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  • 1990-1994  (3)
  • Engineering  (2)
  • Combination therapy  (1)
  • 1
    ISSN: 1432-0584
    Schlagwort(e): MDS ; Cytokine ; G-CSF ; EPO ; Combination therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Recombinant human granulocyte colonystimulating factor (rhG-CSF) and erythropoietin (rhE-PO) were used to treat ten patients with myelodysplastic syndromes (MDS). None of the patients showed a favorable response in erythrocyte and platelet counts following 10 weeks' treatment, although favorable responses in neutrophil counts were observed in eight of ten patients (80.0%) and in seven of eight patients (87.5%) following 2 weeks' and 10 weeks' treatment, respectively. However, one patient with refractory anemia had a delayed favorable response in erythrocyte and neutrophil counts at week 14 in spite of the cessation of combination therapy at week 10. These results indicate that combination therapy with rhG-CSF and rhEPO is not beneficial to patients with MDS, based on the presently used protocol.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 7 (1991), S. 173-186 
    ISSN: 0748-8025
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: Finite-volume calculations of laminar separated flow around a fence are presented using a non-staggered grid system. Using the pressure-weighted interpolation method (PWIM), the role of the under-relaxation factor in this method has been studied. The performance of two pressure-velocity coupling algorithms, viz. SIMPLE and PISO, have been compared as well as the solution fields obtained using non-staggered and staggered grids. A detailed study has been conducted to investigate the occurrence of physically unrealistic convective velocities in the solution fields.The numerical results show that solutions obtained using non-staggered grids are as accurate as those obtained using staggered grids. The presence of very small under/overshoots in the estimated convective fluxes is related to the simultaneous presence of high Péclét numbers and rapidly varying pressure gradients. However, for the complex separated flow investigated, no induced errors were detected in the solution field.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 16 (1993), S. 403-419 
    ISSN: 0271-2091
    Schlagwort(e): Outflow boundary conditions ; Laminar recirculating flows ; Non-staggered grid systems ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: Several open boundary conditions (OBCs) are compared and evaluated in the framework of the SIMPLE algorithm using staggered and non-staggered grid systems. The benchmark laminar flow test cases used for the OBC evaluation are Poiseuille-Benard flow in a channel and stratified backward-facing step flow. The investigated OBCs are linear explicit step space extrapolation, Orlanski's monochromatic wave, and pressure extrapolation. Orlanski's and pressure extrapolation open boundary treatment for unsteady and steady flows, respectively, yield little reflection and has proved to be adequate for engineering calculations.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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