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  • 1990-1994  (5)
  • Engineering  (2)
  • Traditional Chinese herbal medicine  (2)
  • Combination therapy  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Protective effect of Shigyaku-to, a traditional Chinese herbal medicine, on the infection of herpes simplex virus type 1 (HSV-1) in mice (1994)
    Springer
    Cellular and molecular life sciences 50 (1994), S. 456-460 
    Details
    ISSN: 1420-9071
    Keywords: Traditional Chinese herbal medicine ; herpes simplex virus ; antiviral effects ; CD8+ T cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The antiviral activity of Shigyaku-to (TJS-109), a traditional Chinese herbal medicine, was investigated in mice infected with herpes simplex virus type 1 (HSV-1). TJS-109 is a combination of the medicinal plant extracts fromZingiberis siccatum rhizoma,Aconiti tuber andGlycyrrhizae radix in a specific proportion. Mice infected with a 10 LD50 dose of HSV-1 were treated with TJS-109 orally at doses of 1.25 to 20 mg/kg 2 days before, and 1 and 4 days after the infection. The treated groups had 80% (1.25 mg/kg), 40% (5 mg/kg) and 23% (20 mg/kg) mortality rates 25 days after the infection as compared with a 100% mortality rate in control mice treated with saline. When HSV-1 infected mice (recipients) received CD8+T cell fractions derived from spleens of mice treated with TJS-109 (donors), 70% of recipients survived, as compared with 0% survivors in the groups of mice treated with saline, B cell fractions, CD4+ T cell fractions or macrophage-enriched fractions prepared from the same donors. TJS-109 did not show any virucidal activities against HSV-1 or any virostatic activities on the growth of HSV-1 in Vero cells. These results suggest that TJS-109 protected mice exposed to lethal amounts of HSV-1 through the activation of CD8+ T cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01920746
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The antiviral effect of Keishi-ni-eppi-ichi-to, a tranditional Chinese herbal medicine, on influenza A2(H2N2) virus infection in mice (1994)
    Springer
    Cellular and molecular life sciences 50 (1994), S. 774-779 
    Details
    ISSN: 1420-9071
    Keywords: Traditional Chinese herbal medicine ; antiviral effect ; influenza virus ; a mouse model
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The antiviral effect of Keishi-ni-eppi-ichi-to (TJS-064), a traditional Chinese herbal medicine, was investigation in mice infected with influenza A2(H2N2) virus. When mice exposed to 5 LD50 dose of the virus were treated orally with a 70 mg/kg dose of TJS-064 1 day before and 1 day and 4 days after the infection, 100% survived over a 25-day experimental period. At the end of this period all the control mice, treated with saline alone, had died; their mean survival time in days (MSD) was 11.2 days. When mice infected with a 10 LD50 dose of the virus were treated with TJS-064, the MSD was 〉17.4 days and there was a 50% survival rate, while the control group had a MSD of 8.7 days and 0% survival rate. No significant antiviral effect TJS-064 was observed when the agent was administered orally to mice infected with a 100 LD50 or large dose of influenza virus. Pulmonary consolidation, virus titers in lung tissues and HAI titers in sera of infected mice treated with TJS-064 were all significantly lower than those of infected mice treated with saline. Interferon activities were detected in sera of mice treated with the agent at a dose of 100 mg/kg orally. Since viricidal and viristatic activities of the agent against influenza virus were not demonstrated, the antiviral effects of TJS-064 may be expressed through the host's antiviral functions including interferon production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01919381
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Failure of combination therapy with recombinant granulocyte colony-stimulating factor and erythropoietin in myelodyspplastic syndromes (1994)
    Springer
    Annals of hematology 68 (1994), S. 163-166 
    Details
    ISSN: 1432-0584
    Keywords: MDS ; Cytokine ; G-CSF ; EPO ; Combination therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recombinant human granulocyte colonystimulating factor (rhG-CSF) and erythropoietin (rhE-PO) were used to treat ten patients with myelodysplastic syndromes (MDS). None of the patients showed a favorable response in erythrocyte and platelet counts following 10 weeks' treatment, although favorable responses in neutrophil counts were observed in eight of ten patients (80.0%) and in seven of eight patients (87.5%) following 2 weeks' and 10 weeks' treatment, respectively. However, one patient with refractory anemia had a delayed favorable response in erythrocyte and neutrophil counts at week 14 in spite of the cessation of combination therapy at week 10. These results indicate that combination therapy with rhG-CSF and rhEPO is not beneficial to patients with MDS, based on the presently used protocol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834360
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Numerical comparison of momentum interpolation methods and pressure - velocity algorithms using non-staggered grids (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 7 (1991), S. 173-186 
    Details
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Finite-volume calculations of laminar separated flow around a fence are presented using a non-staggered grid system. Using the pressure-weighted interpolation method (PWIM), the role of the under-relaxation factor in this method has been studied. The performance of two pressure-velocity coupling algorithms, viz. SIMPLE and PISO, have been compared as well as the solution fields obtained using non-staggered and staggered grids. A detailed study has been conducted to investigate the occurrence of physically unrealistic convective velocities in the solution fields.The numerical results show that solutions obtained using non-staggered grids are as accurate as those obtained using staggered grids. The presence of very small under/overshoots in the estimated convective fluxes is related to the simultaneous presence of high Péclét numbers and rapidly varying pressure gradients. However, for the complex separated flow investigated, no induced errors were detected in the solution field.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cnm.1630070302
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Comparison of several open boundary numerical treatments for laminar recirculating flows (1993)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 16 (1993), S. 403-419 
    Details
    ISSN: 0271-2091
    Keywords: Outflow boundary conditions ; Laminar recirculating flows ; Non-staggered grid systems ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Several open boundary conditions (OBCs) are compared and evaluated in the framework of the SIMPLE algorithm using staggered and non-staggered grid systems. The benchmark laminar flow test cases used for the OBC evaluation are Poiseuille-Benard flow in a channel and stratified backward-facing step flow. The investigated OBCs are linear explicit step space extrapolation, Orlanski's monochromatic wave, and pressure extrapolation. Orlanski's and pressure extrapolation open boundary treatment for unsteady and steady flows, respectively, yield little reflection and has proved to be adequate for engineering calculations.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/fld.1650160505
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    Paper (German National Licenses)
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