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  • 1990-1994  (2)
  • Acetylcholine  (1)
  • Ca2+ channels  (1)
  • Welds  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Adrenergic and cholinergic inhibition of Ca2+ channels mediated by different GTP-binding proteins in rat sympathetic neurones (1991)
    Springer
    Pflügers Archiv 418 (1991), S. 592-600 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Ca2+ channels ; G protein ; Sympathetic ganglion ; Acetylcholine ; Noradrenaline ; Muscarinic receptors ; α-adrenergic receptors
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Effects of acetylcholine (ACh) and noradrenaline (NA) on voltage-gated ion channels of sympathetic neurones acutely dissociated from rat superior cervical ganglion (SCG) were examined using the whole-cell voltage-clamp technique. Depolarizing voltage steps elicited two types of low- and high-voltage-activated (LVA and HVA) Ca2+ currents. Pressure applications of ACh and NA produced concentration-dependent inhibition of the HVA Ca2+ current without affecting the LVA Ca2+ current. The inhibitory action of ACh on the Ca2+ current was blocked by a muscarinic antagonist, atropine. The action of NA was suppressed by an α 2-adrenergic antagonist, yohimbine, but not by an α 1-adrenergic antagonist, prazosin. Delayed rectifying outward K+ currents and inward rectifying K+ current were not affected by either ACh or NA. Tetrodotoxin-sensitive and -insensitive Na+ currents also remained unaffected under actions of ACh and NA. When recorded with electrode containing guanosine-5′-O-(3-thiotriphosphate) (GTP-γ-S), the inhibitory actions of ACh and NA on Ca2+ currents became irreversible. After treatment of SCG neurones with pertussis toxin, the inhibitory action of ACh on the Ca2+ current was almost completely abolished, whereas the action of NA was only partially reduced. The results suggest that ACh and NA differentially inhibit the HVA Ca2+ current via different G proteins coupling muscarinic and α 2-adrenergic receptors to Ca2+ channels in rat SCG neurones.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00370576
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Ultrasonic flaw classification in weldments using probabilistic neural networks (1992)
    Springer
    Journal of nondestructive evaluation 11 (1992), S. 69-77 
    Details
    ISSN: 1573-4862
    Schlagwort(e): Welds ; flaw classification ; ultrasonics ; neural networks
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik , Mathematik
    Notizen: Abstract A probabilistic neural network is used here to classify flaws in weldments from their ultrasonic scattering signatures. It is shown that such a network is both simple to construct and fast to train. Probabilistic nets are also shown to be able to exhibit the high performance of other neural networks, such as feed forward nets trained via back-propagation, while possessing important advantages of speed, explicitness of their architecture, and physical meaning of their outputs. Probabilistic nets are also demonstrated to have performance equal to common statistical approaches, such as theK-nearest neighbor method, while retaining their unique advantages.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00568290
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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