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  • 1990-1994  (3)
  • Active N pool  (1)
  • Cilazapril  (1)
  • Mitochondrial swelling
  • 1
    ISSN: 1432-2307
    Keywords: Myocardial ultrastructure ; Mitochondrial swelling ; Stereology ; Correlations of structural parameters ; Cardiac arrest and global ischaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cellular changes occuring in the left ventricular myocardium during ischaemia after different methods of cardiac arrest have been evaluated by morphological and morphometric parameters: volume densities of mitochondria (VVMi), sarcoplasm (VVSp), myofibrils (VVMf), surface densities of mitochondria (SVMi). The surface to volume ratio of mitochondria (SVratioMi) has been used as an independent parameter of mitochondrial swelling. Since ischaemic swelling of myocardial cells increases the volume of the reference space and ischaemic swelling of mitochondria decreases the free sarcoplasm, VVMi and VVSp cannot be considered as reliable indicators of the degree of oedema. SVMi/VVMf remains nearly constant after different forms of cardiac arrest, demonstrating the integrity of mitochondrial outer membranes. The inverse linear ratio between SVratioMi and the mean mitochondrial volume indicates that the increase in mitochondrial volume is achieved by surface smoothing. Loss of matrix structure and fragmentation of cristae occur at an SVratioMi of about 5.8, cristolysis at 5.5 to 5.6 and amorphous matrix densities at an SVratioMi of less than 5.5 μm2/μm3. The SVratioMi is a suitable parameter for evaluating mitochondrial swelling both at the onset and during global myocardial ischaemia, independent of the method of cardiac arrest used. It serves as an indicator of the state of structural preservation of mitochondria during ischaemia.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Angiotensin-converting enzyme inhibitors ; Cilazapril ; Furosemide ; Natriuresis ; Antinatriuresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The goal of this study was to quantitate the effect of angiotensin-converting enzyme inhibition on renal sodium handling after furosemide injection. The study was carried out on low and normal salt intake to assess potential interaction with salt balance. Eighteen healthy normotensive volunteers were examined in a double placebo-controlled parallel group design. Subjects were randomly put on either low-salt (20 mmol/day) or normal-salt (110 mmol/day) diet. In either arm of the diet volunteers were first treated orally with placebo for 1 week and subsequently with 2.5 mg/day of the angiotensin-converting enzyme inhibitor cilazapril for another 1 week. Cumulative 24-h urinary sodium excretion was measured on the 6th day of the respective week after sham injection and on the 7th day after injection of 40 mg furosemide. Compared to pretreatment with placebo, pretreatment with cilazapril resulted in a higher cumulative sodium excretion after furosemide injection (day 7) than after the sham injection (day 6) on both salt intakes. The difference in natriuresis (cilazapril versus placebo) was evident 2 and 3 h after injection of furosemide. Neither the time of onset nor the magnitude of antinatriuresis were affected by cilazapril. Following furosemide angiotensin II increased significantly even after cilazapril pretreatment. Cilazapril tended to reduce urinary furosemide excretion. At any given urinary furosemide concentration, the increment in urinary sodium excretion was significantly greater with cilazapril irrespective of salt intake. The study shows that (a) cilazapril increases furosemide-induced natriuresis irrespective of salt intake, (b) antinatriuresis is not affected by cilazapril, and (c) angiotensin II levels rise after furosemide on cilazapril in therapeutic doses.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Biology and fertility of soils 16 (1993), S. 45-51 
    ISSN: 1432-0789
    Keywords: Deep tillage ; N balance calculations ; N immobilization ; N mineralization potential ; Organic matter equilibria ; Active N pool ; Stable N pool
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The depth of ploughing has increased in West Germany during the last three decades. Before the 1960s, the depth of the Ap horizon rarely exceeded 25 cm; in the early 1980s it reached about 35 cm on average but it has remained constant since that time. In 1989, the total N content of 105 plots in the southern Niedersachsen loess area was measured after deepening of the plough layers. The N content of the samples was compared with that of earlier samplings (1) before deeper tillage in the 1960s, the 1970s, and the 1980s; and (2) in 1983. Directly after the deeper ploughing, the N content of the topsoil decreased, presumably due to dilution with the subsoil material. Mass balance calculations for total N in 1989 showed that the phase of N accumulation can take 20 years or more. Within two decades, up to 2000 kg N ha-1 was immobilized in the soil organic matter. Recent incubation experiments with disturbed soil indicated that the N mineralization capacity was reestablished in all soils and is now similar to that of the early (1960s and 1970s) and more recent (1980s) deepened plough layers. Undisturbed soil material incubated in plastic tubes showed a significantly reduced net mineralization at water contents above 65% of the waterholding capacity, particularly in the lower part (15–30 cm) of the Ap horizon. This study suggests that N accumulated in the deep plough layers cannot contribute noticeably to net N mineralization in loess soils during the growing season.
    Type of Medium: Electronic Resource
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