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Comparative study of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and tritiated thymidine in a chemosensitivity test using collagen gel matrix (1993)

Egawa, M. ; Hisazumi, H. ; Uchibayashi, T. ; [et al.]

Springer

Urological research 21 (1993), S. 83-88

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ISSN: 1434-0879

Keywords: Chemosensitivity test ; Collagen gel matrix ; 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ; Human transitional cell carcinoma

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary An organ culture system using collagen gel matrix (CGM) was modified and established successfully as a rapid and convenient method for determination of anti-cancer drug sensitivities. The cell viability of a tumor fragment was measured by the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) to a colored formazan product, which allowed for quantitative and simple analysis. The sensitivities of KK-47 bladder tumor from nude mice to various anti-cancer drugs tested corresponded closely to those determined in the originial CGM assay system using tritiated thymidine, which has a high clinical correlation. Our modified method can be used as a practical and highly reproducible chemosensitivity test in vitro.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01788824

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Stress-induced increase in noradrenaline release in the rat hypothalamus assessed by intracranial microdialysis (1990)

Yokoo, H. ; Tanaka, M. ; Tanaka, T. ; [et al.]

Springer

Cellular and molecular life sciences 46 (1990), S. 290-292

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ISSN: 1420-9071

Keywords: In vivo microdialysis ; stress ; noradrenaline release ; hypothalamus ; high performance liquid chromatography ; rat

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The hypothalamic microdialysis of conscious rats was used to investigate the effects of immobilization stress (20 min) on extracellular noradrenaline(NA) levels. The stress significantly increased NA levels relative to basal efflux by 106% and this elevation continued for 40 min after release from stress.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01951769

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L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, inhibits dopamine release and metabolism in the rat striatum in vivo (1992)

Mizoguchi, K. ; Tanaka, M. ; Yokoo, H. ; [et al.]

Springer

Cellular and molecular life sciences 48 (1992), S. 1133-1134

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ISSN: 1420-9071

Keywords: In vivo microdialysis ; striatum ; noradrenaline ; L-threo-3,4-dihydroxyphenylserine ; dopamine release ; 3,4-dihydroxyphenylacetic acid ; homovanillic acid ; high performance liquid chromatography

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract The effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on dopamine (DA) release and metabolism in the striatum was studied in freely moving rats by intracerebral microdialysis techniques. The DA level as well as the levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly decreased 140 min after the administration of L-threo-DOPS (50 mg/kg intraperitoneally). The results suggest that L-threo-DOPS inhibits the release and metabolism of DA in the striatum.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01948006

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