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  • 1
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 83-90 
    ISSN: 1432-1440
    Keywords: Collagen ; Marfan's syndrome ; Fibroblasts ; Aortic-aneurysm ; Kollagen ; Marfan-Syndrom ; Fibroblasten ; Aorten-Aneurysma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Fallbericht einer 33jährigen Frau mit einem ausgeprägtem Marfan-Syndrom wird vorgestellt. Sie hatte typische ossäre, okuläre, kardiovaskuläre und auch pulmonale Veränderungen, auf deren Bedeutung näher eingegangen wird. Wegen einer schweren Aorteninsuffizienz bei einem Aneurysma der Aorta ascendens und einer beträchtlichen Mitralinsuffizienz wurde ein Doppelklappenersatz durchgeführt und eine Prothese der Aorta ascendens eingesetzt. Die Prognose, die diagnostischen und therapeutischen Möglichkeiten der lebensbedrohlichen kardiovaskulären Komplikationen bei Marfan-Syndrom werden diskutiert. Das bei der Operation gewonnene Aortengewebe wurde histologisch und biochemisch analysiert. Histologisch zeigte sich eine typische Medianekrose. Biochemisch (Fibroblastenkultur, Elektronenmikroskopie) fand sich eine veränderte Zusammensetzung der kollagenen Anteile. Sowohl in der Adventitia wie in der Media war Kollagen Typ I nahezu völlig zugunsten von Kollagen Typ III verschwunden. Diese Verschiebung galt in gleicher Weise für die Prokollagene. In der Haut der Patientin fand sich jedoch eine normale Verteilung von Prokollagen und Kollagen der Typen I und III. Die weitgehende Reduktion von Kollagen Typ I stellt möglicherweise die Ursache der Wandschwächung der Aorta dar, die die Ursache der Aneurysmabildung und der Aorteninsuffizienz ist.
    Notes: Summary The case report on a 33 year old woman with prominent features of Marfan's syndrome is presented. Characteristic signs were seen in the bones, the eyes, the cardiovascular system, and the lungs. Due to regurgitation of both the aortic and mitral valves and an aneurysm of the ascending aorta a double valve replacement was made, including a prothesis of the aorta. The problems of early diagnosis and therapy of the life-threatening cardiovascular complications are discussed. Tissue specimens from the aorta were analysed histochemically and biochemically. Histology showed a typical necrosis of the media with cyst formation. Biochemical analysis by in vitro labeling of collagen in tissue explants and by electon microscopical evaluation showed proportions of type I and type III collagen which were significantly different from controls. In both the media and the adventitia the amount of type I collagen was drastically reduced as shown by quantitation of collagen and procollagen. Fibroblasts derived from the skin of the patient showed a normal content of type I and type III collagen. It is conceivable that the reduced content of type I collagen in the aortic wall is responsible for the weakness of the vessel wall causing formation of aneurysm and its sequelae.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 52 (1974), S. 605-607 
    ISSN: 1432-1440
    Keywords: Shock ; hypoglycemia ; hepatic failure ; Schock ; Hypoglykämie ; Schockleber
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 5 von 39 Patienten wurde während Kreislaufschock eine Hypoglykämie beobachtet. Die Blutzuckerwerte waren auf 12–25 mg-%, in einem Fall unter 5 mg-% vermindert. Biochemische und histologische Befunde machen eine hepatogene Genese der Hypoglykämie wahrscheinlich. Aufgrund der Beobachtungen werden häufige Blutzuckerkontrollen und routinemäßige Glucoseinfusionen während Kreislaufschock empfohlen. Bei Hypoglykämie ist eine intensive Glucosetherapie indiziert.
    Notes: Summary Hypoglycemia was observed during shock in 5 of 39 patients. Blood sugar levels ranged from 12 to 22 mg% and below 5 mg% in one case. Biochemical and histological findings suggest hepatic origin of the hypoglycemia. Based on these findings repeated blood sugar determinations and routine glucose infusions in shock are recommended. Hypoglycemia is an indication for intensive glucose therapy.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 52 (1974), S. 406-407 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 50 (1974), S. 265-266 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 45 (1973), S. 404 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0038-0717
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0789
    Keywords: Fatty acids ; Phospholipids ; Lipopolysaccharides ; Microbial biomass ; Gram-positive bacteria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract Several soils subject to different cultivation and management practices were examined by analysis of fatty acid profiles derived from phospholipids and lipopolysaccharides, using an improved sequential method which is capable of measuring ester-linked and non-ester-linked phospholipid fatty acids (EL-PLFA, NEL-PLFA, respectively) and the hydroxy fatty acids in lipopolysaccharides. A good correlation was obtained (r〉0.90) between the soil biomass and total EL-PLFA in the soils investigated, which ranged from forest soils to a variety of agricultural soils. Elucidation of the composition of the community structure was an additional task. Eukaryotes can be differentiated from bacteria by the presence of polyunsaturated and ω-hydroxy fatty acids, both of which were much more abundant in the OF layer of the forest soil than in the remaining samples. A relatively low proportion of monomethyl branched-chain saturated fatty acids was obtained in the forest OF horizon, these being indicators for Gram-positive bacteria and actinomycetes. Various subclasses of proteobacteria produce β and mid-chain hydroxy fatty acids, which occur primarily in agricultural soils. The ratios between monounsaturated fatty acids and saturated fatty acids seem to be very useful parameters of soil environmental conditions. In addition, on the basis of the differences in composition of the NEL-PLFA and hydroxy fatty acids of lipopolysaccharides, clear indications for the community structure of various soils were obtained. In the forest soils much more abundant anaerobic micro-organisms and relatively less abundant proteobacteria were present than in the other soils. In the cultivated soils, however, the proportion of Gram-negative bacteria was considerably higher. Furthermore, eukaryotes appeared to be pre-dominant in the soils once used for a manure deposit site.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Materials and structures 16 (1983), S. 259-267 
    ISSN: 1359-5997
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Description / Table of Contents: Résumé La résistance de matériaux ainsi vérifiée sur des spécimens de type, forme et âge normalisés est modélisée comme une progression gaussienne avec une valeur moyenne et un écart-type partiellement connus. Pour obtenir une information sur ces paramètres, il faut se servir d'unités de production précédentes en s'appuyant sur une distributiona priori. La mise à jour peut se faire par le théorème de Bayes, si des observations directes sont disponibles, ou s'il est connu que la production à venir va être soumise à certains essais de conformité. La progression des valeurs de résistances escomptées peut alors être représentée par un ensemble de fonctions de distribution conditionnelle ou, si l'on s'intéresse seulement à la distribution marginale, par une distribution prévisionnelle. Dans la plupart des cas, les formules sont dérivées en incluant la loi de distribution normale, la loi de distribution bi-normale, les distributions t centrales et non centrales, qui figurent toutes sous forme de tableau, ou peuvent être calculées par des expansions de séries appropriées, disponibles dans la littérature statistique. Les résultats sont illustrés par un exemple de production de béton, qui indique que, en général, des incertitudes dans les paramètres de la distribution de résistance peuvent avoir leur signification dans les études de fiabilité. Il est par conséquent tout indiqué de considérer que les incertitudes statistiques se reflètent dans la distributiona priori appropriée, si possible mise à jour par le moyen des études de fiabilité. De plus, l'effet filtrant favorable de contrôle de conformité peut être pris en considération avec peu d'effort numérique supplémentaire. Pour la plupart des types de matériaux, la distribution initiale des valeurs de résistances élémentaires peut être admise comme log-normal avec suffisamment de réalisme. Dans ce cas, tous les résultats restent valables avec les modifications nécessaires. Les modèles proposés ici peuvent être appliqués au moins au béton, béton armé et acier structurel.
    Notes: Abstract The joint distribution of strength of materials is derived in terms of a set of conditional distributions to be used in studies on structural reliability. Bayes theorem of probability theory is used to update prior distributions for the parameters of Gaussian sequences by direct observations and/or by compliance tests. Maximum-Likelihood estimators are given for the efficient quantification of prior information. The formulae are applied to concrete production judged by standard tests. It is shown that statistical uncertainties must not be ignored in structural reliability studies.
    Type of Medium: Electronic Resource
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