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  • 1990-1994  (3)
  • Vigna unguiculata  (2)
  • Felodipine  (1)
  • 1
    ISSN: 1432-1041
    Keywords: Felodipine ; β-blocker ; combination therapy ; essential hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the efficacy and tolerability of felodipine plus a β-adrenoceptor blocker in 79 patients with essential hypertension previously treated with a combination of three or more anti-hypertensive agents, one of which was a β-adrenoceptor blocker. After a 4-week run-in period on the same β-blocker plus placebo (as a substitute for the other agents in the regimen), felodipine was added and its dose titrated to achieve a supine diastolic blood pressure or less than 90 mm Hg. This was followed by a 12-week maintenance phase in all patients, and 47 patients entered an optional long-term follow-up for an additional 9 months. The mean supine blood pressure was 149/88 mm Hg at entry and 174/108 mm Hg after the run-in phase. Felodipine significantly reduced the blood pressure to 142/85 mm Hg after dose titration and to 141/84 mm Hg after 12 weeks, 94% of patients achieving a supine diastolic blood pressure of 90 mm Hg or below. This reduction was maintained in the patients who were followed for 12 months. The adverse events recorded were usually mild, transient, and typical for an effective precapillary vasodilator. Nine of 74 patients (11%) were withdrawn in the first phase of the study because of adverse events and 5 of 47 patients were withdrawn during the long-term follow-up. These results show that the efficacy and tolerability of a combination of felodipine with a β-blocker allow a simplified regimen for hypertensive patients who were previously taking three or more drugs for satisfactory blood pressure control.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5060
    Keywords: Striga gesnerioides ; Vigna unguiculata ; cowpea ; parasitic angiosperm ; breeding for resistance ; parasite variation ; races
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract An in vitro growth system was used to determine the virulence of two samples of Striga gesnerioides from Zakpota in southern Benin. Cowpea variety B301, previously considered resistant to all races of S. gesnerioides, was susceptible to both samples of the parasite. Two other cowpea varieties, 58–57 and IT81D-994, were totally resistant. Resistance in 58–57 was associated with a hypersensitive necrosis of infected roots, whilst IT81D-994 supported production of small S. gesnerioides tubercles with stems which failed to develop. Striga gesnerioides from southern Benin is the fourth race of the parasite to be identified, and the first with virulence on variety B301. The implications for breeding cowpeas with resistance to S. gesnerioides are discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-5060
    Keywords: cowpea ; intercropping ; Nigeria ; yield stability ; Vigna unguiculata
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Nine cowpea (Vigna unguiculata (L.) Walp.) breeding lines were grown in 13 experiments under sole crop and intercrop management, with and without insecticide application, in Nigeria. Cowpea was intercropped with cassava (Manihot esculenta Cranz), maize (Zea mays L.) and maize-cassava in the forest zone and with sorghum (Sorghum bicolor Moench.) and millet (Pennisetum glaucum (L.) R.Br.) in the savanna zone. Line by cropping system interactions were significant in 5 of 13 experiments and line by insecticide treatment interactions were significant in 2 of 13 experiments. Cowpea yield was severely depressed in intercropped plots and in plots to which no insecticide was applied. Among-environment variation in cowpea yield was greater when no insecticide was applied. Within each management treatment, the yield performance and stability of the cowpea lines was examined. Stability was assessed both by examining among-environment coefficients of variation and by regression analysis. Several of the breeding lines evaluated appeared promising under different levels of management and in a diversity of environments.
    Type of Medium: Electronic Resource
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