ISSN:
1573-2568
Keywords:
primate
;
gastric acid
;
gastric pH
;
serum gastrin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Significant species differences have been demonstrated in gastric physiology, a factor that limits extrapolation of animal data to man. Primate physiology is thought to be similar to that of man; however, gastric function has not been adequately documented in the primate. In the present study six baboons (body weight 25.5±1.8 kg) were trained to sit in a chair and gastric acid secretion and gastrin release was studied in conscious animals. Mean basal acid secretion was 1.3±0.1 mmol (H+)/hr. Maximum output after pentagastrin (12 μg/kg/hr) was 9.5±0.9 mmol (H+)/hr and 11.0±0.4 mmol (H+)/hr after histamine (40 μg/kg/hr). A statistically significant (by cosinor analysis) circadian rhythm was demonstrated for intragastric pH over 24 hr in fasted baboons (P〈0.001). Mean basal serum gastrin level was 37.7±8.3 pg/ml. The integrated gastrin response after administration of a protein rich meal was 2.52±0.07 ng×min/ml and this increased to 5.17±0.18 ng×min/ml (P〈0.05) following simultaneous administration of a meal with atropine (0.2 mg/kg) (P〈0.05). Our results suggest that there is significant basal and stimulated acid secretion in the baboon; the amount of acid secreted is similar to that reported in man. Gastric pH demonstrated a circadian rhythm. Postprandial gastrin release was significantly enhanced by cotreatment with atropine. As the present findings are similar to those previously reported in man, the baboon may be a useful model for further studies in gastric physiology and experimental peptic ulceration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01295997
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