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  • 1
    Electronic Resource
    Electronic Resource
    Failure of combination therapy with recombinant granulocyte colony-stimulating factor and erythropoietin in myelodyspplastic syndromes (1994)
    Springer
    Annals of hematology 68 (1994), S. 163-166 
    Details
    ISSN: 1432-0584
    Keywords: MDS ; Cytokine ; G-CSF ; EPO ; Combination therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recombinant human granulocyte colonystimulating factor (rhG-CSF) and erythropoietin (rhE-PO) were used to treat ten patients with myelodysplastic syndromes (MDS). None of the patients showed a favorable response in erythrocyte and platelet counts following 10 weeks' treatment, although favorable responses in neutrophil counts were observed in eight of ten patients (80.0%) and in seven of eight patients (87.5%) following 2 weeks' and 10 weeks' treatment, respectively. However, one patient with refractory anemia had a delayed favorable response in erythrocyte and neutrophil counts at week 14 in spite of the cessation of combination therapy at week 10. These results indicate that combination therapy with rhG-CSF and rhEPO is not beneficial to patients with MDS, based on the presently used protocol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834360
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative aspects of structure and action of molluscan neuropeptides (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 448-456 
    Details
    ISSN: 1420-9071
    Keywords: Neuropeptide ; Mollusca ; ABRM ; Mytilus ; Achatina ; Helix ; d-amino acid residue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A number of neuropeptides were isolated from the ganglia and muscles of molluscs, and their actions were examined. Diverse neuropeptides, in addition to several classical neurotransmitters, were suggested to be involved in the regulation of the anterior byssus retractor muscle ofMytilus. A wide structural variety of members of theMytilus inhibitory peptide family was observed in each of the generaMytilus, Achatina andHelix. Gly-Trp-NH2, the C-terminal dipeptide fragment of the neuropeptide AGPWamide, showed a more potent action than the parent peptide in all of the muscles examined. Peptides related to some molluscan neuropeptides were found to be distributed interphyletically. Some neuropeptides containing ad-amino acid residue were found inAchatina andMytilus. These aspects of molluscan neuropeptides are thought not to be exceptional.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928163
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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