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  • 1: advanced search Author, Corporation: Shimizu, M.   :    :   —  4 hits    Redo Search Permalink feed icon
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  • 1990-1994  (2)
  • L2/HNK-1 carbohydrate  (1)
  • Myocardial scintigraphy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Serial change of iodine-123 metaiodobenzylguanidine (MIBG) myocardial concentration in patients with dilated cardiomyopathy (1992)
    Springer
    European journal of nuclear medicine 19 (1992), S. 265-270 
    Details
    ISSN: 1619-7089
    Keywords: Dilated cardiomyopathy (DCM) ; Myocardial scintigraphy ; 123I-Metaiodobenzylguanidine (MIBG)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serial change of the metaiodobenzylguanidine iodine-123 (123I-MIBG) myocardial concentration was investigated in patients with dilated cardiomyopathy (DCM). Eight DCM patients and 6 control subjects were examined. After the injection of thallium-201 and 123I-MIBG, planar chest images were obtained simultaneously for both tracers in every 30–60 min over 5 h. Serial changes of myocardial uptake ratio (MUR) were compared for both tracers. In DCM, the initial MUR of 123I-MIBG did not differ significantly from that of the controls. The washout of 123I-MIBG from the myocardium, however, was significantly increased in DCM. In particular, the decrease in the early phase (15–45 min) was significantly larger in DCM than in the controls (21.2%±7.5% vs. 5.3%±4.0%, P 〈0.01), showing a significant negative correlation with the left ventricular ejection fraction (r = −0.72 P 〈 0.05). For 201TI, neither the initial MUR nor the washout rate different significantly between the two. Thus, an early rapid decrease of the 123I-MIBG myocardial concentration might characterize DCM and reflect the severity of this disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175140
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Determination of structural elements of the L2/HNK-1 carbohydrate epitope required for its function (1994)
    Springer
    Glycoconjugate journal 11 (1994), S. 345-352 
    Details
    ISSN: 1573-4986
    Keywords: L2/HNK-1 carbohydrate ; antibody recognition ; laminin binding ; neural migration and process outgrowth
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The L2/HNK-1 carbohydrate epitope has been shown to carry an unusual 3′-sulfoglucuronic acid linkedO-glycosidically through a neolactosyl-type back bone to a ceramide residue. Using monoclonal antibodies, the same or a closely related epitope has also been detectedN-glycosidically linked to glycoproteins, amongst them several neural cell adhesion molecules. We used synthetic glycolipids carrying sulfated or non-sulfated glucuronic acid attached to ceramide through glycans of different length to show that not only the sulfated glucuronic acid but also the neolactosyl-type backbone is essential for the recognition of the L2/HNK-1 carbohydrate by a monoclonal antibody, its binding to laminin and its role in neural cell migration and outgrowth of processes from neurons and astrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00731208
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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