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  • 1990-1994  (4)
  • 1965-1969
  • Haemolytic uraemic syndrome  (2)
  • Muscle  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Prostacyclin in diarrhoea-associated haemolytic uraemic syndrome (1993)
    Springer
    Pediatric nephrology 7 (1993), S. 515-519 
    Details
    ISSN: 1432-198X
    Keywords: Haemolytic uraemic syndrome ; Prostacyclin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of prostacyclin (PGI2) in the pathogenesis of haemolytic uraemic syndrome (HUS) is controversial. In part, confusion has been caused by failure to distinguish between two main sub-types of the syndrome: extrinsic, diarrhoea-associated HUS (D+ HUS), usually caused by infection with verocytotoxin-producingEscherichia coli orShigella dysenteriae, and the heterogeneous group of non-prodromal forms where intrinsic factors predominate (D− HUS). This paper critically reviews data confined to D+ HUS. Two methods have been used to assess PGI2 synthesis; the generation of PGI2 from endothelium in the presence of HUS plasma in vitro and the measurement of stable metabolites in body fluids. No concensus could be reached with regard to the former. The reported increase of PGI2 stable metabolites in plasma may represent reduced clearance or increased carriage by plasma lipids. Apparent differences between studies of urinary excretion of PGI2 metabolites may reflect the way excretion was expressed. If the metabolite concentration is factored for urinary creatinine, it appears that renal excretion and thus renal synthesis of PGI2 is reduced. However, these are insufficient data on which to attribute the pathogenesis of D+ HUS to disordered PGI2 metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00852530
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The expression of blood group P1 in post-enteropathic haemolytic uraemic syndrome (1990)
    Springer
    Pediatric nephrology 4 (1990), S. 59-61 
    Details
    ISSN: 1432-198X
    Keywords: Blood group P1 ; Haemolytic uraemic syndrome ; Verotoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood group P1 expression was scored by direct agglutination in 32 patients who had previously developed post-enteropathic haemolytic uraemic syndrome (HUS). Sixty-six children of similar ages undergoing venepuncture for other renal disorders acted as controls. The expression of P1 in controls was that expected from the normal caucasian population, 23% being negative. By contrast, there was an excess of HUS patients with weak or absent expression of P1 (χ2 for linear trend 5.45,P〈0.02), and this was particularly evident in those with a poor outcome. Verotoxin (VT), which is associated with HUS, requires the terminal disaccharide of the P1 antigen to bind to cells, and after internalization disrupts the transcription of ribonucleic acid. Mature erythrocytes do not synthesize protein and may be toxin resistant. We postulate that strong expression of P1 antigen may promote the binding of VT to red cells and thus reduce the dose to vulnerable nucleated cleated endothelial cells. P1 positivity may be protective, and P1 negativity a risk factor in HUS.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00858441
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Estimating transit time for capillary blood in selected muscles of exercising animals (1992)
    Springer
    Pflügers Archiv 421 (1992), S. 578-584 
    Details
    ISSN: 1432-2013
    Keywords: Muscle ; Morphometry ; Blood flow ; Microcirculation ; Oxidative capacity ; Oxygen transport ; V2,max
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mean minimal capillary transit time was estimated in muscles of various animals using a combination of physiological and morphometric methods. Radioactive microspheres were injected intravascularly in various animals running on a treadmill at maximum oxygen consumption rate (VO2,max) to label blood flow to individual muscles. The muscles were then removed and preserved by standard methods for electron microscopy. The volume density of mitochondria was measured to assess muscle oxidative capacity. Capillary densities in muscle cross-sections, capillary diameters and tortuosities were incorporated into an estimate of capillary volume per unit muscle mass. Mean capillary transit time (t c) in the exercising muscles was estimated by dividing mass-specific capillary volume by mass-specific blood flow. Estimates of t c ranged from values near 1 s in horse heart and thigh muscles to 0.2 s in duck gastrocnemius. The relationship between muscle blood flow and t c was hyperbolic. The experimental data indicate a limiting value of 0.2 s for transit times at very high blood flows. There was no correlation between t c and body-mass-specific VO2,max.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00375054
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Evidence of fibre hyperplasia in human skeletal muscles from healthy young men? (1991)
    Springer
    European journal of applied physiology 62 (1991), S. 301-304 
    Details
    ISSN: 1439-6327
    Keywords: Muscle ; Muscle fibres ; Histocytochemistry ; Hyperplasia ; Handedness
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cross-sections (thickness 10 μm) of whole autopsied left and right anterior tibialis muscles of seven young previously healthy right-handed men (mean age 23 years, range 18–32 years) were prepared for light-microscope enzyme histochemistry. Muscle cross-sectional area and total number of fibres, mean fibre size (indirectly determined) and proportion of the different fibre types (type 1 and type 2 on basis of myofibrillar adenosine triphosphatase characteristics), in each muscle cross-section were determined. The analysis showed that the cross-sectional area of the left muscle was significantly larger (P〈0.05), and the total number of fibres was significantly higher (P〈0.05), than for the corresponding right muscle. There was no significant difference for the mean fibre size or the proportion of the two fibre types. The results imply that long-term asymmetrical low-level daily demands on muscles of the left and the right lower leg in right-handed individuals provide enough stimuli to induce an enlargement of the muscles on the left side, and that this enlargement is due to an increase in the number of muscle fibres (fibre hyperplasia). Calculations based on the data also explain why the underlying process of hyperplasia is difficult, or even impossible, to detect in standard muscle biopsies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634963
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    Paper (German National Licenses)
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