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  • 1990-1994  (2)
  • Disperse systems  (1)
  • Minitracheotomy  (1)
  • 23.20.Ck
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 1447-1455 
    ISSN: 0392-6737
    Keywords: Disperse systems ; Molecular biophysics ; Physical chemistry of solutions of biological macromolecules ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary The aggregation behaviour of zinc-free insulin has been studied by small-angle neutron scattering as a function of protein concentration,pH, and ionic strength of the solution. The distance distribution functions for the 12 samples have been obtained by indirect Fourier transformation. The weight-averaged molecular mass and thez-averaged radius of gyration were determined. Both quantities vary systematically with the experimental conditions. They increase with decreasingpH and with increasing ionic strength. The radius of gyration scales as a power law of the weight-average mass with the exponent 0.44. A similar scaling is found for a set of oligomers structures based on the crystal structure of zinc-free insulin. The mass distribution between the oligomers was determined by a model based on these oligomers. The results from this model and the Fourier transformations have been compared to an equilibrium model recently introduced by Kadimaet al. The model takes into account the variation of the effective charge of the monomer withpH and ionic strength. The neutron scattering results agree well with the predictions of the model.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1238
    Keywords: Minitracheotomy ; Intensive care ; Indication ; Complication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with imminent respiratory failure due to sputum retention were assessed for minitracheotomy (MT). MT was considered potentially useful in 79 patients but only attempted in 73, 54 men and 19 women, aged 23–81 years (median 65 years). Insertion of the cannula failed in 4 cases. Sputum retention and atelectasis were successfully treated in 87% (N=60). Treatment by MT in medical and neurological patients seems as effective as in surgical patients (success rate 81% versus 90%). The frequency of complications was 16%. Most complications were insignificant and occurred during cannulation, but a few severe complications were seen. To minimize the number of these it is essential that MT is done only by doctors who are familiar with the procedure. MT can be recommended for treatment of sputum retention and atelectasis in surgical and medical/neurological intensive care patients with preserved cough function.
    Type of Medium: Electronic Resource
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