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  • 1990-1994  (3)
  • 1960-1964  (7)
  • Chemistry  (7)
  • Rheumatoid arthritis  (3)
  • Competitive RT-PCR
  • Molecular markers
  • 1
    Electronic Resource
    Electronic Resource
    The neo-synovial membrane of patients with active rheumatoid arthritis at resynovectomy (1990)
    Springer
    Rheumatology international 10 (1990), S. 191-198 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Synovitis ; Synovial membrane ; Neo-synovial membrane ; Resynovectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neo-synovial membranes, which formed after “primary” synovectomy in 21 patients with rheumatoid arthritis (RA), were studied at resynovectomy. The clinical, histomorphological, and immunohistological data were compared with data derived from “primary” synovial membranes from RA and osteoarthritis (OA) patients. The clinical data suggest a less active rheumatoid inflammatory response after synovectomy. Histomorphologicaly, the synovitis in resynovectomized neosynovial membranes of RA revealed no qualitative differences when compared with synovitis in the “primary” synovium. However, the degree of the inflammatory rection evaluated by the different parameters was found to be distinctly lower. The immunohistological data correlated with these findings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274832
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  • 2
    Electronic Resource
    Electronic Resource
    Two-dimensional electrophoresis of synovial tissue, synovial fluid and serum in patients with rheumatoid arthritis and related diseases (1990)
    Springer
    Rheumatology international 10 (1990), S. 177-183 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; Immunoglobulins ; Protein pattern ; Two-dimensional electrophoresis ; Synovial membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the technique of two-dimensional (2D) electrophoresis with consecutive silver staining, we investigated samples of serum, synovial fluid and synovial tissue obtained from 19 patients suffering from rheumatoid arthritis (RA) or non-RA arthritis. From these experiments we have drawn the following conclusions. 2D electrophoresis of serum, synovial fluid and synovial tissue extracts taken from patients suffering from joint diseases is a reproducible method. Repeated runs of the same sample reveal an essentially constant protein spot pattern. The time period between surgery and tissue preparation did not influence the number of protein spots when less than 15 h was involved. The protein spot number is always lower in synovial fluid than in either synovial tissue or serum in RA and non-RA patients. The mean value for the number of spots is 68 for the inflamed tissue irrespective of the cause of arthritis (RA and non-RA group taken together) and 47 for the control group. This difference is significant. We were able to definitely identify 7 spots in the tissue extract. We did not find RA-specific protein spots in either serum, synovial fluid or tissue extracts from the synovial membrane. The only significant difference between RA patients and either non-RA or control group patients concerning the protein spot pattern is the increased size of the immunoglobulin spot (mainly IgG) in RA. In addition, we discuss possible reasons for failure of the 2D electrophoresis technique to detect disease-specific protein patterns.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02274830
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Persistence of B19 parvovirus in synovial membranes of patients with rheumatoid arthritis (1992)
    Springer
    Rheumatology international 12 (1992), S. 147-151 
    Details
    ISSN: 1437-160X
    Keywords: Rheumatoid arthritis ; B19 parvovirus ; Polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent clinical observations support the hypothesis that persistent parvovirus B19 is a triggering factor of rheumatoid arthritis (RA) in certain genetically predisposed individuals. If this hypothesis is correct, a number of RA patients may exhibit parvovirus B19 DNA in their synovial membranes. We tested the synovial tissue and peripheral blood leukocytes of 20 patients with RA, 24 patients with other arthritides or osteoarthritis (non-RA), and 34 healthy blood donors for the presence of parvovirus B19 DNA using specific DNA amplification by polymerase chain reaction (PCR). Using this technique, parvovirus B19 DNA was demonstrated in the synovial biopsies of 75% of patients with RA but in those of only 16.7% of patients with non-RA. In autologous peripheral blood mononuclear cells the percentage of PCR-positive patients was about 15% in both RA and non-RA groups and did not differ from that in healthy controls. When the PCR data were correlated with the presence of anti-parvovirus B19 IgG antibodies in serum and synovia all patients with parvovirus B19 DNA in peripheral blood alone or in both peripheral blood and synovial membrane were seropositive. In contrast, about 40% of patients with parvovirus B19 DNA restricted to the synovial membrane were seronegative. These data indicate a highly disease-related persistence of parvovirus B19 in the rheumatoid synovium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00274934
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  • 4
    Electronic Resource
    Electronic Resource
    Neue Dibor-Verbindungen (1961)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 73 (1961), S. 408-408 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19610731112
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    1.3.4-Triaza-2.5-diborolidine (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 76 (1964), S. 535-535 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19640761207
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  • 6
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie dea Bors. XX Zur Kenntnis von Alkyl-bis(dimethylamino)-boranen (1963)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 322 (1963), S. 297-309 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Alkyl-bis(dimethylamino) boranes can be obtained by solvolysis of alkyl boron dichlorides in dimethyl amine, or by alkylation of bis(dimethylamino)-chloro-borane with alkyl lithium. Their reactions with HCl, HBr and HJ was studied.
    Notes: Alkyl-bis(dimethylamino)((dimethylamino))borane erhält man bei der Dimethylaminolyse von Alkylbordichloriden oder bei der Alkylierung von Bis(dimethylamino)-chloroboran mit Alkyl-Lithium. Ihr Verhalten gegenüber den Halogenwasserstoffen HCl, HBr und HJ wurde untersucht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19633220509
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  • 7
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie des Bors. XVI. Dialkylamino-chloro-borane (1962)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 318 (1962), S. 293-303 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Bis(dialkylamino) boranes, (R2N)2BH, are easily prepared either by hydrogenation of the corresponding chlorides, (R2N)2BCl, by means of LiH or by transamination of [(CH3)2N]2BH. From the reaction products and two moles of HCl, dialkylammonium chlorides and the easily dimerizing dialkylamino chloroboranes, R2NB(H)Cl, are obtained. These react, in the monomeric form, with further HCl to R2NH · B(H)Cl2. In contrast with the other bis(dialkylamino)-boranes, [(CH3)2N]2BH reacts with HCl without any cleavage of the B-N bond yielding the salt [Cl(H)B(NHMe2)2]Cl.
    Notes: Bis(dialkylamino)-borane, (R2N)2BH, sind durch Hydrierung von Bis(dialkylamino)chloroboranen mit Lithiumhydrid in Äther und durch Umaminierung von Bis(dimethylamino)-boran leicht zugänglich. Bei der Umsetzung der Bis(dialkylamino)-borane mit 2 Mol HCl erhält man Dialkylaminhydrochloride und Dialkylamino-chloro-borane, R2NB(H)Cl, die sich leicht dimerisieren. An die monomeren Verbindungen lagert sich HCl zu R2NH · B(H)Cl2 an. Im Gegensatz zu den anderen Bis(dialkylamino)-boranen reagiert (Me2N)2BH mit HCl ohne Spaltung der B-N-Bindung zu dem Salz [Cl(H)B · (NHMe2)2]Cl.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19623180508
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  • 8
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie des Bors. XXI. Zur Kenntnis der Symmetrischen Dialkyl-dibor-bis-dimethylamide (1963)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 324 (1963), S. 129-145 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Symmetrical dialkyl-bis(dimethylamino)-diborons, R(Me2N)B-B(NMe2)R, are obtained by dehalogenation of RB(NMe2)Cl with sodium-potassium alloy. The B-B bond in these compounds is more stable than that in B2(NMe2)4. Nucleophilic and electrophilic substitutions are generally accompanied by extensive disproportionation of the diboron compounds.
    Notes: Durch Dehalogenierung von RB(NMe2)Cl2) mit Natrium-Kaliumlegierung erhält man thermisch relativ stabile Dialkyl-dibor-bis(dimethylamide), R(Me2N)B-B(NMe2)R. Die B-B-Bindung ist in diesen Verbindungen wesentlich reaktionsfähiger als die in B2(NMe2)4. Nucleophile und elektrophile Substitutionen an R2B2(NMe2)2 sind von einer Disproportionierung der Diborverbindung begleitet.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19633240303
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  • 9
    Electronic Resource
    Electronic Resource
    Beiträge zur Chemie des Bors. XXII. Darstellung und Eigenschaften einiger Alkyl-dimethylamino-borhalogenide (1963)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 324 (1963), S. 270-277 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Comproportionation of alkylborondihalides with alkyl-bis(dimethylamino)-boranes yields alkyl-dimethylamino-boronhalides, RB(X)NMe2. These dimerize more readily as the carbon chain of the alkyl groups and the size of the halogen atom decreases. The halogen atom in monomeric RB(X)NMe2 is easily replaced by other ligands.
    Notes: Alkyl-dimethylamino-borhalogenide, RB(X)NMe2, (X = Cl, Br) sind durch Komproportionierung von Alkylbordihalogeniden mit Alkyl-bis(dimethylamino)-boranen zugängig. Mit abnehmender Kettenlänge der Alkylgruppe und abnehmendem Radius des Halogens wächst die Tendenz zur Dimerisierung der monomeren Verbindungen. In diesen sind die Halogenatome leicht substituierbar.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19633240507
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  • 10
    Electronic Resource
    Electronic Resource
    1,3,4-Triaza-2,5-diborolidines (1964)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 3 (1964), S. 506-507 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.196405062
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    Paper (German National Licenses)
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