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  • 1990-1994  (46)
  • 1955-1959  (16)
  • 1930-1934  (27)
  • 1915-1919  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cancer immunology immunotherapy 39 (1994), S. 148-154 
    ISSN: 1432-0851
    Keywords: Melanoma ; Antitumor response ; Interferon resistance ; rHuIFNαA/D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mouse B16 melanoma cells rapidly develop resistance to the antiproliferative effects of interferon α (IFNα) and interferon β (IFNβ) when they are exposed to the interferons in vitro. This resistance was characterized to be non-genetic and dose-dependent, and does not alter other IFN-induced effects such as antiviral effects and elevation of 2′,5′-oligoadenylate synthetase activity in IFN-treated cells. The study of these IFN-resistant cells has been extended to an in vivo tumor model. Resistance, if it occurred in vivo, did not adversely affect the survival of IFN-treated mice. Further, IFN-treated mice inoculated with B16 cells that were resistant in vitro (B16αres cells) survived significantly longer than IFN-treated mice inoculated with B16 cells that were sensitive in vitro. The IFN-treated B16αres-inoculated mice had a significantly higher cure rate as well. The prolonged survival of the mice bearing B16αres cell tumors did not seem to be caused by the slower growth rate of the B16αres cells, since experiments performed with a tenfold higher B16αres cell inoculum and a tenfold lower B16 cell inoculum did not show any change in the survival pattern. It is clear that in vitro resistant B16αres cells are more sensitive to antitumor effects induced by IFN in vivo than in vitro sensitive B16 cells.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cancer immunology immunotherapy 39 (1994), S. 148-154 
    ISSN: 1432-0851
    Keywords: Key words: Melanoma – Antitumor response – Interferon resistance – rHuIFNαA/D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Mouse B16 melanoma cells rapidly develop resistance to the antiproliferative effects of interferon α (IFNα) and interferon β (IFNβ) when they are exposed to the interferons in vitro. This resistance was characterized to be non-genetic and dose-dependent, and does not alter other IFN-induced effects such as antiviral effects and elevation of 2′,5′-oligoadenylate synthetase activity in IFN-treated cells. The study of these IFN-resistant cells has been extended to an in vivo tumor model. Resistance, if it occurred in vivo, did not adversely affect the survival of IFN-treated mice. Further, IFN-treated mice inoculated with B16 cells that were resistant in vitro (B16αres cells) survived significantly longer than IFN-treated mice inoculated with B16 cells that were sensitive in vitro. The IFN-treated B16αres-inoculated mice had a significantly higher cure rate as well. The prolonged survival of the mice bearing B16αres cell tumors did not seem to be caused by the slower growth rate of the B16αres cells, since experiments performed with a tenfold higher B16αres cell inoculum and a tenfold lower B16 cell inoculum did not show any change in the survival pattern. It is clear that in vitro resistant B16αres cells are more sensitive to antitumor effects induced by IFN in vivo than in vitro sensitive B16 cells.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 94 (1990), S. 1847-1850 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 69 (1991), S. 6313-6318 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Experimental studies of the reflection, transmission, and absorption of high-power microwave pulses from a plasma-covered plane conducting boundary are presented. Under optimum conditions, backscattered rf power is attenuated by more than 30 dB over values measured in the absence of the plasma. Measurements of the radial and axial plasma density profiles and the neutral gas pressure near the plane conductor indicate that collisional absorption processes are not the primary source of the observed attenuation in the backscattered microwave signal, and that the plasma density exceeds the critical density over much of the volume nearest the conductor. The effects of a tenfold reduction in the microwave power density on the reflection and absorption characteristics of the system are also reported.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 94 (1991), S. 3730-3734 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The results of ab initio electronic structure calculations on the C60 cage and its endohedral ("inside-the-cage'') complexes with F−, Ne, Na+, Mg2+, and Al3+ are presented. Placing the ions at the center of the cage results in a net stabilization and screening of the charges. The ionic guests either decrease (F−) or increase (Na+, Mg2+, and Al3+ ) the cage radii. The complexes with the ions at the cage center are local maxima with respect to the displacement of the guests. The C60⋅Ne complex, which is destabilized by ca. 0.4 kcal/mol relative to the separated components, is an energy minimum. In the C60⋅Na+ complex, the energy minimum (which lies only 0.8 kcal/mol below the maximum) corresponds to the Na atom displaced by 0.66 A(ring) from the cage center. The calculated properties of the endohedral complexes are easily rationalized with a model involving a double-layer polarizable C60 cage affected by the electrostatic potential produced by the enclosed guests.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 4751-4755 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 64-67 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 113 (1991), S. 1086-1089 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 2 (1990), S. 554-560 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A numerical analysis was performed of guiding-center (gc) orbits in a variety of spheromak-type force-free, numerically determined equilibria including the normal spherical configurations as well as configurations that are more prolate and oblate, and others having hollow or peaked current profiles. The calculated drift orbits differ significantly from the well-known drift orbits in tokamaks. In particular, the results indicate (i) the existence of particles trapped in separate hemispheres, (ii) the orbit widths d are about proportional to the Larmor radius ρ of the particle (calculated for the field maximum) up to ρ≈0.01–0.02 of the major separatrix dimension, (iii) many orbits, in particular on the outer flux lines, have their maximum normalized width dmax/ρL(ρL= local Larmor radius) away from the midplane of the configuration, and (iv) these maximum normalized widths are about 2–4 over most of the volume for all configurations except for prolate ones with a peaked current profile; in the latter configurations, orbits on outer field surfaces show dmax≤ρL.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 55 (1990), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Nondestructive physical property measurements, such as kernel size, sphericity, specific gravity and elastic deformation were evaluated as indicators of the popping characteristics of microwave popcorn. A greater expansion volume was observed in varieties having sphericity values greater than 0.70. Within a given variety, larger kernel sizes resulted in a lower unpopped kernel ratio and the expansion volume and flake size were higher for kernels with a higher specific gravity. The elastic deformation was found to have no correlation with microwave popping.
    Type of Medium: Electronic Resource
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