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  • 1990-1994  (2)
  • Drug-induced cerebral blood flow changes  (1)
  • phorbol esters  (1)
  • (Human monocyte-derived macrophage)
  • (Liver)
  • 1
    Electronic Resource
    Electronic Resource
    Further evidence for abnormal protein kinase C regulation of macromolecule secretion in fibroblasts from cystic fibrosis patients (1990)
    Springer
    Bioscience reports 10 (1990), S. 563-572 
    Details
    ISSN: 1573-4935
    Keywords: cystic fibrosis ; protein kinase C ; glycoconjugate secretion ; phorbol esters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract In comparison to skin fibroblasts from normal subjects, those from patients with cystic fibrosis (CF): (1) bound [20-3H] phorbol 12,13-dibutyrate (PDBu) with a higher affinity (Kd=25.8 vs 12.8 nM respectively) but expressed a similar number of total phorbol ester binding sites (about 2.5 pmol PDBu bound/mg of protein); (2) exhibited a faster and higher response to 4β-phorbol 12β-myristate 13α-acetate (PMA) for the stimulation of [35S]-labelled glycoconjutate release, but were equally sensitive to the synergistic effect of A23187 on this process; and (3) secreted glycoconjugates with similar [35S]-sulfate and [14C]-leucine to [14C]-glucosamine labelling ratios. Taken together, these results provide further evidence for abnormal protein kinase C (PKC) regulation of macromolecule secretion in CF disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116617
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of intravenously administered lidocaine on cerebral blood flow in a baboon model standardized under controlled general anaesthesia using single-photon emission tomography and technetium-99m hexamethylpropylene amine oxime (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 1095-1098 
    Details
    ISSN: 1619-7089
    Keywords: Ventilated anaesthetised baboon model ; Technetium-99m hexamethylpropylene amine oxime single-photon emission tomography ; Drug-induced cerebral blood flow changes ; Lidocaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The baboon under general anaesthesia as a model to assess drug-induced cerebral blood flow changes (Δ CBF) using single-photon emission tomography (SPET) offers great in vivo possibilities but has to comply with demands on control of anaesthesia-related influencing factors, such as P aCO2 changes. The model sought in this study and described here allows control of P aCO2, in the baboon under thiopentone anaesthesia by ventilation, and was evaluated for the functional dependence of Δ CBF vs Δ P aCO2, using SPET technetium-99m hexamethylpropylene amine oxime (HMPAO) and the split-dose method together with controlled ventilation. During the experiment the model was validated for normal reactivity to P aCO2 changes, and subsequently applied to investigate the mechanisms (still uncertain) of CBF increase known to follow administration of the local anaesthetic lidocaine. Six baboons received 6 mg/kg lidocaine intravenously. CBF was measured between two consecutive SPET acquisitions (split-dose method) respectively relating to HM-PAO distributions in the brain before and after the injection of lidocaine. Meanwhile the animals were maintained at constant respiratory rate and volume. The results indicate that the correlation between Δ CBF and the ensuing fall in PaCO2 deviated from the baseline pattern from the model and confirmed a cerebrovascular contribution to the lidocaine-induced CBF increase. This agreed well with mean and systolic blood pressure changes and heart rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173489
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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