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  • 1
    Electronic Resource
    Electronic Resource
    Intrathecal ACNU treatment of B16 melanoma leptomeningeal metastasis in a new athymic rat model (1992)
    Springer
    Journal of neuro-oncology 14 (1992), S. 169-175 
    Details
    ISSN: 1573-7373
    Keywords: leptomeningeal metastasis ; meningeal carcinomatosis ; B16 melanoma ; intrathecal chemotherapy ; ACNU
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate new cytotoxic drugs for intrathecal treatment we developed an experimental model of leptomeningeal metastasis by intracisternal injection of 104B16-F10 melanoma cells in nude rats. One hour in vitro incubation with 20 μg/ml ACNU (area under the drug concentration-time curve = 1200 μgxmin/ml) induced a 4-log kill of B16 melanoma cells. A single or repeated non-toxic dose of 1 mg/kg was injected into the cisterna magna of rats inoculated with tumor (area under the drug concentration-time curve assuming an even cerebrospinal fluid distribution 〉 7000 μgxmin/ml). Median survival free of symptoms was 16 days (range 14–27) for controls (n = 9) and 18 days (range 17–23) for rats treated with ACNU on day 4 (n = 9). Animals treated both on day 2 and 8 (n = 8) developed symptoms on day 21 (range 13–35). Neurological symptoms and neuropathological examination in animals with increased survival indicated local suppression of tumor growth in the cisterna magna but increased spinal seeding and mass growth. From these results and the available pharmacokinetic data on ACNU it is concluded that bolus injection of ACNU — although locally effective — is not a sufficient treatment of widespread leptomeningeal metastasis. An increased therapeutic efficacy might be achieved by ventriculolumbar perfusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00177621
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    MR imaging of experimental meningeal melanomatosis in nude rats (1992)
    Springer
    Journal of neuro-oncology 14 (1992), S. 207-211 
    Details
    ISSN: 1573-7373
    Keywords: leptomeningeal metastasis ; B16 melanoma ; magnetic resonance imaging ; animal model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract MR imaging of the rat brain has become an increasingly frequently used method in experimental neuroradiology. On a generally available 1.5 T whole body tomograph, supplemented with an individually made small coil and a special SE sequence we obtained fairly fine images of the structures of the rat brain. With gadolinium-DTPA, we were able to visualize posterior fossa and cervical leptomeningeal growth of intrathecally injected B16 melanoma in nude rats. Using MRI to follow experimental leptomeningeal metastasis, may provide a new means for diagnostic evaluation and preclinical testing of treatment modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172596
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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