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  • 1990-1994  (2)
  • Invasion  (1)
  • Pollen sterility  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Expression of matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) induced by tumour necrosis factor α correlates with metastatic ability in a human osteosarcoma cell line (1994)
    Springer
    Virchows Archiv 424 (1994), S. 547-552 
    Details
    ISSN: 1432-2307
    Keywords: Osteosarcoma ; Invasion ; Metastasis ; Matrix metalloproteinase ; Tumour necrosis factor α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have examined the correlation between matrix metalloproteinase (MMP) expression and metastatic properties of a low metastatic osteosarcoma cell line, osteosarcoma takase (OST), under stimulation by tumour necrosis factor α (TNFα). In vivo, OST cells exhibited significantly increased colonization in the lungs of nude mice in a dose-dependent manner when they were treated by TNFα prior to injection. In vitro, TNFα enhanced tumour cell invasion through the reconstituted basement membrane in a transwell chamber up to 2.5-fold. Gelatin zymography and sandwich enzyme immunoassays demonstrated marked production of MMP-9 [92-kDa gelatinase/type IV collagenase (gelatinase B)] but not MMP-2 [72-kDa gelatinase/type IV collagenase (gelatinase A)], MMP-3 (stromelysin-1) or MMP-7 (matrilysin). Motility of the tumour cells and adhesion to cultured endothelial cells were slightly increased by the TNFα treatment up to 1.6-fold and 1.4-fold, respectively, while the growth rate was decreased. These results suggest that upregulation of MMP-9 together with enhanced motility and endothelial adhesion contribute to the increased metastatic ability of OST cells induced by TNFα treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00191442
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Segregation distortion via male gametes in hybrids between Indica and Japonica or wide-compatibility varieties of rice (Oryza sativa L) (1992)
    Springer
    Theoretical and applied genetics 84 (1992), S. 812-818 
    Details
    ISSN: 1432-2242
    Keywords: Rice ; Segregation distortion ; Wide cross ; Pollen sterility ; Wide compatibility variety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary One or two marker genes on each of chromosomes 3, 4, 6, 7, 8, 11 and 12 of the 12 rice chromosomes were tested for segregation distortion in indica-japonica hybrids. Marker genes on chromosomes 3, 7, 8, 11 and 12 showed clear segregation distortion. This distortion was not related to the proportion of normal pollen. The germinability of the pollen was less than 10% in the hybrids, although 45–55% of the pollen grains appeared to be morphologically normal. The frequent occurrence of segregation distortion and the low germinability of the pollen grains suggested that a large portion of the pollen produced by the Indica-Japonica hybrids was not functional. The fact that the segregation distortion of the same marker may be positive or negative depending on the cross combination suggested the existence of multiple alleles, including distortion-neutral alleles. The latter mitigate pollen sterility in certain hybrid combinations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227389
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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