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Triiodothyronine level and triiodothyronine/thyroxine ratio in HBeAg-positive chronic hepatitis patients treated with prednisolone withdrawal (1990)

Itoh, S. ; Matsuo, S. ; Oda, T. ; [et al.]

Springer

Digestive diseases and sciences 35 (1990), S. 1110-1114

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ISSN: 1573-2568

Keywords: thyroid hormones ; HBeAg-positive chronic active hepatitis ; prednisolone withdrawal ; alanine aminotransf erase ; HBV-DNA polymerase

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Twenty patients with hepatitis B e antigen (HBeAg) -positive chronic hepatitis, who received 40 mg of prednisolone per day for three weeks followed by withdrawal, were studied for changes in alanine aminotransferase (ALT), triiodothyronine (T3), thyroxine (T4), and hepatitis B virus DNA polymerase (HBV-DNAp) levels determined before and during prednisolone treatment and after its withdrawal. A decreased HBV-DNAp level of less than 100 cpm/ml three to five weeks after withdrawal was considered a sign of efficacy and was shown in 10 patients (50%). Significant differences were found between ALT levels, between T3 levels, and between the T3/T4 ratios assayed in the third and fourth weeks in total (P〈0.02) and in the group in which efficacy was demonstrated (P〈0.01). The T3/T4 ratio in the third week in the effectively treated group was significantly less than that in the noneffectively treated group (P〈0.05). Prednisolone withdrawal effective for HBV-DNAp was shown in the patients with a decreased T3 level and the T3/T4 ratio at the third week and an increase in the ALT level after the withdrawal. The ALT level increased after the T3 level decreased. Changes in the T3 level or the T3/T4 ratio represent a marker for effectiveness of prednisolone withdrawal and for determination of combination therapy after steroid withdrawal.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01537583

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Acyloin condensation in aqueous system by durable polymer-supported thiazolium salt catalysts (1994)

Yamashita, K. ; Osaki, T. ; Sasaki, K. ; [et al.]

Bognor Regis [u.a.] : Wiley-Blackwell

Journal of Polymer Science Part A: Polymer Chemistry 32 (1994), S. 1711-1717

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ISSN: 0887-624X

Keywords: durable catalyst ; thiazolium salt ; aqueous system ; acyloin condensation ; enzyme model ; Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: We characterized three low-molecular-weight thiazolium salt analogues: N-methyl-5-(2′-benzyloxyethyl)-4-methylthiazolium iodide (MBMTI), N-methyl-4-phenylthiazolium iodide (MPTI), and N-methylbenzothiazolium iodide (MBTI). MBMTI, having high-electron density on the thiezolium ring, was found to be a durable thiazolium salt in buffer solution. Then, the polymer-supported thiazolium salt catalyst having MBMTI structure as a catalytic site for acyloin condensation was prepared by the polymerization of the corresponding thiazole monomer and the following quaternization. The polymer catalyst had excellent catalytic activity even in buffer solution, while the corresponding low molecular weight catalyst did not show any activity in aqueous system. Furthermore, the durable polymer catalyst could be reused under the aqueous condition. © 1994 John Wiley & Sons, Inc.

Additional Material: 1 Ill.