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  • 1990-1994  (3)
  • 5′ insulin gene polymorphism  (1)
  • Anti-nucleolar antibodies  (1)
  • Chemistry  (1)
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Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinophilia-myalgia syndrome (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 541-549 
    Details
    ISSN: 1432-1440
    Keywords: Eosinophilia myalgia syndrome ; Fibromyalgia syndrome ; Anti-serotonin antibodies ; Anti-ganglioside antibodies ; Anti-phospholipid antibodies ; Anti-nucleolar antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eosinophilia myalgia syndrome (EMS) has been related to intake of “contaminated” L-tryptophan, and an alteration in tryptophan 5-hydroxytryptamine (5-HT, serotonin) metabolism has been reported in EMS patients. Recently we found that a defined autoantibody pattern consisting of antibodies to nucleoli, gangliosides, and phospholipids is closely related to the fibromyalgia syndrome (FS) which clinically resembles the EMS. We were therefore interested to see whether these antibodies can also be detected in patients with EMS. Studied were 27 patients with acute EMS (13 of whom were also examined 2 years after acute onset), 100 patients with FS, and 40 patients with progressive systemic sclerosis (PSS). As controls, sera from 100 blood donors were analyzed. Antibodies to nucleoli were demonstrated by immunofluorescence test on cell cultures in 52% of patients with acute EMS, 62% of patients with chronic EMS, and 37% of FS patients. Western blotting with a nuclear extract from HeLa cells revealed in both diseases the same epitopes at 63, 57, and 53 kDa. Antibodies to 5-HT, gangliosides (Gm1), and phospholipids were determined by enzyme-linked immunosorbent assay. Among patients with FS 73% had antibodies to 5-HT, in contrast to only 19% of patients with acute EMS. However, 77% of the 13 EMS patients analyzed 2 years later had become anti-5-HT antibody positive during that time. Also the incidence of antibodies to Gm1 increased from 37% at acute onset to 69% in patients with chronic EMS (30%). The various antibodies were detected in only 18% of healthy controls. Serum 5-HT levels were decreased in patients with acute EMS compared to those with chronic EMS or FS. In patients with PSS they were significantly increased. It is concluded that EMS may have been developed in patients with FS who may have reacted in an allergic manner to a more immunogenic (“contaminated”) L-tryptophan.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00207485
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The 5′ insulin gene polymorphism and the genetics of vascular complications in Type 1 (insulin-dependent) diabetes mellitus (1991)
    Springer
    Diabetologia 34 (1991), S. 680-683 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; diabetic nephropathy ; 5′ insulin gene polymorphism ; heredity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent data suggest genetic contributions to the microvascular complications of Type 1 (insulin-dependent) diabetes mellitus. Most research has focused on the HLA region, and the potential role of other genetic loci has not been adequately explored. We examined the possible relationship between DNA polymorphisms in the region 5′ to the insulin gene on chromosome 11 and diabetic nephropathy. This was done by comparison of those diabetic patients homozygous for class 1 alleles at the 5′ insulin gene polymorphism locus to 1/3 heterozygotes in a well-characterized series of 324 insulin-requiring diabetic patients from the Wisconsin Epidemiologic Study of Diabetic Retinopathy. Proteinuria (defined as ≥0.3 g protein/l urine), was used as suggestive evidence for diabetic nephropathy. Hypertension, a frequent associated finding in diabetic patients with nephropathy, was defined as a blood pressure greater than 140/90 or a history of previous treatment of hypertension. The two genotypically defined groups did not differ from each other in regard to sex ratio, age at diagnosis, age at examination, duration of diabetes, body mass, HbAlc or C-peptide. The 1/1 group had a higher prevalence of proteinuria, 29% as compared to 16.2 % in other genotypes (p〈0.05). There was no significant difference in the frequency of hypertension between the two genotypic groups. This finding suggests that the 5′ insulin gene polymorphism may be associated with risk for nephropathy, but the pathophysiologic mechanism remains unclear.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400999
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Fatigue crack propagation behavior of ultra high molecular weight polyethylene under mixed mode conditions (1994)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 28 (1994), S. 181-187 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Analytical studies of the stresses on and within ultra high molecular weight polyethylene joint components suggest that damage modes associated with polyethylene fatigue failure are caused by a combination of surface and subsurface crack propagation. Fatigue crack propagation tests under mixed mode loading conditions were conducted on center-cracked tension specimens machined from extruded blocks of sterilized polyethylene in an attempt to determine how fatigue cracks change direction in this material. Cyclic testing was performed using a sinusoidal wave form at a frequency of 5 Hz and an R-ratio (minimum load/ maximum load) of 0.15. Specimens had the notch oriented perpendicular to the direction of applied load and at angles of 60° and 45° to the loading direction. Numerical analyses were used to interpret the experimental test and to predict the fatigue behavior of polyethylene under mixed mode conditions. It was found that all cracks eventually propagated horizontally, regardless of the initial angle of inclination of the notch to the direction of applied cyclic load. In fact, the extent of the curvilinear crack growth was quite limited. An effective range of cyclic stress intensity factor was calculated for correlation with the rate of crack growth. The results followed a Paris relation, with crack growth rate linearly related to a power of the range of stress intensity, for all three crack orientations. The numerical analyses adequately modeled the experimental fatigue crack growth results. © 1994 John Wiley & Sons, Inc.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820280207
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    Paper (German National Licenses)
    Fulltext
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