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  • 1990-1994  (2)
  • Time-dependent  (1)
  • dose effect relationship  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 44 (1993), S. 415-421 
    ISSN: 1432-1041
    Keywords: Clinical pharmacology ; Systolic time intervals ; dose effect relationship ; non-invasive method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Conclusion Heart rate-corrected STI integrate and reflect changes in ventricular inotropy, preload and afterload. STI represent a global method for the evaluation of cardiovascular performance, provided very well controlled study designs, including positive and negative controls and strictly standardised conditions are followed. STI are accurate, economic, reproducable and are very sensitive. They represent a useful non-invasive tool in clinical pharmacology for assessing the influence of drugs, their dose-effect relationships, and the time course of their effects on the cardiovascular system.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 17 (1993), S. 271-289 
    ISSN: 0271-2091
    Keywords: Least-squares finite element method ; Time-dependent ; Incompressible flows ; Bqussinesq approximation ; Navier-Stokes equations ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: The time-dependent Navier-Stokes equations and the energy balance equation for an incompressible, constant property fluid in the Boussinesq approximation are solved by a least-squares finite element method based on a velocity-pressure-vorticity-temperature-heat-flux (u-P-ω-T-q) formulation discretized by backward finite differencing in time. The discretization scheme leads to the minimization of the residual in the l2-norm for each time step. Isoparametric bilinear quadrilateral elements and reduced integration are employed. Three examples, thermally driven cavity flow at Rayleigh numbers up to 106, lid-driven cavity flow at Reynolds numbers up to 104 and flow over a square obstacle at Reynolds number 200, are presented to validate the method.
    Additional Material: 12 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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