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  • 1
    Electronic Resource
    Electronic Resource
    PET studies with l-[1-11C]tyrosine, l-[methyl-11C]methionine and 18F-fluorodeoxyglucose in prolactinomas in relation to bromocryptine treatment (1991)
    Springer
    European journal of nuclear medicine 18 (1991), S. 453-460 
    Details
    ISSN: 1619-7089
    Keywords: Positron emission tomography ; 11C-amino acids ; 18F-fluorodeoxyglucose ; Prolactinoma ; Salivary gland
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aspects of metabolism in prolactinomas were investigated by positron emission tomography using l-[1-11C]tyrosine, l-[methyl-11C]methionine and 18F-fluorodeoxyglucose (18FDG). Using l-[1-11C]tyrosine, four patients were monitored prior to and 18 h after an injection of 50 mg bromocryptine. At 18 h after bromocryptine intervention, l-[1-11C]tyrosine uptake into tumour was reduced with 28% (P〈0.07). A correlation analysis of the bromocryptine-induced decrease in l-[1-11C]tyrosine uptake and the reduction of serum prolactin levels indicated that the action of bromocryptine on prolactin synthesis and prolactin release is not coupled. In the untreated situation, the four patients were investigated with 18FDG as well, but the prolactinomas could not be visualized. Three untreated patients were studied with l-[methyl-11C]methionine. The tumour-imaging potential of l-[methyl-11C]methionine and l-[1-11C]tyrosine appeared to be nearly equivalent for prolactinomas. Unlike prolactinoma tissue, the salivary glands showed a pronounced preference for l-[1-11C]tyrosine as compared to l-[methyl-11C]methionine. l-[1-11C]tyrosine is a valuable tool to obtain information on the metabolism and treatment of prolactinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00181283
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  • 2
    Electronic Resource
    Electronic Resource
    Raman spectroscopic study of the effect of take-up speed on conformation, orientation, and crystallinity in PET fibers (1990)
    New York, NY : Wiley-Blackwell
    Polymers for Advanced Technologies 1 (1990), S. 133-142 
    Details
    ISSN: 1042-7147
    Keywords: Raman spectrum ; Crystallinity ; Conformation ; PET fibers ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The dependence of the Raman spectrum of PET fibers on take-up speed (TUS) during high-speed spinning is examined. It is found that conformational change, orientation, and crystallinity, all different functions of TUS as a processing variable, are reflected in the spectra. The data, as well as those from thermal annealing of PET fibers, are shown to be consistent with those from other techniques, leading to a set of equations from which a number of properties of the PET fibers can be determined from the Raman spectrum alone.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pat.1990.220010203
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  • 3
    Electronic Resource
    Electronic Resource
    A novel continuous centrifugal bioreactor for high-density cultivation of mammalian and microbial cells (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 38 (1991), S. 1190-1202 
    Details
    ISSN: 0006-3592
    Keywords: continuous centrifugal bioreactor ; ethanol fermentation ; mammalian cell hybridoma ; monoclonal antibody ; fluidized bed ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A continuous centrifugal bioreactor (CCBR), developed to study the growth and productivity of dense suspensions cultures, has been applied to both fermentation and mammalian cell cultivation processes. With this approach, high-density nonflocculent cultures are maintained in a tapered fluidized bed by balancing the drag forces on the cells due to following substrate with the centrifugal forces. The Sysyem was first used to produce ethanol by fermentation with Saccharomyces cerevisiae; then with H21A1 mouse hybridoma cells secreting monoclonal antibody (MoAb), lgM. Results of this research show the feasibility of using the CCBR for both production of secreted products and as a research tool for studying cell metabolism and production kinetics. Media recycle may be used to modify the behavior of the system form a plug flow apparatus to a continuous stirred reactor (CSTR).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260381011
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  • 4
    Electronic Resource
    Electronic Resource
    Antioxidant enzymes as biochemical defenses against phototoxin-induced oxidative stress in three species of herbivorous lepidoptera (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 16 (1991), S. 139-152 
    Details
    ISSN: 0739-4462
    Keywords: superoxide dismutase ; catalase ; glutathione peroxidase ; glutathione reductase ; hypericin ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Many secondary plant compounds are capable of photoactivation resulting in the production of toxic species of oxygen. One mechanism of defense for insects feeding on phototoxic plants may be the presence of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPOX), and glutathione reductase (GR). The activities of these enzymes were examined in larvae of three lepidoptera: Ostrinia nubilalis, Manduca sexta, and Anaitis plagiata. Highest levels of antioxidant enzyme activity were found in A. plagiata, a specialist feeder on Hypericum perforatum, which contains high levels of the phototoxin hypericin. Larvae of A. plagiata fed leaf discs treated with hypericin exhibited a short-term, concentration-dependent decline in enzyme activity. Longer term studies with A. palgiata fed either the photoxic H. perforatum, or the closely related but non-phototoxic H. calycinum, resulted in increased CAT and GR activity in larvae fed the phototoxic plant whereas SOD activity was not significantly different. These results suggest that CAT and GR may be inducible defenses against phototoxins.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940160206
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