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  • 1990-1994  (2)
  • 1940-1944
  • 65M55  (1)
  • Oligonucleotides  (1)
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  • 1990-1994  (2)
  • 1940-1944
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Computing 49 (1992), S. 11-23 
    ISSN: 1436-5057
    Keywords: 65M55 ; 65Y05 (primary) ; 65M60 (secondary) ; Domain decomposition ; parallel time stepping ; parabolic problems ; transputer system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Die Implementierung von Lösungs-methoden für parabolische Probleme erfordert eine ausreichende Balance zwischen der parallelen Effizienz voll-expliziter Schemata und der Notwendigkeit von Stabilität und Genauigkeit, welche einen gewissen Grad an Implizitheit bedingt. Als ein Kompromiß wird ein Gebietszerlegungsverfahren vorgeschlagen, welches lokal implizit ist auf leicht überlappenden Teilgebieten, die lokalen Randdaten aber durch einen einfachen expliziten Prozeß fortpflanzt. Die Analyse dieses Algorithmus zeigt, daß er zufriedenstellende Stabilitäts- und Approximationseigenschaften besitzt und effektiv parallelisiert werden kann. Diese theoretischen Resultate werden bestätigt durch numerische Tests auf einem Transputer-System.
    Notes: Abstract In the parallel implementation of solution methods for parabolic problems one has to find a proper balance between the parallel efficiency of a fully explicit scheme and the need for stability and accuracy which requires some degree of implicitness. As a compromise a domain splitting scheme is proposed which is locally implicit on slightly overlapping subdomains but propagates the corresponding boundary data by a simple explicit process. The analysis of this algorithm shows that it has satisfactory stability and approximation properties and can be effectively parallelized. These theoretical results are confirmed by numerical tests on a transputer system.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 72 (1994), S. 737-741 
    ISSN: 1432-1440
    Keywords: Hepatitis B ; Antiviral agents ; Oligonucleotides ; Antisense
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chronic infection with the hepatitis B virus is a major health problem worldwide. The only established therapy is interferon-α, with an efficacy of only 30–40% in highly selected patients. Nucleoside analogues do not show a significant clinical benefit. Molecular therapeutic strategies aimed at blocking gene expression include antisense DNA/RNA and ribozymes acting at the posttranscriptional level and triple helix formation blocking at the transcriptional level. In vitro, antisense oligodeoxynucleotides inhibit viral replication and gene expression in human hepatoma cell lines. In vivo, an antisense oligodeoxynucleotide directed against the 5′-region of the pre-S gene of the duck hepatitis B virus inhibited viral replication and gene expression in ducks. In vitro, ribozymes accurately cleave HBV substrate RNA. Triple helix formation is another very promising molecular approach. Results in hepadnaviral infection are not yet available, however.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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