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Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescencein situ hybridization (1992)

Inoue, Kiyoshi ; Inazawa, Johji ; Nakagawa, Hitoshi ; [et al.]

Springer

Journal of human genetics 37 (1992), S. 133-138

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ISSN: 1435-232X

Keywords: fluorescencein situ hybridization ; CYP3A4 ; chromosomal mapping ; chromosome 7

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary We have used a full length cDNA clone (2.2 kb) for the human cytochrome P-450 nifedipine oxidase (CYP3A4) enzyme as a probe to determine its chromosome localization by fluorescencein situ hybridization. CYP3A4 was mapped on R-banded human prometaphase chromosomes, and the precise localization of CYP3A4 on chromosome 7 was further confirmed by a delineation of G-banded pattern on the same prometaphase chromosomes through a combination of UV-filter. We assigned CYP3A4 to chromosome 7 at q22.1.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01899734

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Fluorescencein situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1 (1994)

Inoue, Kiyoshi ; Inazawa, Johji ; Suzuki, Yasuhiko ; [et al.]

Springer

Journal of human genetics 39 (1994), S. 337-343

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ISSN: 1435-232X

Keywords: fluorescencein situ hybridization ; CYP2C subfamily ; chromosome 10 ; chromosomal localization ; polymerase chain reaction

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Chromosomal localization of three human cytochrome P450 genes belonging to the CYP2C subfamily (CYP2C8, 2C9, and 2C10) was identified by fluorescencein situ hybridization (FISH). An original MP-8 clone was used as a DNA probe for the assignment of the CYP2C10 gene, while two cDNA probes, a 1.37 kb fragment of CYP2C8 and a 1.19 kb fragment (MP-20 and MP-4 clones, respectively) by polymerase chain reaction using a single human liver cDNA library. The results showed that three human CYP2C8, 2C9, and 2C10 cDNAs were located at the same subchromosomal region, 10q24.1.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01874052

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