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  • 1
    Electronic Resource
    Electronic Resource
    Levels excited in73Ge by (d, p) and (p, p′) reactions (1969)
    Springer
    The European physical journal 218 (1969), S. 137-152 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Angular distributions from the reactions72Ge(d, p)73Ge and73Ge(p, p′)73Ge have been studied with 8.0 MeV deuterons and 12.0 MeV protons, respectively, using the Aldermaston Tandem Van de Graaff generator and multi-angle magnetic spectrograph. The ground stateQ-value of the (d, p) reaction was measured to be 4.571±0.004 MeV. The energies, values of the transferred orbital angular momenta, parities and transition strengths in both reactions were determined by use of distorted-wave Bornapproximation calculations, for levels up to 3 MeV excitation energy. The sums of the transition strengths are compared with shell model calculations as well as with values obtained in neighbouring nuclei. Discrepancies between parity and possible spin assignments of states observed in the two reactions are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01669335
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Investigation by scintigraphic methods of neutrophil kinetics under normal and septic shock conditions in the experimental baboon model (1990)
    Springer
    European journal of nuclear medicine 16 (1990), S. 643-647 
    Details
    ISSN: 1619-7089
    Keywords: Labelled neutrophil kinetics ; Septic shock ; Baboon model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this study was the correlation of neutrophil kinetics with the pathogenic course of septic shock in the baboon model. Radioactively labelled neutrophils were traced in vivo in normal baboons (n= 6) and inEscherichia coli-infected baboons, which were reinjected with labelled autologous neutrophils either 2 h after the onset of theE. coli infusion (procedure A) (n= 3) or simultaneously with the infusion (procedure B) (n=3). Cell isolation was done according to a method developed in this laboratory. The cells were labelled with tropolonate In 111. resuspended in 1–2 ml plasma and reinjected. One-minute images were taken every 5th min and then hourly for 4 h with a gamma camera and analysed with a data processor. Time-activity curves were obtained for neutrophil washout from the lungs and neutrophil accumulation in the liver and spleen. These curves were compared for normal baboons and for those treated according to procedures A and B. A significant retention of neutrophils in the lungs of baboons withE. coli-induced septic shock was noted as well as an abnormally slow rate of accumulation in the liver and spleen. It also seems that any lung injury which could be attributed to changes in neutrophil behaviour should be traced back to events during the early exposure of neutrophils to bacterial infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00998163
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of intravenously administered lidocaine on cerebral blood flow in a baboon model standardized under controlled general anaesthesia using single-photon emission tomography and technetium-99m hexamethylpropylene amine oxime (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 1095-1098 
    Details
    ISSN: 1619-7089
    Keywords: Ventilated anaesthetised baboon model ; Technetium-99m hexamethylpropylene amine oxime single-photon emission tomography ; Drug-induced cerebral blood flow changes ; Lidocaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The baboon under general anaesthesia as a model to assess drug-induced cerebral blood flow changes (Δ CBF) using single-photon emission tomography (SPET) offers great in vivo possibilities but has to comply with demands on control of anaesthesia-related influencing factors, such as P aCO2 changes. The model sought in this study and described here allows control of P aCO2, in the baboon under thiopentone anaesthesia by ventilation, and was evaluated for the functional dependence of Δ CBF vs Δ P aCO2, using SPET technetium-99m hexamethylpropylene amine oxime (HMPAO) and the split-dose method together with controlled ventilation. During the experiment the model was validated for normal reactivity to P aCO2 changes, and subsequently applied to investigate the mechanisms (still uncertain) of CBF increase known to follow administration of the local anaesthetic lidocaine. Six baboons received 6 mg/kg lidocaine intravenously. CBF was measured between two consecutive SPET acquisitions (split-dose method) respectively relating to HM-PAO distributions in the brain before and after the injection of lidocaine. Meanwhile the animals were maintained at constant respiratory rate and volume. The results indicate that the correlation between Δ CBF and the ensuing fall in PaCO2 deviated from the baseline pattern from the model and confirmed a cerebrovascular contribution to the lidocaine-induced CBF increase. This agreed well with mean and systolic blood pressure changes and heart rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00173489
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Species and immunoglobulin preparation related effects on the biodistribution of technetium-99m-labelled immunoglobulin G in a baboon model (1993)
    Springer
    European journal of nuclear medicine 20 (1993), S. 96-100 
    Details
    ISSN: 1619-7089
    Keywords: Technetium-99m-labelled immunoglobulin G preparation ; Scintigraphy ; Baboon model ; Biodistribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Technetium-99m-labelled immunoglobulin G (99mTc-IgG) is a convenient and useful radio-pharmaceutical for the scintigraphic detection of inflammatory foci. However, unfavourable physiological biodistribution patterns such as high activities in the liver and especially in the kidneys impede the efficacy of this agent. This report describes biodistribution studies in the baboon model of various thiol reduction-mediated 99mTc-labelled immunoglobulins, including human IgG preparations (Sandoglobulin and Sigma: γ-globulins prepared from Cohn fractions II and III) as well as baboon IgG preparations (Sigma: γ-globulins prepared from Cohn fractions II and III and IgG isolated from the serum obtained from specific animals). The biodistribution studies demonstrated differences in kidney concentration, i.e. human IgG (Sandoglobulin) 〉 baboon IgG (cross-over animal experiments with IgG isolated from the serum of the different animals) 〉 human IgG (Sigma)≈ baboon IgG (Sigma)≈baboon IgG (own IgG isolated from the serum of a specific animal, labelled with 99mTc and reinjected). Differences in liver concentration were also observed: human IgG (Sandoglobulin)〈human IgG(Sigma)≈baboon IgG (Sigma)≈baboon IgG (own IgG)≈IgG (cross-over). Characteristic were the relatively high activities in the liver and kidneys compared to those in other organs with high blood supply, and a relatively high retention in the blood pool. The results indicate that the effect of the heterologous antibody system is insignificant. These studies also demonstrate the suitability of the baboon model for evaluation of 99mTc-IgG preparations for scintigraphic purposes and suggest that damage to the Fc portion of the IgG molecule during Sandoglobulin preparation may be the cause of the high kidney accumulation of 99mTc-Sandoglobulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168867
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Elastic scattering of6Li on6Li in the energy rangeE CM=2–10MeV (1973)
    Springer
    The European physical journal 265 (1973), S. 411-420 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In a coincidence experiment, two excitation functions (0cm=60° and 90°) and four angular distributions of the differential cross section for the elastic scattering of6Li on6Li were measured. The energy range for the excitation functions was from 2 to 10 MeV (CM), the angular distributions were taken at CM-energies of 4, 5, 6, 7.25 MeV. Optical model calculations were performed. It is shown that the outer portion of the potentials is most important for reproducing the experimental data.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01391616
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    Paper (German National Licenses)
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