ISSN:
1432-0428
Keywords:
Key words Diabetes mellitus, complications, brain, cerebral dysfunction, cognitive dysfunction, pathogenesis, cerebral blood flow, hypoglycaemia, hyperglycaemia, review.
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Diabetes mellitus is a common metabolic disorder associated with chronic complications such as nephropathy, angiopathy, retinopathy and peripheral neuropathy. Diabetes is not often considered to have deleterious effects on the brain. However, long-term diabetes results in a variety of subtle cerebral disorders, which occur more frequently than is commonly believed. Diabetic cerebral disorders have been demonstrated at a neurochemical, electrophysiological, structural and cognitive level; however, the pathogenesis is still not clear. Probably alterations in cerebral blood supply and metabolic derangements play a role, as they do in the pathogenesis of diabetic neuropathy. Furthermore, the brain is also affected by recurrent episodes of hypoglycaemia and poor metabolic control. We describe herein the cerebral manifestations of diabetes and discuss the putative pathogenetic mechanisms. [Diabetologia (1994) 37: 643–650]
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00417687
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