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  • 1990-1994  (3)
  • 75.40.Cx  (1)
  • Cilazapril  (1)
  • Mitochondrial swelling
  • 1
    Electronic Resource
    Electronic Resource
    Effects of angiotensin-converting enzyme inhibition on renal sodium handling after furosemide injection (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 622-627 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin-converting enzyme inhibitors ; Cilazapril ; Furosemide ; Natriuresis ; Antinatriuresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The goal of this study was to quantitate the effect of angiotensin-converting enzyme inhibition on renal sodium handling after furosemide injection. The study was carried out on low and normal salt intake to assess potential interaction with salt balance. Eighteen healthy normotensive volunteers were examined in a double placebo-controlled parallel group design. Subjects were randomly put on either low-salt (20 mmol/day) or normal-salt (110 mmol/day) diet. In either arm of the diet volunteers were first treated orally with placebo for 1 week and subsequently with 2.5 mg/day of the angiotensin-converting enzyme inhibitor cilazapril for another 1 week. Cumulative 24-h urinary sodium excretion was measured on the 6th day of the respective week after sham injection and on the 7th day after injection of 40 mg furosemide. Compared to pretreatment with placebo, pretreatment with cilazapril resulted in a higher cumulative sodium excretion after furosemide injection (day 7) than after the sham injection (day 6) on both salt intakes. The difference in natriuresis (cilazapril versus placebo) was evident 2 and 3 h after injection of furosemide. Neither the time of onset nor the magnitude of antinatriuresis were affected by cilazapril. Following furosemide angiotensin II increased significantly even after cilazapril pretreatment. Cilazapril tended to reduce urinary furosemide excretion. At any given urinary furosemide concentration, the increment in urinary sodium excretion was significantly greater with cilazapril irrespective of salt intake. The study shows that (a) cilazapril increases furosemide-induced natriuresis irrespective of salt intake, (b) antinatriuresis is not affected by cilazapril, and (c) angiotensin II levels rise after furosemide on cilazapril in therapeutic doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184489
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The surface to volume ratio of mitochondria, a suitable parameter for evaluating mitochondrial swelling (1990)
    Springer
    Virchows Archiv 416 (1990), S. 305-315 
    Details
    ISSN: 1432-2307
    Keywords: Myocardial ultrastructure ; Mitochondrial swelling ; Stereology ; Correlations of structural parameters ; Cardiac arrest and global ischaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cellular changes occuring in the left ventricular myocardium during ischaemia after different methods of cardiac arrest have been evaluated by morphological and morphometric parameters: volume densities of mitochondria (VVMi), sarcoplasm (VVSp), myofibrils (VVMf), surface densities of mitochondria (SVMi). The surface to volume ratio of mitochondria (SVratioMi) has been used as an independent parameter of mitochondrial swelling. Since ischaemic swelling of myocardial cells increases the volume of the reference space and ischaemic swelling of mitochondria decreases the free sarcoplasm, VVMi and VVSp cannot be considered as reliable indicators of the degree of oedema. SVMi/VVMf remains nearly constant after different forms of cardiac arrest, demonstrating the integrity of mitochondrial outer membranes. The inverse linear ratio between SVratioMi and the mean mitochondrial volume indicates that the increase in mitochondrial volume is achieved by surface smoothing. Loss of matrix structure and fragmentation of cristae occur at an SVratioMi of about 5.8, cristolysis at 5.5 to 5.6 and amorphous matrix densities at an SVratioMi of less than 5.5 μm2/μm3. The SVratioMi is a suitable parameter for evaluating mitochondrial swelling both at the onset and during global myocardial ischaemia, independent of the method of cardiac arrest used. It serves as an indicator of the state of structural preservation of mitochondria during ischaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605291
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Analysis of the ground-state wave function of theJ 1-J 2 quantum Heisenberg antiferromagnet (1993)
    Springer
    The European physical journal 93 (1993), S. 21-31 
    Details
    ISSN: 1434-6036
    Keywords: 75.10.Jm ; 75.40.Cx ; 75.50.Ee
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We investigate the ground-state wave function $$|\psi \rangle = \sum\limits_n {\alpha _n } |n\rangle $$ of the spin-1/2J 1-J 2 model on finite square lattices ofN=16(4×4) andN=24(4×6) sites. We find that the Marshall-Peierls phase rule for coefficientsα n , which was derived for unfrustrated bipartite lattices (J 2=0), holds exactly for comparably large frustration up toJ 2/J 1=0.28 (N=16) and up toJ 2/J 1=0.20 (N=24). But even for strong frustration up toJ 2/J 1≈0.45 the Marshall-Peierls rule describes the phase relationships in the ground state excellently. In the region of dominatingJ 2 a phase rule can be formulated as a product of the rules for two independent antiferromagnets. We find that the violation of the Marshall-Peierls sign rule does not dramatically affect the order parameters up toJ 2/J 1≈0.6. To calculate the magnitude of the coefficientsα n by a variational procedure we search for a represantative relationship between theα n and (a few) parametersP 1,n ...P k, n classifying the Ising basis states |n〉. By comparison with the exact ground state we analyze classification schemes based on pair correlations (Jastrow type wave functions) as well as schemes taking into account cluster parameters. While for small frustrationJ 2/J 1〈0.2 a short-range Jastrow description (nearest-neighbour and next nearestneighbour pairing) seems to be sufficient for the adequate description of the ground state one definitly needs longrange pairing and/or cluster parameters to construct a reasonable trial wave function for strong frustration. As an example for a special Jastrow type wave function we discuss an ansatz coming from the spin-wave theory. Finally, we consider the influence of the anisotropic exchangeJ zz ≠J xx ,J yy on the quality of the short-range Jastrow wave function and find and excellent agreement with the exact ground state already for Ising exchange anisotropiesJ xx =J yy ≈0.5J zz .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01308803
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    Paper (German National Licenses)
    Fulltext
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