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  • 1990-1994  (2)
  • Basedow's disease  (1)
  • Multivariate analysis  (1)
  • Key words Skin cancer
  • 1
    Electronic Resource
    Electronic Resource
    Distribution of S-100 protein-positive dendritic cells and expression of HLA-DR antigen in transitional cell carcinoma of the urinary bladder in relation to tumour progression and prognosis (1993)
    Springer
    Virchows Archiv 422 (1993), S. 351-355 
    Details
    ISSN: 1432-2307
    Keywords: Bladder cancer ; S-100 protein ; HLA-DR/dendritic cell ; Multivariate analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution of S-100 protein positive dendritic cells (S100-DCs) in cancer nests and the expression of HLA-DR antigen on cancer cells in 90 patients with transitional cell carcinoma of the urinary bladder were studied immunohistochemically. A dense infiltrate of S100-DCs (more than 10 S100-DCs/high power field) was detected in 47 out of 90 cases, while in the remaining tumours the infiltrate was sparse. HLA-DR positive cancer cells (DR-CCs) were detected in 24 cases, including 16 with dense DR-CCs (more than 100 DR-CCs/high power field); no expression was observed in the remaining tumours. In terms of the numbers of S100-DCs infiltrating the following statistically significant differences were observed: tumour grading G1〉G3, depth of penetration pT0〉pT3; (p〈0.05), G2〉G3, lymphatic invasion-〉+ and venous invasion -〉+; (p〈0.01). A multivariate analysis demonstrated that the most important factor affecting prognosis was distant organ and/or lymph node metastasis (p〈0.01) the number of S100DCs, with a hazard ratio (HR) of 0.26 (p〈0.01), and the number of DR-CCs with HR of 0.18 (p〈0.05); these were statistically significant. S100-DCs and DR-CCs may be regarded as independent prognostic factors of tumour growth and progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01605452
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Immunohistochemical and ultrastructural studies of thyroid tissue from a patient with Basedow's disease and immunopositive for human T-lymphotropic virus type I (HTLV-I) (1994)
    Springer
    Medical molecular morphology 27 (1994), S. 136-144 
    Details
    ISSN: 1860-1499
    Keywords: Human T-lymphotropic virus type I (HTLV-I) ; Ultrastructure ; Basedow's disease ; Lymphocyte ; Thyroid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Thyroid tissue from a patient with Basedow's disease and immunopositive for HTLV-I was examined. Histopathological and immunohistochemical studies revealed that follicular-epithelial cells (FEC) had papillary projections reaching into the follicular lumina which were associated with diffuse T, but not B, lymphocyte infiltration and occasionally formed aggregations intermingled with T and B lymphocytes. Ultrastructurally, infiltrated lymphocytes possessing round or irregularly indented nuclei were detected in the capillary lumen, stroma and, also, FEC layers. The lymphocytes extended irregular processes, attached to long thin processes of FEC and infiltrated into FEC layers. Cocultivation of minced thyroid tissue with normal lymphocytes resulted in the establishment of a type-C virus-producing T-cell line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348178
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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