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  • 1
    Electronic Resource
    Electronic Resource
    Selective intra-lysosomal concentration of niobium in kidney and bone marrow cells: a microanalytical study (1993)
    Springer
    BioMetals 6 (1993), S. 17-23 
    Details
    ISSN: 1572-8773
    Keywords: bone marrow ; kidney ; lysosome ; niobium ; X-ray microanalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Niobium is used as an alloy in the industrial and biomedical fields. The concentration of the toxic element in organs of a number of animal species has been defined by using radioactive niobium (95Nb). However, tissue lesions induced by niobium have only been studied at the light microscopy level. In this study, we used an electron probe X-ray analyzer equipped with a transmission electron microscope to define the localization of this element in kidney and bone marrow cells. Results demonstrated that niobium is located in the lysosome and that this element coprecipitates with phosphate. In kidney, lysosomes and precipitates are eliminated in the tubular lumen. In contrast, precipitates appear to be eliminated more slowly from the lysosomes of bone marrow macrophages. These processes therefore correspond to one of the mechanisms by which lysosomes eliminate certain toxic mineral elements and thus play a role in the more general process of the body's defenses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00154228
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  • 2
    Electronic Resource
    Electronic Resource
    Further evidence for abnormal protein kinase C regulation of macromolecule secretion in fibroblasts from cystic fibrosis patients (1990)
    Springer
    Bioscience reports 10 (1990), S. 563-572 
    Details
    ISSN: 1573-4935
    Keywords: cystic fibrosis ; protein kinase C ; glycoconjugate secretion ; phorbol esters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In comparison to skin fibroblasts from normal subjects, those from patients with cystic fibrosis (CF): (1) bound [20-3H] phorbol 12,13-dibutyrate (PDBu) with a higher affinity (Kd=25.8 vs 12.8 nM respectively) but expressed a similar number of total phorbol ester binding sites (about 2.5 pmol PDBu bound/mg of protein); (2) exhibited a faster and higher response to 4β-phorbol 12β-myristate 13α-acetate (PMA) for the stimulation of [35S]-labelled glycoconjutate release, but were equally sensitive to the synergistic effect of A23187 on this process; and (3) secreted glycoconjugates with similar [35S]-sulfate and [14C]-leucine to [14C]-glucosamine labelling ratios. Taken together, these results provide further evidence for abnormal protein kinase C (PKC) regulation of macromolecule secretion in CF disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116617
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A French case of rabies in Europe (1992)
    Springer
    European journal of clinical microbiology & infectious diseases 11 (1992), S. 479-479 
    Details
    ISSN: 1435-4373
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01961873
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Der Einfluß von Elektrolyten auf den Hochdruck (1952)
    Springer
    Basic research in cardiology 18 (1952), S. 156-161 
    Details
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Salzentzug scheint auf Hochdruck nicht so sehr durch Veränderungen des Natriumstoffwechsels an und für sich zu wirken, sondern viel eher durch Verschiebung der Stoffwechselgleichgewichte, durch direkte Beeinflussung oder indirekten Effekt auf die endokrinen Funktionen und die Zirkulationsdynamik, das heißt, es wird durch den Salzentzug eine gesamthafte Umstellung der physiologischen Bedingungen im Organismus erzeugt. 2. Wie es schon Kempner (31) versucht hatte, sollte man durch nähere Erforschung der erwähnten Zusammenhänge zu einer wirksameren, spezifisch auf Hochdruck gerichteten Umstellung gelangen, welche Aussicht auf besseren Erfolg hätte. Salzentzug allein genügt nicht, es müssen noch weitere Maßnahmen in die Hochdruckdiät einbezogen werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02119168
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic analysis of resistance of five melon lines to powdery mildews (1992)
    Springer
    Euphytica 65 (1992), S. 135-144 
    Details
    ISSN: 1573-5060
    Keywords: allelism relationships ; Cucumis melo ; Erysiphe cichoracearum ; genetic control ; melon ; Sphaerotheca fuliginea ; pathotypes ; powdery mildew
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Inheritance of resistance of five melon lines to two strains of Sphaerotheca fuliginea belonging to races 1 (Sf1) and 2 (Sf2) and to one strain of Erysiphe cichoracearum (Ec) have been studied. ‘PMR 45’ possesses one dominant gene controlling only Sf1. ‘WMR 29’ has one dominant gene for resistance to Sf1 and another for Sf2 and these genes seem to be linked. In line ‘PMR 5’, one dominant gene (or a group of three closely linked genes) is involved in the control of the three strains with one complementary gene for Sf1 and another one for Ec. ‘PI 124112’ has one dominant gene or two closely linked loci controlling Sf1 and Sf2 and two complementary different genes controlling Ec. ‘Nantais Oblong’ has one dominant gene controlling only Ec. A nomenclature of the genes described is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00022575
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  • 6
    Electronic Resource
    Electronic Resource
    Parallel finite element computations on a network using NCS (1992)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 38 (1992), S. 251-258 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Research has been carried out on the use of NCS (Network Computing System) to distribute the processing of a finite element application to multiple computers at once. Coarse-grained parallelism of specific routines on loosely coupled CPUs has been implemented and tested. In a step-by-step fashion, the method of using NCS to convert finite element software POLY2D is explained for its application in parallel computing resources throughout a network. For the modeling of a simple conductive heat transfer problem, the distributed version of POLY2D on a homogeneous token ring network of nine Apollo workstations is used. Some timings given are compared to those obtained from a standard nondistributed simulation.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690380211
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  • 7
    Electronic Resource
    Electronic Resource
    Finite element analysis of viscous mixing with a helical ribbon-screw impeller (1992)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 38 (1992), S. 939-944 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A finite element analysis was carried out to study the mixing patterns of a viscous Newtonian fluid into a stirred tank. A helical ribbon screw impeller (HRS) was used as the mixing device. The numerical simulation involved the full three-dimensional resolution of the equations of change governing the flow in the tank. The circulation time and the torque were determined and compared with experimental data. A good agreement was found, showing the usefulness of the numerical approach for design purposes.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690380614
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  • 8
    Electronic Resource
    Electronic Resource
    Tetrahedral elements for fluid flow (1992)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 33 (1992), S. 1251-1267 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Several old and new tetrahedral elements are tested and compared to some classical hexahedral elements for the solution of three-dimensional incompressible fluid flow problems. The proposed elements are created by adding velocity degrees of freedom to the basic trilinear velocity, constant pressure tetrahedron so as to satisfy the Brezzi condition. Numerical tests carried out for an artificial divergence-free flow problem and the lid-driven cubic cavity up to a Reynolds number of 400 are used to compare the proposed elements and assess their accuracy.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620330610
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  • 9
    Electronic Resource
    Electronic Resource
    A decomposed Crouzeix-Raviart element for the finite element solution of the Navier-Stokes equation (1991)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 13 (1991), S. 1073-1083 
    Details
    ISSN: 0271-2091
    Keywords: Crouzeix-Raviart ; Analytical integration ; Brezzi-Babuška condition ; Navier-Stokes ; Finite element method ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A methodology for the decomposition of the Crouzeix-Raviart finite element into six linear subelements is described. The resulting element is shown to satisfy the Brezzi-Babuška compatibility condition. The error bounds are also established. A comparison in accuracy between this and the standard Crouzeix-Raviart element is presented for driven cavity flows. Other results include the execution time for the DCR element and the Crouzeix-Raviart element along with both analytical and numerical integration. It is shown that the decomposed element results in shorter execution times with only marginal changes in accuracy.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650130902
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