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  • 1990-1994  (3)
  • 1960-1964
  • Islets of Langerhans transplantation  (1)
  • Life and Medical Sciences  (1)
  • Lymphocele, renal transplantation  (1)
Source
Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Laparoscopic deroofing of post-transplant lymphoceles (1994)
    Springer
    Transplant international 7 (1994), S. 140-143 
    Details
    ISSN: 1432-2277
    Keywords: Lymphocele, renal transplantation ; Laparoscopic deroofing, lymphocele ; Renal transplantation, lymphocele
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lymphocele is a most common surgical complication following renal transplantation. The indication for treatment is given when the lymphocele becomes hyptomatic. We succeeded in laparoscopically deroofing large lymphoceles in nine patients that were causing ureter compression in eight and ipsilateral leg edema in six cases. The postoperative course was uneventful, and the surgery-related hospitalization did not exceed 7 days. Severe adhesions and a thick lymphocele wall, which made preparation difficult, resulted in the transection of the transplant ureter in one case. Techniques and prerequisites that would help to avoid this type of complication are discussed. According to CT scan or sonography, there was no recurrence in any of the patients after a mean follow-up of 11 months. This technique seems to be superior to other methods of treatment because not only is a cure obtained with a single intervention, but there is also a low risk of infection and a short hospitalization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00336477
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    In-vitro- und In-vivo-Studien zur Isolierung, Transplantation und Funktion von Langerhans-Inseln am Schwein (1990)
    Springer
    Langenbeck's archives of surgery 375 (1990), S. 259-265 
    Details
    ISSN: 1435-2451
    Keywords: Islets of Langerhans transplantation ; Pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Grenzen und Möglichkeiten der Transplantation von Langerhans-Inseln wurden am Schwein erprobt. Nach totaler Pankreatektomie wurden durch intraduktale Kollagenaseandauung zwischen 6mal 104 and 3mal 106 Inseln and inseltragende Fragmente pro Pankreas gewonnen. Nach Injektion des Transplantates in die Milz oder wahlweise in die Leber konnte bei den Tieren ein normoglykämischer Zustand mit normalen intravenösen Glukosetoleranztesten und ein Überleben bis zu 1 Jahr erreicht werden. Apankreatische Kontrollen verstarben im diabetischen Koma 10–12 Tage postoperativ. Eine gute Korrelation zwischen der Anzahl transplantierter Inseln und Normoglykämie nach Transplantation konnte demonstriert werden. Darüber hinaus war die synchrone In-vitro-Stimulation der Inseln mit Glukose und die daraus resultierende Inselsekretion ein wichtiger Indikator für die funktionelle Integrität der Inseln nach der Transplantation. Das Schwein bietet somit auch aufgrund der dem Menschen sehr ähnlichen immunologischen, physiologischen und anatomischen Eigenschaften bezüglich des Pankreas und der Ernährung ein gutes Modell zur weiteren präklinischen Erforschung der Inseltransplantation als Therapie des Diabetes mellitus.
    Notes: Summary Limits and possibilities of the transplantation of islets of Langerhans in pigs were studied. 6 × 104 to 3 × 106 islets and insulin producing fragments per pancreas were obtained by intraductal collagenase digestion of the pancreatic gland following total pancreatectomy. Islets grafted into the spleen or liver rendered normoglycemia to the pancreatectomized animals as demonstrated by normal fasting blood sugars and normal intravenous glucose tolerance tests as compared to not operated animals permitting a survival time of up to one year. Apancreatic controls died of ketoacidosis and diabetic coma 10 to 12 days posttransplant. The number of isolated and transplanted islets correlated well to the normoglycemic state of the animal. Beyond that the in vitro challenge of the islets with glucose and resulting insulin secretion was a very important indicator for the functional status and integrity of the islets after transplantation. Thus the pig appears to be a suitable model for the preclinical studying of islet transplantation especially since immunologic, physiologic and anatomic features of the pig are similar to those in the human regarding pancreas and nutrition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184165
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Early development of the human area postrema and subfornical organ (1992)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 232 (1992), S. 612-619 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The first appearance and early development of two circumventricular organs, the area postrema (AP) and the subfornical organ (SFO), were investigated in human embryos and fetuses from the 4th to the 40th gestational weeks (GW). The AP appears very early in development, during the GW 10; its high vascularization can be seen from GW14, and differentiated neurons are observed from GW 16. The SFO is characterized by a late onset of development. It can first be distinguished at GW 17, but it does not attain cytological differentiation until the last weeks of gestation. It is suggested that the AP has important functions during fetal life, which are related to normal fetal weight and growth; in contrast the SFO, which is connected with drinking behavior and salt/water balance, seems to play a less essential role in early fetal life.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092320416
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    Paper (German National Licenses)
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