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Estrogen and progesterone receptors in ovarian neoplasms: discrepant results of immunohistochemical and biochemical methods (1991)

Kommoss, F. ; Pfisterer, J. ; Geyer, H. ; [et al.]

Three Cambridge Center, Suite 208, Cambridge, MA 02142, USA : Blackwell Scientific Publications Inc.

International journal of gynecological cancer 1 (1991), S. 0

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ISSN: 1525-1438

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Ninety-five ovarian neoplasms were studied for ER and PR content by immunohistochemistry, and the results were compared to those of biochemical ER and PR determination in 89 cases. While there was no difference between the results of both methods of hormone receptor determination in the few non-epithelial tumors studied, there was only a low correlation between the semi-quantitative results of ER and PR immunohistochemistry, and the corresponding values of biochemical steroid receptor determination in 77 common epithelial carcinomas of the ovary. In a majority of cases with discordant results between both methods, tumors were hormone receptor positive by DCC analysis but negative by immunohistochemistry. The finding of ER or PR positive stromal cells without any evidence of hormone receptor positive epithelial tumor cells in such tumors offers a possible explanation for the apparent discrepancy. Ovarian carcinomas containing ER or PR positive epithelial tumor cells may constitute a smaller subgroup of all tumors thought to be hormone receptor positive when only results of biochemical methods of steroid receptor determination were available.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1525-1438.1991.01040147.x

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Untersuchungen über den Einfluß von Röntgenstrahlen auf Pyridoxalphosphat in Escherichia coli (1963)

Langendorff, H. ; Geyer, H.

Springer

Archives of microbiology 46 (1963), S. 1-8

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ISSN: 1432-072X

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Description / Table of Contents: Summary The estimation of pyridoxalphosphate in Escherichia coli after irradiation is described. The investigations are made with resting and growing cells. A dose of 10, 40 or 80 kr does not change the pyridoxal-content of the cell. In all cultures of E. coli starts the synthesis of pyridoxalphosphate at the same time on the end of the log-phase.

Notes: Zusammenfassung Um zu klären, ob der Tod von lebenden Zellen nach Röntgenbestrahlung auf eine Zerstörung des in der Zelle vorhandenen Pyridoxalphosphats und damit auf eine Blockierung der pyridoxalabhängigen Enzyme zurückzuführen ist, wurde in bestrahlten und unbestrahlten Escherichia coli der Pyridoxalphosphat-Gehalt bestimmt. Die Untersuchung wurde an ruhenden und wachsenden Zellen durchgeführt. Durch Bestrahlung mit 10,40 und 80 kr wird der Pyridoxalphosphat-Gehalt der Zelle nicht verändert. Alle Kulturen begannen zur gleichen Zeit am Ende der log-Phase des Wachstums mit der Neubildung von Pyridoxalphosphat.