Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1962)
    Springer
    Journal of molecular medicine 40 (1962), S. 857-861 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01492723
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Zur Beeinflussung der Purin- und Pyrimidinsynthese durch Allopurinol (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 255-260 
    Details
    ISSN: 1432-1440
    Keywords: Purine metabolism ; pyrimidine metabolism ; orotic acid ; allopurinol ; Purinstoffwechsel ; Pyrimidinstoffwechsel ; Orotsäure ; Allopurinol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Allopurinol führt durch Hemmung der Xanthinoxydase zu einem Abfall der Serumharnsäure und der renalen Harnsäureausscheidung bei gleichzeitigem Anstieg der Ausscheidung von Hypoxanthin und Xanthin im Urin. Der Anstieg der Oxypurinelimination ersetzt jedoch bei den meisten Patienten nicht die Abnahme der renalen Harnsäureausscheidung. Dies wird auf eine zusätzliche Hemmung der Purinsynthese de novo zurückgeführt. Eine unterschiedliche Beeinflussung der endogenen und exogenen Uratquote durch Allopurinol bietet eine alternative Erklärung des Purindefizites. Die Beeinflussung des Pyrimidinstoffwechsels beruht auf einer Hemmung des Enzyms Orotidyldecarboxylase durch die Ribonucleotide von Allopurinol, Xanthin und Oxipurinol. Sie geht mit einer vermehrten Ausscheidung von Orotsäure und Orotidin im Urin einher. Die zusätzliche Gabe von Ribonucleinsäure führt zu einer deutlichen Abnahme der durch Allopurinol hervorgerufenen Orotacidurie. Der Hemmung der Orotidyldecarboxylase folgt unter kontinuierlicher Allopurinolverabreichung ein Anstieg der Aktivität von Orotatphosphoribosyltransferase und Orotidyldecarboxylase, dessen Mechanismus noch nicht vollständig geklärt ist. Allopurinol wird rasch metabolisiert. Nur 3–10% werden unverändert im Urin ausgeschieden. Hauptmetabolit ist Oxipurinol. Ein kleiner Anteil wird zu den Ribonucleosiden und Ribonucleotiden1 von Allopurinol und Oxipurinol umgewandelt.
    Notes: Summary Allopurinol inhibits xanthinoxydase. This results in a decrease of the serum and urinary uric acid: Simultaneously the renal excretion of hypoxanthine and xanthine increases. In most patients, however, the decrease of urinary uric acid is not completely replaced by the increase of oxypurines. This is attributed to an additional inhibition of de novo purine biosynthesis. The different effect of allopurinol on the endogenous and exogenous urates offers an alternative approach to explain the “purine deficit”. The effect of allopurinol on the pyrimidine metabolism is due to an inhibition of orotidylic decarboxylase by the ribonucleotides of allopurinol, xanthine and oxipurinol. This inhibition is followed by an increase in the urinary excretion of orotidine and orotic acid. The additional administration of ribonucleic acid leads to a striking decrease of the allopurinol induced orotaciduria. The continuous administration of allopurinol also produces an increase in the activity of orotate phosphoribosyltransferase and orotidylic decarboxylase. At this time the mechanism of this increase in activity is not completely understood. Allopurinol is metabolized rapidly. Only 3–10% of an administered dose are excreted unchanged in the urine. Most of the allopurinol is oxidized to oxipurinol. A small portion is converted to the ribonucleosides and ribonuclcotides of allopurinol and oxipurinol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469116
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 349-352 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469065
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Extracardiale Atherosklerose bei Patienten mit familiärer Hypercholesterinämie (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1123-1130 
    Details
    ISSN: 1432-1440
    Keywords: FHC ; Coronary atherosclerosis ; Non-cardiac atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 64 patients with familial hypercholesterolemia (FHC) confirmed by tissue culture of skin fibroblasts (3 homozygotes, 9 heterozygotes) 12 (3 homozygotes, 9 heterozygotes) had signs of atherosclerosis of the carotid arteries and of the peripheral arteries (extracardiac vasculature). 8 heterozygotes as well as the three homozygotes had coronary atherosclerosis. Three of the 12 patients with carotid artery disease suffered from clinical symptoms of cerebrovascular insufficiency. Only five patients with heterozygous FHC had symptomatic peripheral artery disease though 10 including the three homozygotes had signs of atherosclerosis of the abdominal aorta and its peripheral branches. It is concluded that patients with FHC develop generalized atherosclerosis but not always symptoms of peripheral artery disease. Risk factors other than hypercholesterolemia do not seem to contribute essentially to the development of atherosclerosis. It seems important to evaluate patients with FHC regularly for atherosclerosis of the carotid arteries which might be recognized earlier than coronary atherosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01530839
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 839-839 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727481
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Die Wirkungen gleicher Mengen Linolsäure in oral zugeführten, mehrfach ungesättigten Phospholipiden oder in Safloröl auf die Lipoproteine des Plasmas (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 980-984 
    Details
    ISSN: 1432-1440
    Keywords: Polyenylphosphatidylcholine ; Safloroil ; Plasma Lipoproteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of polyenylphosphatidylcholine in a dosage of 10 g per day were compared with an equimolar amount of linoleic acid in 7 g safloroil per day in 8 healthy subjects for 3 weeks. The concentrations of cholesterol, triglycerides, phospholipids, apolipoproteins A-I, A-II and B were measured in serum, as well in VLDL, LDL, HDL, HDL2, HDL3 on the day before, after 2 and 3 weeks of application and 6 months after the experiment. The diet was controlled 10 days before and during the experiment using the dietary recall method. According to the dietary records there was an increase of fat supply during application of polyenylphosphatidylcholine inhibiting decrease of LDL cholesterol, which was observed with safloroil. Phospholipid concentrations increased significantly with polyenylphosphatidylcholine in VLDL. Apolipoprotein B in LDL was significantly decreased by both substances. Apolipoprotein A-I and A-II in HDL increased significantly with polyenylphosphatidylcholine. With safloroil this effect was limited to apolipoprotein A-I, but less impressive. The effects of both substances are comparable in the decrease of apolipoprotein B and probably cholesterol. A special effect of polyenylphosphatidylcholine was observed on phospholipids in VLDL and on apolipoprotein A-I and A-II in HDL.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01717833
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Die Phosphatide in Serum und Leber bei Lebercirrhose (1971)
    Springer
    Journal of molecular medicine 49 (1971), S. 199-205 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Phosphatide des Serums von Gesunden (n=30) und Patienten mit Hepatitis (n=2) und Lebercirrhose (n=12) wurden dünnschichtchromatographisch getrennt und quantitativ bestimmt. Die Gesamtphosphatide des Serums waren bei Hepatitis erhöht, bei Lebercirrhose ließ sich der Durchschnittswert vom Vergleichskollektiv nicht unterscheiden, die Standardabweichung war jedoch mehr als doppelt so groß. Lecithin war mit einer Ausnahme bei allen Patienten erhöht, Lysolecithin umgekehrt proportional zum direkten Bilirubin erniedrigt, Sphingomyelin nur gering vermindert. Die Phosphatidfettsäuren wurden im Serum von Gesunden (n=10) und Patienten mit Lebercirrhose (n=10), Cholangitis (n=2), chronischer Hepatitis (n=2) und Verschlußikterus (n=2) gaschromatographisch untersucht. Ölsäure und Palmitinsäure waren bei Lebercirrhose erhöht, die Linolsäure erniedrigt. Bei den anderen Leberkrankheiten wurden ähnliche, wenn auch nicht so ausgeprägte Befunde erhoben. In cirrhotischem Lebergewebe (n=2) war der Absolutgehalt an Lecithin unverändert, Kephaline stark vermindert, Lysolecithin und Sphingomyelin auf Kosten des Kephalin erhöht. Die Phosphatidfettsäuren zeigten eine Vermehrung der Palmitin- und Ölsäure und eine Verminderung der C18:2 und C20:4 Fettsäuren. In Lebercarcinomgewebe (n=1) war gegenüber der cirrhotischen Restleber der Gehalt an C18:2 unverändert, an C20:4 dagegen vermindert, an C16:1 und C18:1 vermehrt.
    Notes: Summary The serum phospholipids of healthy subjects (n=30) and of patients with hepatitis (n=2) and liver cirrhosis (n=12) were separated by thin layer chromatography. The fractions were determined quantitatively. Increased phospholipid levels were found in hepatitis. The average phospholipid levels in patients with liver cirrhosis were the same as in the normal subjects, but the standard deviation from the mean was twice that of the normals. Lecithin had increased in all but one patient; lysolecithin was inversely related to the direct serum bilirubin concentrations, sphingomyelin was only slightly decreased. The fatty acids of phospholipids in serum of healthy subjects (n=10), patients with liver cirrhosis (n=10), cholangitis (n=2), chronic hepatitis (n=2) and obstructive jaundice (n=2) were analysed by gaschromatography. In cirrhosis, oleic acid and palmitic acid were increased, linoleic acid decreased. Similar but not as marked results were obtained in patients suffering from other hepatic diseases. In cirrhotic liver tissue (n=2) the concentration of lecithin tended to be normal, the concentration of cephalin was lowered, those of lysolecithin and sphingomyelin were elevated. Increased palmitic and oleic acid levels and decreased C18:2 and C20:4 fatty acid levels were observed. In cancerous tissue of the liver (n=1) the content of C18:2 fatty acids was unchanged. The percentage of C20:4 fatty acids however was lowered, those of C16:1 and C18:1 fatty acids were elevated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01495982
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Fatal lymphoproliferation and acute monocytic leukemia-like disease following infectious mononucleosis in the elderly (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 477-483 
    Details
    ISSN: 1432-1440
    Keywords: Infectious mononucleosis ; EB virus infection ; Acute monocytic leukemia ; Fatal lymphoproliferation ; Infektiöse Mononukleose ; EB-Virus-Infektion ; akute Monozytenleukämie ; Lymphoproliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über drei ältere Patienten berichtet, bei denen auf serologisch gesicherte, frische infektiöse Mononukleose eine tödlich verlaufende lymphoproliferative Erkrankung (Fall 1), eine akute Leukämie vom monozytären Differenzierungstyp (Fall 2) und eine akute Leukämie von wahrscheinlich monozytärem Differenzierungstyp (Fall 3) folgt.
    Notes: Summary Three elderly patients are reported, in whom serologically confirmed recent infectious mononucleosis is followed by fatal lymphoproliferation (case 1), by acute monocytic leukemia (case 2), and by acute probably monocytic leukemia (case 3).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696209
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Störungen des Lipoprotein- und Fettsäurenstoffwechsels bei Schwerverletzten (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 1327-1337 
    Details
    ISSN: 1432-1440
    Keywords: Patients with heavy injuries ; Plasma lipoproteins ; Essential fatty acids ; Parenteral nutrition ; Schwerverletzte ; Plasmalipoproteine ; Essentielle Fettsäuren ; Parenterale Ernährung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Patienten mit schweren Verletzungen nach einem Unfall leiden unter schwerwiegenden Störungen des Hormonhaushalts und des Stoffwechsels. Um die Ursache dieser Veränderungen und den Mechanismus des Fetttransports im Plasma in dieser kritischen Situation zu studieren, wurden die Lipoproteine und die Fetsäureverteilung im Plasma bei vier Patienten nach einem schweren Unfall und während der Rekonvaleszenz bis zu 30 Tage lang fortlaufend kontrolliert. Bei allen Patienten ist das Gesamt-Cholesterin im Plasma unter 100 mg/100 ml abgesunken, vorweigend durch einen Abfall des LDL-Cholesterins. Das HDL-Cholesterin ist aber auch vermindert. Die Triglyceridspiegel sind zunächst sehr niedrig, und der nachfolgende Anstieg ist auf eine Zunahme der VLDL-Triglyceride wie auch der LDL-Triglyceride zurückzuführen. So ergibt sich eine umgekehrte Korrelation zwischen HDL-Cholesterin und VLDL- sowie LDL-Triglyceriden. In den HDL fällt der Quotient aus Cholesterin und Phosphatiden von 1,4 auf 0,2 ab und zeigt damit deutliche Veränderungen in der Zusammensetzung dieser Lipoproteinfraktion an. Apolipoprotein B und der Proteinanteil der Lipoproteinfraktionen sind nach dem Unfall ebenfalls erniedrigt. Innerhalb 3–5 Tagen sind die Linolsäurespiegel in allen Lipiden der Lipoproteinfraktionen des Plasmas erniedrigt, am deutlichsten in den Cholesterinestern. Arachidonsäure ist nur bei zwei Patienten in den Phosphatiden erniedrigt. Als Parameter eines Mangels an essentiellen Fettsäuren in Geweben steigt die Eicosatriensäure (C20:ω9) in den Phosphatiden des Plasmas an. Die vollständige parenterale Ernährung mit Fettemulsionen führt zu guten Ergebnissen bei der Normalisierung der Plasmalipoproteine und der Verteilung der Fettsäuren und beeinflußt die Zusammensetzung von VLDL, LDL und HDL. Um die Spiegel von Linolsäure und Arachidonsäure in Plasmalipiden zu normalisieren, ist eine Zufuhr von bis zu 56 g Linolsäure pro Tag notwendig. Nach Abklingen der akuten Reaktionen von Kreislauf und Stoffwechsel können bei der kompletten parenteralen Ernährung von Schwerverletzten Fettemulsionen bis zu einer Menge von 30%–40% des Energiebedarfs verwendet werden.
    Notes: Summary Critically ill patients after a heavy accident suffer from major disturbances of hormones and metabolism. To study the origin of these alterations and the mechanisms of lipid transport through plasma in this critical situation plasma lipoproteins and fatty acid distribution were analyzed consecutively in four patients after a heavy accident and during convalescence up to 30 days. In all patients whole plasma cholesterol is reduced below 100 mg/dl, predominantly by a decrease of LDL-cholesterol, but HDL-cholesterol is also reduced. Triglycerides start with very low levels and the following increase of whole plasma triglycerides is due to increasing amounts of VLDL-triglycerides. Thus, a negative relationship between HDL-cholesterol and VLDL- as well as LDL-triglycerides was found. In HDL the ratio of cholesterol to phospholipids changes from 1.4 to 0.2, indicating major alternations in the composition of this lipoprotein fraction. Apolipoprotein B and total protein in lipoprotein fractions are also decreased by injury. Within 3–5 days linoleic acid levels are decreased in all lipid and lipoprotein fractions of plasma, but most pronounced in cholesterol esters. Arachidonic acid is only decreased in two patients in the phospholipid fraction. As parameter of essential fatty acid deficiency in tissues eicosatrienoic acid (C20:3ω9) increases in phospholipids of plasma. Total parenteral nutrition with fat emulsions obtains good results in the normalization of plasma lipoproteins and fatty acid distribution by influencing the composition of VLDL, LDL, and HDL. A supply of up to 56 g linoleic acid per day is necessary to normalize linoleic acid and arachidonic acid levels in plasma lipids. After cessation of the acute reactions of circulation and metabolism fat emulsions can be used in total parenteral nutrition of patients after injury in an amount of 30–40% of energy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477730
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Der Einfluß von Nahrungspurinen und -pyrimidinen auf die Pyrimidinsynthese des Menschen (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1191-1197 
    Details
    ISSN: 1432-1440
    Keywords: Pyrimidine biosynthesis ; Dietary purines and pyrimidines ; Orotic acid ; Allopurinol ; Orotidine-5-phosphate-decarboxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Young healthy volunteers received a purine-free, isoenergetic formula diet over a period of 28 to 32 days. After a short time under formula diet alone 400 mg allopurinol were administered daily. After a further 10 days each volunteer received daily, in addition, either 4 g RNA, 4 g RNA-hydrolysate, 1 g guanosine-5-monophosphate (GMP), 1 or 3 g adenosine-5-monophosphate (AMP), uridine-5-monophosphate (UMP), cytidine-5-monophosphate (CMP) or adenosine, guanosine, uridine, cytidine, guanine, hypoxanthine, xanthine, cytosine and uracil. Finally the allopurinol was omitted. The renal excretion of total orotic acid (orotic acid and orotidine), uric acid and creatinine was determined daily; serum uric acid concentration and the enzyme activities of orotidine-5-phosphate-decarboxylase (ODCase) and hypoxanthine-guanine-phosphoribosyltransferase (HGPRTase) from erythrocytes were determined every other day. The results show that RNA, RNA-hydrolysate, purine- and pyrimidines and -nucleosides as well as hypoxanthine, and to a lesser extent adenine, diminish allopurinol-induced orotaciduria. This is compatible with an influence of dietary purines and pyrimidines on human pyrimidine biosynthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01537430
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...