, there was a pattern of rather non-suppressible glucagon release. Lack of insulin per se, therefore, is unlikely to be the sole cause of hyperglucagonemia in this type of genetic animal diabetes mellitus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01239436
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  • 10
    Electronic Resource
    Electronic Resource
    The effect of serotonin on in vitro insulin secretion and biosynthesis in mice (1974)
    Springer
    Diabetologia 10 (1974), S. 411-414 
    Details
    ISSN: 1432-0428
    Keywords: Insulin secretion ; insulin biosynthesis ; pancreatic monoamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of serotonin on insulin secretion and biosynthesis was studied using isolated islets of mice. Serotonin produced a small stimulatory effect on insulin secretion when glucose was present in the incubation medium at a low concentration. On the other hand, an inhibition of insulin secretion was obtained with serotonin when glucose in the medium reached 3.0 mg/ml concentration. No significant effect of serotonin was obtained on insulin biosynthesis, neither in the presence of low nor with a high glucose concentration. These results suggest that the effect of this monoamine on insulin secretion is not mediated via its effect on insulin biosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221630
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