Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1990-1994  (18)
  • 1965-1969  (1)
  • 1955-1959
  • Life and Medical Sciences  (13)
  • phase II  (3)
  • supercritical fluid chromatography  (3)
Source
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma (1992)
    Springer
    Investigational new drugs 10 (1992), S. 205-209 
    Details
    ISSN: 1573-0646
    Keywords: phase II ; fazarabine ; adenocarcinoma ; pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract We conducted a phase II evaluation of fazarabine 1.75–2.0 mg/m2hr over 72 hours every 28 days in 14 previously untreated patients with advanced adenocarcinoma of the pancreas. The intial dose was 1.75 mg/m2/hr in 10 patients, and 2.0 mg/m2hr in 4 patients. The dose was escalated in 8 patients, including all 4 who started at the higher dose level. Toxicity was unexpectedly mild. The median WBC nadir was 4.4 (range: 2.4–15.8)×103/μl, the median absolute neutrophil nadir was 3.2 (range: 0.9–13.0)×103/μl, and the median platelet count was 134.0 (range: 48.0–291.0)×103/μl. Gastrointestinal toxicity was generally mild. No major responses were seen, excluding, with 95% confidence, a response rate in excess of 20%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00877247
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma (1992)
    Springer
    Investigational new drugs 10 (1992), S. 313-316 
    Details
    ISSN: 1573-0646
    Keywords: phase II ; edatrexate ; adenocarcinoma ; pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract We conducted a phase II evaluation of edatrexate in 17 previously untreated patients with advanced adenocarcinoma of the pancreas; 14 patients had at least one month of therapy. The initial dose was 80 mg/m2iv. Treatment was administered weekly for 5 weeks, then every other week. Toxicity was generally mild. The median WBC nadir was 5.4 (range 0.6–7.4)×103/μl, and the median platelet nadir was 164.0 (range 62.0–341.0)×103/μl. One patient died with sepsis and gastrointestinal bleeding associated with pancytopenia. Five patients had a mild rash. Nausea occurred in 6 patients, including 3 who had vomiting. In addition, 11 patients complained of vague malaise which seemed to begin within 24–48 hours after administration of edatrexate, and lasted for 2 to 3 days, resolving within 6 days of drug administration. Median survival was 85 days. Although 5 patients had stable disease, including one with relief of pain, no major responses were seen, excluding, with 95% confidence, a response rate in excess of 20%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00944187
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Phase II trial of gemcitabine (2,2′-difiuorodeoxycytidine) in patients with adenocarcinoma of the pancreas (1994)
    Springer
    Investigational new drugs 12 (1994), S. 29-34 
    Details
    ISSN: 1573-0646
    Keywords: pancreas ; adenocarcinoma ; gemcitabine ; 2,2′-difluorodeoxycytidme ; phase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Gemcitabine is a novel nucleoside analog which demonstrated a broad spectrum of preclinical acitivity in solid tumor models, and responses in patients with pancreas cancer during phase I evaluation. Patients with measurable adenocarcinoma of the pancreas who had received no previous chemotherapy were eligible for this multicenter phase II clinical trial. Gemcitabine 800 mg/m2 was administered intravenously weekly for 3 consecutive weeks, followed by one week rest, every 4 weeks. Forty-four patients entered the trial; 35 had at least 2 cycles of therapy. Partial response was observed in 5 patients (11%, estimated 95% confidence interval 2–20%), with a median duration of 13 months. All responding patients had stabilization or improvement in performance status. Fourteen patients had stable disease of 4 or more months. The median WBC nadir was 3.8 × 103/μl (range 1.6–9.3) and the median absolute neutrophil (ANC) nadir was 2.0 × 103/μl (range 0.4–7.2). Thrombocytopenia - 100.0 × 103/μl was observed in 15 patients; the median platelet nadir was 123.0 (range 30.0–245.0). All patients experienced a mild to moderate flu-like syndrome. In addition, one patient had a mild hemolytic-uremic syndrome which appeared related to gemcitabine therapy. Gemcitabine demonstrated marginal activity in this resistant neoplasm, without excessive toxicity. Further evaluation, including the use of more intense dosing and/or combination therapy, is warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873232
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    A multiplanar anatomic study of the cervical proximal nerve roots and spinal nerves (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    Clinical Anatomy 5 (1992), S. 433-440 
    Details
    ISSN: 0897-3806
    Keywords: anatomy ; spine ; sheath ; Life and Medical Sciences ; Miscellaneous Medical
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: An anatomic study focused on the proximal cervical spinal nerves has not been reported. Therefore, we dissected the cervical spinal nerves of three cadavers and examined stained sections in parasagittal and axial planes through the proximal cervical spinal nerves and root sheaths. These studies documented distinct segments of the spinal nerve which had not been completely described in the previous anatomic studies. The sheath originates from the dural sac as a common sleeve, divides into two sleeves, one containing the ventral root and one the dorsal root, and then distal to the dorsal root ganglion fuses again into one sleeve. A space, the interradicular cleft, separates the dorsal and ventral portions of the sleeve. The proximal segment of the spinal nerve proper distal to the dorsal root ganglion is composed of multiple small fascicles surrounded by a dense epineurium. The presence of an interradicular cleft in the cervical nerve root sheath and of fascicles in the cervical spinal nerve has significance for imaging of the cervical spinal nerves and for the pathogenesis of symptoms in cases of partial compression. © 1992 Wiley-Liss, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ca.980050603
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Dihydropyridine calcium antagonist modulates cholesterol metabolism and eicosanoid biosynthesis in vascular cells (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 48 (1992), S. 393-400 
    Details
    ISSN: 0730-2312
    Keywords: calcium channel blocker ; atherosclerosis ; LDL ; LDL-receptor ; vascular smooth muscle ; PGI2 ; cyclic AMP ; cyclooxygenase ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Recent clinical studies have shown that calcium channel blockers can retard and possibly reduce the angiographic progression of coronary artery disease. Calcium channel blockers also inhibit dietary-induced atherosclerosis in animal models of this disease. In this study, we delineate potential cellular and molecular mechanisms by which nicardipine, a dihydropyridine calcium antagonist, may alter lipoprotein and cholesterol trafficking, affect the regulatory signal transduction pathways involved in accelerating cholesteryl ester (CE) catabolism in vascular smooth muscle cells, and modulate cell-cell interactions of vascular and inflammatory cells. We demonstrate in arterial smooth muscle cells that nicardipine increases (1) LDL binding, uptake, and degradation, (2) RNA transcript levels for the LDL receptor, (3) CE catabolic activity, (4) PGI2 release, and (5) RNA transcript levels for cyclooxygenase. Furthermore, nicardipine blocked cytokine-induced monocyte adhesion to endothelial cells and smooth muscle cells. Taken together, these findings support the hypothesis that nicardipine may function as an anti-atherosclerotic agent by promoting CE catabolism and cholesterol clearance and by reducing monocyte adhesion to the activated endothelium.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240480408
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    The fine structural localization and selective inhibition of nucleosidephosphatases in the rat adrenal cortexThis work was supported in part by grants from the National Cancer Institute (5T1-CA-5055) and the National Institute of Arthritis and Metabolic Diseases (A-3688), National Institutes of Health, Department of Health, Education and Welfare. (1965)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 152 (1965), S. 265-277 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Fine structural localization of enzymes hydrolyzing nucleoside phosphates in the rat adrenal cortex has been determined, and the selective inhibition of those enzymes exhibiting intracellular localization has been effected. Glutaraldehyde-fixed adrenocortical tissue was incubated in a medium which contained a nucleoside mono-, di- or triphosphate of adenosine, inosine, guanosine, or cytidine as substrate. Intracellular enzymatic activity was exhibited when one of three nucleoside phosphate substrates was employed. When IDP was used, final product of enzymatic activity was found on membranes of the endoplasmic reticulum, Golgi cisternae and intramitochondrial microvesicles. Final product was localized on the membranes of the endoplasmic reticulum and certain mitochondria when ITP was used. With GTP as substrate, activity was primarily localized on mitochondrial microvesicles and agranular endoplasmic reticulum, with no Golgi involvement noted.The phosphatases for which intracellular localization was determined exhibited four different sites of activity: (a) agranular endoplasmic reticulum, (b) microvesicles within mitochondria, (c) nuclear membrane, and (d) subendothelial and/or intercellular spaces with occasional involvement of the plasma membrane. When nicotinamide was added to the incubation media, intracellular phosphatase activity was inhibited. Extracellular enzymatic activity was unaffected by nicotinamide. The possible mode of action of nicotinamide in enhancing steroidogenesis and inhibiting intracellular phosphatase activity is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091520306
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The p53 protein detected by immunohistochemical staining is not always mutant (1993)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 53 (1993), S. 248-248 
    Details
    ISSN: 0730-2312
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: In human mammary carcinoma, positive immunohistochemical staining for p53 protein is not always indicative of mutation in the p53 gene. Although positive staining is seen in excess of 50% of tumours, mutations have been found in only some 20% of cases. In this presentation, positive p53 staining in mammary carcinomas will be related to the presence and absence of mutation and other possible underlying mechanisms.In some positively stained tumours a mutation has been found. In others, no mutation has been demonstrated and apart from possible stabilisation by a protein such as MDM2, there are alternative underlying mechanisms for this discrepancy. Wild type p53 is elevated in response to DNA damage. This effect can be seen in patients given pre-operative chemotherapy and in cell lines irradiated with UV light and with x-rays. Strong positive staining in scattered nuclei has been found in cell lines with activated ras and myc genes. We postulate that this may also be the reason for similar patterns observed in human tumours.Comparable mechanisms may be active in inherited cancers. Although positive p53 staining in some Li-Fraumeni syndrome patients is associated with mutation, in other Li-Fraumeni-like families, no mutation has been found despite positive staining in tumour and normal tissues.Whatever the mechanism underlying the stabilisation of the protein, increased expression of p53 protein in the majority of tumour cells appears to be associated with poor prognosis in breast carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240531147
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Investigation of retention and selectivity in high-temperature, high-pressure, open-tubular supercritical fluid chromatography with CO2 mobile phase (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 5 (1993), S. 441-449 
    Details
    ISSN: 1040-7685
    Keywords: open-tubular columns ; supercritical fluid chromatography ; retention ; selectivity ; pressure ; temperature ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We studied solute retention for n-hydrocarbons, (low-molecular-weight) polystyrenes, an ethoxylated surfactant, and a selectivity test mix on open-tubular columns with methyl-, biphenyl-, and cyanopropyl-substituted stationary phases for pressures up to 680 atm and temperatures up to 240°C. The solute elution range varied tremendously with column choice, with the least retentive stationary phases providing the highest elution range. However, the best resolution and largest analysis range were obtained with the most retentive stationary phase and the highest pressures. Increasing the temperatures above 160°C did not cause a large increase in elution pressure for the solutes used in this study. Exceptionally large shifts in selectivity with temperatures up to about 160°C occurred for the biphenyl and cyanopropyl stationary phases. The availability of pressures higher than 680 atm, coupled with adequately retentive stationary phases used at optimal temperatures, would further increase the analysis scope of opentubular supercritical fluid chromatography.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mcs.1220050508
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Dynamic film formation and the use of retention gaps with direct injection in open-tubular supercritical fluid chromatography (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Microcolumn Separations 5 (1993), S. 261-273 
    Details
    ISSN: 1040-7685
    Keywords: open-tubular columns ; supercritical fluid chromatography ; direct injection ; phase behavior ; critical mixture curves ; retention gap ; solvent effect ; phase-ratio focusing ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Open-tubular supercritical fluid chromatography (SFC) is a useful technique for many analyses, but is somewhat limited, in current practice, with respect to trace analysis of liquid samples. Direct injection of the volumes required for trace analysis with ordinary detectors creates a meter or more length of flooded zone and may lead to unacceptable band broadening. We studied solvent mass transfer on short, uncoated columns for several solvents forming Type I binary mixtures with CO2, and found evidence in the solvent peak shapes of distinct liquid and vapor phases, with the liquid present as a dynamically formed film. This study suggests that selecting an injection temperature and pressure to reduce, but not eliminate, the surface tension of the liquidvapor interface, and increasing the mobile phase velocity during injection increase the liquid film thickness and reduce the length of the resulting flooded zone. When a separate uncoated inlet tube (that is, a retention gap) is used to connect the injector with the column, decreasing the inlet tube radius improves the ratio of maximum effective injection volume to inlet tube volume.Just as in GC, dynamically formed films function as pseudo-stationary phases during injection. Without a liquid film, solutes can be transported by injection-solvent-modified mobile phase well beyond the length of a typical film, increasing the difficulty of refocusing the solutes before separation. Refocusing solutes from film-coated flooded zones is easily accomplished using either a solvent effect (specifically, solvent trapping) or phase-ratio focusing.We recommend the use of solvents with phase behavior like toluene and carbon tetrachloride, both of which form films at convenient temperatures and pressures. We discourage the use of solvents with phase behavior like n-pentane which tend to make single-phase, supercritical mixtures with CO2 under typical SFC injection conditions.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mcs.1220050311
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Temporally and spatially restricted expression of apolipoprotein J in the developing heart defines discrete stages of valve morphogenesis (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Developmental Dynamics 201 (1994), S. 290-296 
    Details
    ISSN: 1058-8388
    Keywords: ApoJ/clusterin ; Heart ; Cardiac development ; Cardiac valves ; Endocardial cushions ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: During cardiac valve morphogenesis, a series of interactions between the mesodermal-derived myocardium and the overlying endothelium lead to condensed leaflet structure formation. At the atrioventricular (AV) canal, endocardial cells are transformed by specialized underlying myocardial cells into endocardial cushions, and then remodeled into mitral and tricuspid valves. Aortic and pulmonary valves develop by a similar mechanism in the primitive outflow tract. Few genes exhibit restricted spatiotemporal expression in these critical embryonic structures, thus limiting the clues to the sequence of molecular events necessary for valvulogenesis. Apolipoprotein J (ApoJ), a secreted glycoprotein expressed in a variety of cell types at tissue interfaces, exhibits a highly restricted and dynamic expression pattern in the developing heart. ApoJ transcripts were detected in mice at day 9.0 of gestation in the wall of the developing truncus arteriosus. By day 10, intense signal occurred in a thin layer of myocardial cells adjacent to developing endocardial cushions of both atrioventricular canal and truncus arteriosus. No apoJ mRNA was present in the overlying endocardial cushions until day 13.5 when prevalvular condensation begins. Intense expression occurred in the stromal connective tissue throughout leaflet formation. The highly restricted spatiotemporal expression pattern of apoJ in the developing heart implicates its role in the morphogenesis of the AV canal and outflow tract into cardiac valves. © 1994 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1002010311
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...