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  • 11
    Electronic Resource
    Electronic Resource
    A family of selective immunodeficiency with normal immunoglobulins: possible autosomal dominant inheritance (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 328-332 
    Details
    ISSN: 1432-1076
    Keywords: Key words: Specific antibody deficiency – Autosomal dominant TSST-1 – Toxic shock syndrome – Staphylococcal infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We report here our findings in two Japanese siblings who experienced recurrent bacterial and viral infections since early infancy. Recent symptoms included diarrhoea, conjunctivitis, rashes, headache, sore throat, joint pain, vomiting and vertigo, all similar to those seen in toxic shock syndrome, except for shock. These symptoms improved following gammaglobulin treatment. Staphylococcus aureus with coagulase type IV was continuously isolated from nasal smears producing toxic shock syndrome toxin-1 (TSST-1). Serum antibodies did not or only poorly responded to TSST-1, diphtheria toxoid, varicella virus and rubella virus, whereas total and subclass levels of serum immunoglobulin and in vitro DNA synthesis of lymphocytes stimulated by TSST-1, Staph. aureus, varicella vaccine and mitogens were normal. In the family, ten other members in three generations (five males : five females) including the mother had similar clinical symptoms. Thus, the disease may be inherited in an autosomal dominant fashion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956412
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Criss-cross heart evaluated by colour Doppler echocardiography and magnetic resonance imaging (1990)
    Springer
    European journal of pediatrics 149 (1990), S. 523-525 
    Details
    ISSN: 1432-1076
    Keywords: Criss-cross heart ; Two-dimensional echodardiography ; Colour Doppler echocardiography ; Magnetic resonance imaging ; Congenital heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two-dimensional colour Doppler echocardiography was performed on a 1-month-old male infant with criss-cross heart, double outlet right ventricle, ventricular septum defect and pulmonary stenosis. Complex structural abnormalities were suspected after two-dimensional echocardiography (2-D echo) and confirmed by colour Doppler and magnetic resonance imaging (MRI). We stress that the blood streams in the ventricular inflow tracts revealed by colour Doppler and the spatial relationships of the cardiac segments disclosed by MRI are essential to make an accurate non-invasive diagnosis of this complex malformation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957683
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    A family of selective immunodeficiency with normal immunoglobulins: possible autosomal dominant inheritance (1994)
    Springer
    European journal of pediatrics 153 (1994), S. 328-332 
    Details
    ISSN: 1432-1076
    Keywords: Specific antibody deficiency ; Autosomal dominant ; TSST-1 ; Toxic shock syndrome ; Staphylococcal infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report here our findings in two Japanese siblings who experienced recurrent bacterial and viral infections since early infancy. Recent symptoms included diarrhoea, conjunctivitis, rashes, headache, sore throat, joint pain, vomiting and vertigo, all similar to those seen in toxic shock syndrome, except for shock. These symptoms improved following gammaglobulin treatment.Staphylococcus aureus with coagulase type IV was continuously isolated from nasal smears producing toxic shock syndrome toxin-1 (TSST-1). Serum antibodies did not or only poorly responded to TSST-1, diphtheria toxoid, varicella virus and rubella virus, whereas total and subclass levels of serum immunoglobulin and in vitro DNA synthesis of lymphocytes stimulated by TSST-1,Staph. aureus, varicella vaccine and mitogens were normal. In the family, ten other members in three generations (five males: five females) including the mother had similar clinical symptoms. Thus, the disease may be inherited in an autosomal dominant fashion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01956412
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Human T-cell leukemia virus type 1 protease protein expressed inEscherichia coli possesses aspartic proteinase activity (1993)
    Springer
    Archives of virology 128 (1993), S. 195-210 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We amplified the human T-cell leukemia virus type 1 (HTLV-1) protease gene fragment by polymerase chain reaction (PCR) and cloned it into a pUC plasmid vector. DNA sequencing data of the protease gene fragment indicated that it contained an open reading frame capable of encoding the active HTLV-1 protease. To express a fusion protein of β-galactosidase linked with the HTLV-1 protease inEscherichia coli, a plasmid DNA was constructed by inserting the HTLV-1 protease gene DNA into a procaryotic expression vector, pUEX2, consisting of alacZ gene directed by a λ phage Pr promoter and designated pUEX-pro. By Western blot analysis using anti-β-galactosidase antibody, a bigger molecular size band than that of the control β-galactosidase molecule was observed inE. coli cells transformed with pUEX-pro but not with control pUEX 2, suggesting that the particular fusion protein was successfully expressed. This recombinant protease protein in theE. coli cell lysate was demonstrated to be able to cleave the decapeptide substrates composed of amino acid sequences containing proteolytic cleavage sites in the HTLV-1gag precursor polyprotein. Thegag precursor polyprotein expressed in the mammalian cells by the recombinant vaccinia virus system was also expectedly cleaved by this enzyme. Significant inhibition of this protease activity by pepstatin A, an aspartic proteinase-specific inhibitor, confirms that HTLV-1 protease is a member of the aspartic proteinase group as suggested previously. Since the crude lysate without purification is utilized sufficiently as a native HTLV-1 protease reagent, this protease preparation is easily applicable to the large scale screening of HTLV-1 protease inhibitors for the treatment of diseases caused by HTLV-1.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01309434
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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