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  • 1990-1994  (16)
  • 1945-1949  (1)
  • 1940-1944  (2)
  • 1
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 85 (1943), S. 257-266 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Zusammenfassung 1. Da sowohl die Motive für das Tabakrauchen als auch die Geschmacksurteile bei den verschiedenen Rauchern sehr verschieden sind, ist eine allgemeingültige Reihung der Tabaksorten nach dem Genuß, den sie vermitteln, unmöglich. 2. Inhaltstoffe des Tabakblattes, deren Anwesenheit von einem größeren oder kleineren Kreis von Rauchern als angenehm empfunden wird, können auf die gleichen Raucher die gegenteilige Wirkung hervorbringen, wenn ihr mengenmäßiger Anteil zu hoch wird. 3. Auch nach dieser Einschränkung besteht keine Berechtigung, zwischen der Menge der Gesamtharze und der Qualität des Tabakes irgendeine allgemeingültige Beziehung herzustellen, weil die Wirkung der einzelnen Komponenten des Harzgemisches von den Rauchern verschieden beurteilt wird. Einzelne Bestandteile üben nach dem Empfinden verschiedener Raucher sogar eine nachteilige Wirkung aus. 4. Ein hoher Harzgehalt ist vom hygienischen Standpunkte aus unerwünscht, weil die Harze in besonderem Maße die Zusammenballfähigkeit des Rauches und damit die Ablagerung der Nicotinsalze im Körper des Rauchers fördern. 5. Es besteht keine Berechtigung, den als „Alkoholmethode” bezeichneten Arbeitsgang als geeignete Methode zur quantitativen Bestimmung der Tabakharze anzusehen, weil außer den wechselnden Mengen von ätherischen Ölen noch verschiedene Inhaltstoffe des Tabakblattes, die mit Harzen überhaupt nichts zu tun haben, zur Auswaage kommen können.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Key engineering materials Vol. 89-91 (Aug. 1993), p. 237-244 
    ISSN: 1013-9826
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 366 (1993), S. 215-215 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Coronary heart disease and atherosclerosis are the most frequent causes of death among men. Because these conditions occur more frequently in men than in women, it is often assumed that androgens play a causative role. Indeed, correlations between circulating testosterone levels and ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 50 (1994), S. 830-832 
    ISSN: 1420-9071
    Keywords: BPDZ 44 ; diazoxide ; 86Rb/45Ca fluxes ; insulin release ; rat pancreatic islets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The present study aimed at comparing the effects of low concentrations of BPDZ 44, a new pyridothiadiazine derivative, and diazoxide on86Rb outflow,45Ca outflow,45Ca uptake and insulin release from rat pancreatic islets. Both drugs caused similar modifications, but the effects of BPDZ 44 on the cationic and secretory events were much more marked than those of diazoxide. It is suggested that BPDZ 44 could be valuable tool for further studies of the KATP channels.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 65 (1994), S. 395-399 
    ISSN: 1432-1246
    Keywords: Lead ; Lead alkyls ; Tetraethyl lead ; Triethyl lead ; Diethyl lead
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dependent on the level of occupational exposure to tetraethyl lead, the occurrence of early signs of toxicity and the urinary excretion of triethyl lead, diethyl lead and total lead compounds were investigated. This was done in the following cohorts in the province of Hubei, China: 277 workers at gasoline depots exposed to gasoline, 36 traffic policemen exposed to automobile ex haust and 342 public office workers (virtually non-exposed controls). Mean external tetraethyl lead exposure concentrations were 84.8 μg/m3 (as Pb) for the gasoline depot workers, 5.2 μg/m3 for traffic police and 1.1 μg/m3 for the controls. No significant subclin organic lead toxicity were found in the group of traffic policemen compared with the controls. In the cohort of gasoline workers, however, there was a statistical increase (vs controls) in the frequency of appearance of tremor and of sinus bradycardia. When the cohort of gasoline workers was divided into subgroups of different ranges of exposure, dose-dependence was noted. In general, the urinary excretion of triethyl lead was very low compared to that of diethyl lead, which appears to be a sensitive and specific indicator of exposure to tetraethyl lead; total lead excretion did not correlate well with actual external tetraethyl lead exposure. On the basis of these data it seems that current occupational exposure limits for tetraethyl lead are inadequate and need to be revised. In addition, a biological limit, based on urinary diethyl lead excretion, may be proposed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Archives of toxicology 66 (1992), S. 45-50 
    ISSN: 1432-0738
    Keywords: Chromium(VI) ; Ascorbic acid ; Human plasma ; Reduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the metabolism of chromium(VI) its reduction in human plasma is of importance; an extracellular reduction of Cr(VI) is regarded as a detoxification step. Ascorbic acid has been suggested to represent the majority of the Cr(VI)-reducing capacity of human plasma. Therefore the kinetics of the reaction of Cr(VI) with ascorbic acid, at biologically realistic concentrations were studied. Ascorbic acid, in 0.2 M HEPES buffer and at concentrations ranging from 14.2 to 113.6 nmol ml−1 (2.5–20.0 μg ml−1), was mixed with Cr(VI) (0.4–1.5 nmol ml−1) and incubated at pH 7.4 and 37° C. In addition, chromate solutions at different concentrations [1.5–100 nmol ml−1 Cr(VI)], were incubated at 37° C with freshly drawn blood. From these incubates, ascorbic acid and its oxidized form, dehydroascorbic acid, were simultaneously analyzed by HPLC and post-column derivatization. Chromate was determined by flow injection analysis. The reaction kinetics of ascorbic acid in HEPES buffer with Cr(VI) is of pseudofirst order at higher concentrations, whilst apparently at lower concentrations kinetics are consistent with an autocatalyzed reaction. Results obtained after spiking human plasma are similar. However, when Cr(VI) was reacted with human plasma, no changes in the intrinsic contents of ascorbic acid of the plasma samples occurred. Also, comparing different plasma samples the intrinsic plasma contents of ascorbic acid and the reduction capacities for Cr(VI) [ranging between 0.48 and 0.63 nmol ml−1 Cr(VI) to be reduced] did not correlate. This shows that the reduction of Cr(VI) in native human plasma is complex and is not only determined by the plasma ascorbic acid levels. This is in contrast to the situation in lung lavage fluids (Suzuki 1988; Suzuki and Fukuda 1990) where the concentrations of ascorbic acid are much higher than in blood.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0738
    Keywords: Key words: Ethylene oxide – Polyglycol ethers – Skin-care products – Risk assessment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Ethylene oxide (EO) occurs as a contaminant of skin-care products because current commercial preparations of polyglycol ethers may contain ethylene oxide monomer residues, up to the order of 1 ppm. Using current regulatory worst-case assumptions, the presence of EO in skin-care products might lead to a maximal human daily external ethylene oxide dose of about 2.8 μg, and a consecutive maximal daily absorbed dose of 0.39 μg. Two methods of toxicokinetic analysis have been used to compare this possible EO load by use of skin-care products with the inevitable load of EO which is produced endogenously in the organism. On the basis of a previous assessment of the endogenous production of ethylene and ethylene oxide (Filser et al. 1992) it is inferred that the absorbed EO dose of 0.39 μg is about 1/30 of the unavoidable human endogenous load by endogenous EO. Alternatively, for a second calculation molecular dosimetry data have been used which were based on experimental quantification of the hydroxyethyl adduct of EO to the N-terminal valine of hemoglobin (HOEtVal) in rats. If the worst-case assumptions for human EO absorption from skin-care products are transferred to the rat species, the associated internal EO doses are about 1/110 of the internal EO doses which were calculated from the background HOEtVal concentrations observed in untreated animals. The divergence between both lines of calculation is mainly due to differences in HOEtVal background concentrations between man and rat. It is concluded that the additional internal body burden of EO associated with the use of current skin-care products, even under a series of worst-case assumptions, is neglegible compared to the physiological and unavoidable internal EO burden of the organism.
    Type of Medium: Electronic Resource
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