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  • 1990-1994  (2)
  • 1965-1969  (2)
  • Industrial Chemistry  (2)
  • Aedes albopictus  (1)
  • Ethanol
  • 1
    Electronic Resource
    Electronic Resource
    Tolerance to ethanol's effects on operant performance in rats: role of number and pattern of intoxicated practice opportunities (1992)
    Springer
    Psychopharmacology 109 (1992), S. 112-120 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Operant performance ; Tolerance ; Intoxicated practice ; Compensatory behaviors ; Acute ethanol withdrawal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acquisition and retention of tolerance to ethanol's rate-decreasing effects on operant performance were examined in rats which received a 52-day regimen of ethanol or saline injections prior to and/or after each daily session. Eight groups of rats differed on: (a) number of days with intoxicated practice (pre-session ethanol); (b) intermittent (spaced) or daily (massed) intoxicated practice; and (c) post-session ethanol or saline on nonintoxicated practice days. Massed practice groups were given their presession saline days prior to their pre-session ethanol days. Ethanol dose-effect tests were given prior to, during, and after the chronic injection regimen. Under both spaced and massed practice conditions, the magnitude of tolerance developed increased directly with the number of pre-session ethanol days, even when absolute ethanol exposure was constant. No group showed complete tolerance loss. The post-session ethanol supplements (a) facilitated tolerance development in spaced practice groups and tolerance loss in massed practice groups, (b) blocked ethanol's low dose rate-increasing effects, and (c) produced an acute withdrawal-like performance disruption the next day. The results suggest that both intoxicated practice and practice during acute ethanol withdrawal influence the acquisition and retention of compensatory behaviors during ethanol tolerance development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245488
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Steuerung und Regelung von chemischen Fabrikationsprozessen bei instationärem Betrieb (1966)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 38 (1966), S. 239-241 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Es werden Prinzipien, nach denen Regelungen und Steuerungen des instationären Betriebes allgemein möglich sind, aufgezählt und Vor- und Nachteile verschiedener Varianten miteinander verglichen.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330380310
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Steuerungen und Regelungen von Betriebsanlagen der pharmazeutischen Chemie (1965)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 37 (1965), S. 232-234 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Industrial Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Die Synthesen der pharmazeutischen Produkte umfassen meist zahlreiche Stufen, wobei Chargenprozesse mit kontinuierlichen Prozessen abwechseln. Daher müssen auch die kontinuierlich arbeitenden Apparaturen oft angehalten werden. Diese Besonderheit muß bei der Auswahl der Schaltelemente berücksichtigt werden.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330370310
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Genetic changes in methotrexate-resistant mosquito cells (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 15 (1990), S. 79-92 
    Details
    ISSN: 0739-4462
    Keywords: Aedes albopictus ; gene amplification ; dihydrofolate reductase ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: A stepwise selection procedure was used to obtain from Mtx-5011 Aedes albopictus cells, variants with increased resistance to methotrexate (mtx). On the basis of growth, the Mtx-5011 derivatives were 270- to 3,000-fold more resistant to mtx than wild-type mosquito cells. Properties associated with mtx resistance in these cells were consistent with amplification of the dihydrofolate reductase (DHFR) gene. The cells overproduced DHFR protein, were enriched with DHFR mRNA, and DNA from resistant cells was enriched for a band that likely contained the DHFR coding sequence. Karyotype analysis indicated that high levels of resistance were accompanied by a conversion to tetraploidy, chromosome rearrangements, and an apparent duplication of one of the mosquito chromosomes.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940150203
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    Paper (German National Licenses)
    Fulltext
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