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  • 1
    Electronic Resource
    Electronic Resource
    Variation of benzbromarone elimination in man — a population study (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 173-176 
    Details
    ISSN: 1432-1041
    Keywords: Benzbromarone ; elimination ; phenotype distribution ; drug metabolism ; drug polymorphism ; adverse reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The plasma benzbromarone concentration-time profile in a healthy subject who retained the compound much longer than other individuals is described. The data suggested that determination of the 24 h plasma concentration of the parent drug after a single oral dose of 100 mg benzbromarone would be an appropriate procedure to determine the elimination phenotype. Based on this procedure, 148 of 153 healthy individuals (97%) in a population study were found to eliminate benzbromarone rapidly. In one subject the 24 h benzbromarone plasma concentration was very similar to the that observed in the individual who had been more fully characterized. Four participants gave intermediate results. The data are compatible with a bimodal or trimodal distribution of different benzbromarone elimination phenotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280054
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Neue makrocyclische Wirte für den Einschluß von organischen Gastmolekülen - Kristallstruktur eines Komplexes mit Dimethylformamid (1 : 1) (1993)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 335 (1993), S. 235-243 
    Details
    ISSN: 0941-1216
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: New Macrocyclic Hosts for the Inclusion of Organic Guest Molecules - Crystal Structure of a Complex with Dimethylformamide (1 : 1)New pyridino crowns with amide and sulfonamide groups 1b and 1c are synthesized. They form numerous stoichiometric crystalline inclusion complexes with alcohols, various dipolar-aprotic solvents, as well as cyclic ethers. Host-guest stoichiometries are discussed and inclusion selectivities (relating to DMF) are shown. The structure of the crystalline DMF inclusion compound of the sulfonamide host 1c (1 : 1) is determined by X-ray diffraction, showing a lattice void inclusion mode.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.19933350305
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Improvement of the AES detection limit for phosphorus in silicon by principal component analysis or spline smoothing (1990)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 15 (1990), S. 583-584 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The detection limit of Auger electron spectroscopy (AES) can be improved by mathematical methods that reduce the influence of noise. We compared principal component analysis (PCA) and spline smoothing and applied them to the analysis of a phosphorus depth profile in silicon. Both methods yield similar results under typical conditions, namely detection limits of ∼0.04 at.% P compared with a limit of 0.09 at.% for the raw data. At a reduce signal-to-noise ratio, the PCA failed and the improvement by smoothing remained constant.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/sia.740150912
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    Paper (German National Licenses)
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