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  • 1
    Electronic Resource
    Electronic Resource
    Die Bestimmung des Gesamtbilirubins in kleinsten Serummengen mit dem Ultramikro-Analytical-System (UAS) der FirmaBeckman/Spinco nach der Methode vonJendrassik undGróf (1964)
    Springer
    Journal of molecular medicine 42 (1964), S. 971-973 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Das Ultramikro-Analytische-System (UAS) der Firma Beckman/Spinco gibt die Möglichkeit, an 0,02–0,04 ml Serum Bilirubin zu bestimmen. Die von der Firma angegebene Bestimmungsmethode nachMalloy u.Evelyn und die Eichmethode mit einer Chloroformlösung genügen den heute gestellten Anforderungen nicht. Es wird deshalb die allgemein anerkannte Methode nachJendrassik u.Gróf für das System modifiziert. Die Gültigkeit des Beerschen Gesetzes wird durch Verdünnungsreihen bewiesen. Die Genauigkeit der Methode entspricht mit einer Fehlerbreite von ± 2–3% der üblicher Mikromethoden. Sie wird durch Hämolyse bei Messung gegen eine Serumvergleichslösung nicht gestört. Bei nicht hämolytischen, ungetrübten Seren höheren Bilirubingehaltes ist eine vereinfachte Messung gegen Wasser möglich. Die Eichung erfolgt am besten nach der Methode vonSchellong u.Wende. Diese darf jedoch nicht unkorrigiert übernommen werden. Lyophilisierte, stabile Seren hohen Bilirubingehaltes, dienen zur Kontrolle der Eichung und als stabiler Standard.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01484426
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  • 2
    Electronic Resource
    Electronic Resource
    Estrogen and progesterone receptors in ovarian neoplasms: discrepant results of immunohistochemical and biochemical methods (1991)
    Three Cambridge Center, Suite 208, Cambridge, MA 02142, USA : Blackwell Scientific Publications Inc.
    International journal of gynecological cancer 1 (1991), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ninety-five ovarian neoplasms were studied for ER and PR content by immunohistochemistry, and the results were compared to those of biochemical ER and PR determination in 89 cases. While there was no difference between the results of both methods of hormone receptor determination in the few non-epithelial tumors studied, there was only a low correlation between the semi-quantitative results of ER and PR immunohistochemistry, and the corresponding values of biochemical steroid receptor determination in 77 common epithelial carcinomas of the ovary. In a majority of cases with discordant results between both methods, tumors were hormone receptor positive by DCC analysis but negative by immunohistochemistry. The finding of ER or PR positive stromal cells without any evidence of hormone receptor positive epithelial tumor cells in such tumors offers a possible explanation for the apparent discrepancy. Ovarian carcinomas containing ER or PR positive epithelial tumor cells may constitute a smaller subgroup of all tumors thought to be hormone receptor positive when only results of biochemical methods of steroid receptor determination were available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1991.01040147.x
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  • 3
    Electronic Resource
    Electronic Resource
    Co-cultivation of ovarian carcinoma cells with dermal fibroblasts induces fibroblast expression of sex steroid receptor transcripts and protein (1995)
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachussetts 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 5 (1995), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have previously reported that stromal fibroblasts of ovarian carcinoma specimens may express estrogen (ER) and progesterone receptors (PR) when the malignant epithelial cells do not, and even when the specimens have been obtained from such non-Müllerian structures as the omentum whose fibroblasts normally express neither ER nor PR. In an attempt to investigate whether our observations of the expression of ER and PR in fibroblasts surrounding metastatic invasive epithelial ovarian carcinoma cells might result from an interaction involving malignant epithelial cells and stromal fibroblasts, we co-cultivated in vitro BG1 ovarian carcinoma cells with sex steroid receptor-negative dermal fibroblasts to determine whether carcinoma cells might induce the latter to express ER or PR protein and transcripts at levels detectable by standard immunocytochemical (ICC) and in situ hybridization (ISH) techniques. We report the in vitro induction of ER and PR transcripts and protein in previously steroid receptor-negative skin fibroblasts after co-cultivation with BG1 ovarian adenocarcinoma cells. Such observations suggest that a juxtacrine mechanism is responsible for the observed phenomenon, possibly involving ER- and PR-inducing factors (ER-IF and PR-IF).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1995.05020101.x
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  • 4
    Electronic Resource
    Electronic Resource
    Combined radio-chemotherapy in advanced cervical cancer: a phase-II trial with weekly applied carboplatin, 5-fluorouracil and folinic acid (1996)
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts, 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 6 (1996), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The 5-year survival of patients with advanced cervical cancer is poor. Major problems are the high frequency of pelvic recurrences and distant metastases. To prevent both, various efforts have been made to combine local radiotherapy with systemic chemotherapy. In this prospective study, 28 previously untreated patients with advanced cervical cancer (FIGO IIB-IVB) were treated with a newly designed therapy consisting of fractionated external beam irradiation (54 Gy) followed by two intracavitary cesium (Cs) applications (2 × 15 Gy), combined with carboplatin (70 mg m−2), 5-fluorouracil (5-FU) (400 mg m−2) and folinic acid (400 mg m−2). Cytotoxic agents were given intravenously on days 1, 8, 15, 22 and 29 as 1-day courses during external irradiation followed by three 3-day courses with carboplatin (100 mg m−2 i.v. daily), 5-FU (400 mg m−2 i.v. daily) and folinic acid (400 mg m−2 i.v. daily) after 8, 12 and 16 weeks of treatment.Acute toxicities ( 〈inlineGraphic alt="geqslant R: gt-or-equal, slanted" extraInfo="nonStandardEntity" href="urn:x-wiley:1048891X:IJG06010020:ges" location="ges.gif"/〉 WHO grade 2) were leucopenia (27 of 28 patients), diarrhea (23/28), abdominal pain (19/28), nausea (14/28) and skin desquamation (12/28). Clinically diagnosed pelvic response was achieved in 88.5% (23/26) with a complete response of 34.5% (9/26). As yet, 19 of 26 patients (73.1%) are alive and well (persistent complete/partial remission), two patients (7.7%) are alive with local progression, four (15.4%) have died from pelvic and/or distal recurrence and one (3.8%) died some weeks after the start of therapy. The combined modality treatment concept has to be considered for the therapy of advanced cervical cancer and a prospective and randomized trial with a greater number of patients is warranted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1996.06010020.x
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  • 5
    Electronic Resource
    Electronic Resource
    DNA flow cytometry in stage IB and II cervical carcinoma (1996)
    Suite 500, 5th Floor, 238 Main Street, Cambridge, Massachusetts, 02142, USA : Blackwell Science Inc.
    International journal of gynecological cancer 6 (1996), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a retrospective study the prognostic significance of nuclear DNA content was investigated, as measured by flow cytometry, of the tumor specimens from 212 women with nonpretreated FIGO stage IB and II cervical cancer. One-hundred and thirty cases (62%) were found to be diploid, whereas 82 (38%) were aneuploid. Univariate analysis of the follow-up data showed an increased relative risk (RR) for recurrence free survival (RFS) for stage II tumors (RR = 1.87, 95% CI: 1.13–3.10, P = 0.015) and for age (RR = 1.52, 95% CI: 0.66–3.52 and RR = 2.35, 95% CI: 1.19–4.65, P = 0.032). Ploidy showed a relative risk of 1.33 (95% CI: 0.83–2.13, NS). In addition, univariate analysis of overall survival (OS) revealed similar results. For the subgroup of patients with primary surgery (n = 151), positive pelvic nodes (RR = 5.38, 95% CI: 2.70–10.71, P = 0.0001) and parametrial extension (RR = 2.53, 95% CI: 1.24–5.17, P = 0.011) were significant factors for OS after univariate analysis, the estimated effects on RFS were slightly smaller. Multivariate analysis of RFS for the whole study population showed age, histologic grade and stage with a slightly increased risk, but no effect was significant. Ploidy with an RR of 0.97 (95% CI: 0.58–1.62) seems to have no influence on prognosis. For the subgroup with primary surgery, ploidy again failed statistical significance with an RR of 1.20 (95% CI: 0.58–2.49). Our results suggest that abnormalities of the nuclear DNA content in this homogeneous group of patients are associated with clinical and morphological prognosticators, however, ploidy is not an independent prognostic factor for RFS, or for the whole study population or for the subgroup with primary surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1996.06010054.x
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  • 6
    Electronic Resource
    Electronic Resource
    Relationship between epidermal growth factor receptor (EGF-R) and various prognostic factors in human endometrial carcinoma (1992)
    Three Cambridge Center, Massachusetts 02142, USA : Blackwell Scientific Publications Inc.
    International journal of gynecological cancer 2 (1992), S. 0 
    Details
    ISSN: 1525-1438
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eighty primary endometrial carcinomas were analyzed for the presence of epidermal growth factor receptors (EGF-R) by the use of a single point (1ng 125I-EGF) EGF-R assay. Fifty percent of the analyzed specimens were EGF-R positive (EGF-R(+)) with binding capacities 〉 1 fmol mg−1 and 15% bound 〉 7 fmol mg−1. The EGF-R status was correlated with different clinically relevant prognostic factors and the survival rates were analyzed. The correlations revealed no significant differences in the grade of tumor differentiation and in the depth of myometrial invasion. The advanced tumor stages III and IV and tumors with a squamous cell component in the histologic examination expressed EGF-R in a higher percentage. Between the EGF-R and the steroid receptor status existed a weak negative correlation. Estrogen receptor positive tumors were in 47% and progesterone receptor positive tumors in 45% EGF-R (+). The corresponding number for the receptor negative tumors were 57 and 65%. Life table analyses were performed with different cut-off limits for specific EGF binding ranging from 〉 1, 〉 3, 〉 5 and 〉 7 fmol mg−1. Dependent on the cut-off limits the analysis demonstrates a reduced survival probability for patients with EGF-R+ tumors. These differences were mainly found in the small group with a high number of EGF-R’s (〉 7 fmol). The analysis of tissue extracts for the presence of factors binding to the EGF-R revealed in some specimens high concentrations of EGF-like factors. By the use of TGFa (transforming growth factor alpha) immunohistochemistry we were able to demonstrate that the tumor cells produce TGFa, whereas the stroma is TGFa negative. We assume that the EGF-like factors consist mainly of TGFa.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1525-1438.1992.02020066.x
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  • 7
    Electronic Resource
    Electronic Resource
    Cytogenetic and molecular evidence for nonrandom loss of 11p material in human ovarian cancer
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 63 (1992), S. 147 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(92)90473-L
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  • 8
    Electronic Resource
    Electronic Resource
    Cytogenetic analysis of an adenoid cystic carcinoma of the Bartholin's gland - A rare, semimalignant tumor of the female genitourinary tract.
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 63 (1992), S. 153 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(92)90485-Q
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  • 9
    Electronic Resource
    Electronic Resource
    Cytogenetic analysis of an adenoid cystic carcinoma of the Bartholin's gland - A rare, semimalignant tumor of the female genitourinary tract
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 61 (1992), S. 26-30 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(92)90365-F
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  • 10
    Electronic Resource
    Electronic Resource
    Clinical relevance of estrogen- and progesteron receptors in endometrial cancer
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 59 
    Details
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(87)91270-2
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