Bibliothek

feed icon rss

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • 1990-1994  (2)
  • Key words Animal models NIDDM, insulin secretion, insulin mRNA, cytochrome b mRNA, islets of Langerhans.  (1)
  • Mental symphysis  (1)
Materialart
Erscheinungszeitraum
  • 1990-1994  (2)
Jahr
Schlagwörter
  • 1
    ISSN: 1432-0428
    Schlagwort(e): Key words Animal models NIDDM, insulin secretion, insulin mRNA, cytochrome b mRNA, islets of Langerhans.
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Animals with NIDDM display abnormal glucose regulation of insulin secretion and biosynthesis. We tested reversibility of abnormal regulation by normoglycaemia using an islet transplantation technique. Inbred non-diabetic and neonatally STZ diabetic rats (n-STZ) were used. Transplantations insufficient to normalize the blood glucose levels (200 islets under kidney capsule) were performed from diabetic to normal (D-N) and from diabetic to diabetic (D-D), as well as from normal to normal (N-N) and from normal to diabetic (N-D) rats. Four weeks after transplantation, graft bearing kidneys were isolated and perfused with Krebs-Henseleit bicarbonate buffer to measure insulin secretion in response to 27.8 mmol/l glucose and 10 mmol/l arginine. Four weeks of normoglycaemia failed to restore glucose-induced insulin secretion from n-STZ islets (glucose induced increment: −1.7± 2.5 fmol/min in D-N, 1.2±7.1 fmol/min in D-D). In contrast to normal islets, normoglycaemia reduced insulin mRNA contents (60±24 in D-N, 496±119 in D-D; O. D.-arbitrary units). However, arginine-induced secretion was markedly enhanced by diabetic environment in both normal and n-STZ islet grafts. These results indicate that selected aspects of glucose recognition are irreversibly damaged by a long-term diabetic state or, alternatively, by a lasting effect of STZ administration. [Diabetologia (1994) 37: 351–357]
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Surgical and radiologic anatomy 16 (1994), S. 379-384 
    ISSN: 1279-8517
    Schlagwort(e): Mental symphysis ; Secondary cartilage ; Ossification
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Résumé La présence d'un cartilage secondaire dans la région de la symphyse mentonnière a été étudiée dans ce travail. Une double coloration (avec le bleu alcian et le rouge alizarine S) a été réalisée sur 32 embryons et foetus humains (âgés de 8 à 17 semaines, longueur crâniocaudale- CRL - entre 37 et 124 mm) et sur leurs mandibules désarticulées. Les techniques histologiques et histochimiques ont été appliquées aux coupes sériées transversales de toutes les têtes foetales désarticulées. Le processus d'ossification observé au niveau de la symphyse mentonnière est tout à fait différent de celui du corps de la mandibule dont l'ossification membraneuse est induite par le cartilage de Meckel contigu. Nous n'avons détecté aucun signe de fusion du cartilage de Meckel avec le cartilage symphysaire qui se trouve dans l'espace symphysaire. Sur la base de nos constatations, nous suggérons que le cartilage secondaire mentonnier est capable de se transformer en os selon un processus d'ossification enchondrale. De plus le rôle des facteurs mécaniques dans le développement de la symphyse mentonnière est suggéré.
    Notizen: Summary The presence of a secondary cartilage in the mental symphyseal region was examined in this study. A double-staining method -with alcian blue and alizarin red S -was performed on both whole human embryos and fetuses (developmental age between 8 and 17 weeks, crown-rump length, CRL, between 37 and 124 mm) and their disjointed mandibles. Histological and histochemical techniques were applied to transverse serial sections of whole disjointed fetal heads. The ossification process observed in the mental symphysis is quite different from that of the mandibular body, whose membranous ossification is induced by the contiguous Meckel's cartilage. No evidence of any fusion of Meckel's cartilage with the symphyseal cartilage, that lies within the symphyseal space, was detected. On the basis of these findings, we suggested that the mental secondary cartilage is able to change into bone according to an endochondral ossification process. Moreover, the role of mechanical causes in the development of the mental symphysis was hypothesized.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
    BibTip Andere fanden auch interessant ...
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...