ISSN:
1573-7373
Keywords:
angiogenesis
;
angiogenesis inhibitor
;
TNP-470
;
malignant glioma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A novel angiogenesis inhibitor TNP-470 was investigated for its anti-tumor activity against malignant gliomas bothin vitro andin vivo. TNP-470 cytostatically inhibited the growth in all of the seven glioma cell lines in culture including anticancer drug resistant cells. The 50% inhibitory concentrations (IC50) of these glioma cell lines were 10 to 30 Μg/ml and they were 10 to 20 times higher than IC50 of normal endothelial cells. TNP-470 (30 mg/kg, i.p., every other day) also significantly inhibited the tumor growth of T98G-transplanted nude mice. Microscopically, tumor vessels after the treatment of the tumor-bearing mice with TNP-470 became fewer in number and smaller in diameter than those without treatment. Furthermore, there appeared extensive necrotic areas in the tumor with TNP-470. These results indicate that TNP-470 is a potent angiogenesis inhibitor for malignant gliomas. In addition, the studies of labeling index of BrdU and Ki67 suggest that TNP-470 may act mainly on tumor endothelial cells, thus resulting in reduction of the tumor growth.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01053279
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