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Elevated plasma nilvadipine concentration after single and chronic oral administration to patients with chronic liver disease (1992)

Takata, Y. ; Yoshizumi, T. ; Ito, Y. ; [et al.]

Springer

European journal of clinical pharmacology 42 (1992), S. 475-479

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ISSN: 1432-1041

Keywords: Calcium channel blocker ; Nilvadipine ; blood pressure ; liver disease ; pharmacokinetics ; pharmacodynamics ; cirrhosis ; hepatitis

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Fourteen normotensive patients with liver disease (6 with cirrhosis and 8 with chronic hepatitis) and 7 healthy volunteers were given a single oral dose of nilvadipine 2 mg. In addition, nilvadipine 4 mg was administered orally twice daily for several months to 6 hypertensive patients with mild liver dysfunction and 18 hypertensives with normal liver function. A significant increase in plasma nilvadipine was found in the patients with cirrhosis as compared both to the normal and chronic hepatitis subjects; the time to peak concentration was similar among the three groups. The peak plasma nilvadipine concentration was closely correlated both with the serum albumin level and the retention of indocyanine green. Changes in blood pressure, pulse rate and various vasoactive hormones following a single oral dose of nilvadipine did not differ between the groups. Thus, an increase in plasma nilvadipine relative to the level in normal subjects was demonstrated in patients with cirrhosis following a single oral dose, as well as in patients with slight liver dysfunction following long-term oral administration.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00314853

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Antifogging effect of cellulose films by chemical modification of the surface using nonionic fluorocarbon surfactant (1990)

Ueno, M. ; Ugajin, Y. ; Horie, K. ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 39 (1990), S. 967-977

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ISSN: 0021-8995

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: Wettability and antifogging effect on the surface of the transparent thin film of cellulose esters were studied by fixing chemically nonionic fluorocarbon surfactants on the film surface and were compared with the properties of the surface fixed with the corresponding nonionic hydrocarbon surfactants. These antifogging properties on the surfaces covered by the monomolecular layer of fluorocarbon surfactant were found to be more excellent than those of the nonionic hydrocarbon surfactants from the measurement of contact angle for water droplets and also from the data of Zisman's plots. The surface of the thin film setting in the closed chamber filled with water vapor at 60°C were confirmed to be transparent during a long time without fogging. Antifogging effect may be due to so-called double structure consisting of fluorocarbon and nonionic ethyleneoxide chains in the monomolecular layer.

Additional Material: 5 Ill.