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  • 1990-1994  (2)
  • Catalepsy  (1)
  • Genetically selected rat lines  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Naloxone-induced analgesia and morphine supersensitivity effects are contingent upon prior exposure to analgesic testing (1990)
    Springer
    Psychopharmacology 101 (1990), S. 31-35 
    Details
    ISSN: 1432-2072
    Keywords: Analgesia ; Catalepsy ; Contingency ; Morphine ; Naloxone ; Naloxone-induced analgesia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Repeated administration of naloxone have been found to result in the development of analgesia. Pretreatment with naloxone can also produce supersensitivity to morphine. This study examined whether the development of these phenomena is affected by exposure to pain (hotplate testing) during opiate blockade. During acquisition, two experimental groups of rats received identical treatment with respect to repeated naloxone injections (5 mg/kg) and the environment in which the injections were administered. A “contingent” group (NAL-C) received hot-plate testing under the influence of naloxone, while a “noncontingent” group (NAL-NC) experienced hot-plate testing and naloxone separated by an interval of 24 h. At test, NAL-C rats manifested naloxone-induced analgesia (NIA) whereas the NAL-NC animals did not. The NAL-C rats also showed supersensitivity to the analgesic effects of morphine (3 mg/kg) and to the cataleptic effects of morphine (17.5 mg/kg) while the NAL-NC rats did not differ from saline controls. Thus, both NIA and morphine supersensitivity were completely dependent on testing in the drug state during acquisition; mere exposure to an identical regime of naloxone injections was insufficient to produce these phenomena.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245785
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Role of initial sensitivity and genetic factors in the development of tolerance to ethanol in AT and ANT rats (1990)
    Springer
    Psychopharmacology 102 (1990), S. 11-16 
    Details
    ISSN: 1432-2072
    Keywords: Genetically selected rat lines ; Ethanol ; Tolerance ; Initial sensitivity ; Genetic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The role of initial sensitivity and genetic factors in the development of tolerance to ethanol were examined in rats selected for low (AT) and high (ANT) sensitivity to the motor impairment effect of ethanol. Following chronic ethanol treatment (5 g/kg PO, daily for 20 days), the AT and ANT rats acquired tolerance to the motor impairment effect of ethanol at a similar rate. The AT rats, however, acquired tolerance to the hypothermic effect of ethanol at a higher rate than the ANT rats. Such ethanol treatment did not produce any metabolic tolerance to ethanol in these animals. Since there is no difference in the initial response to the hypothermic effect of ethanol between the AT and ANT rats, the observed differences in the rate of tolerance development might be related to a direct genetic factor. The similar rate of tolerance development to the motor impairment effect of ethanol between the two lines was attributed to an interaction between an indirect (initial sensitivity) and a genetic factor in tolerance development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245737
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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