ISSN:
1432-0533
Keywords:
KeyWordsAcromegaly
;
Pituitary gland
;
Growth hormone
;
Gonadotropin α-subunit
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Thirty-one consecutive cases of pituitary adenoma in acromegalic patients were studied by immunohistochemistry. All adenomas contained cells immunoreactive with the anti-α-subunit of gonadotropic hormones (α; 0.6 – 53 % of tumor cells) as well as with anti-growth hormone (GH; 4 – 74 % of tumor cells). In serial section study, most cells immunoreactive with anti-α were identical to cells immunoreactive with anti-GH. There was a positive correlation between the percentages of cells immunoreactive for α in GH cells [α(%)/GH(%)] and those for prolactin (PRL) in immunoreactive tumor cells ♪PRL(%)/[PRL(%)+GH(%)]♪ in mixed GH cell-PRL cell adenomas, suggesting that the α-subunit may play a role in emergence of PRL cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00293316
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