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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of S(+)- and R(−)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 493-497 
    Details
    ISSN: 1432-1041
    Keywords: ibuprofen ; rheumatoid arthritis ; enantiomer ; stereoselectivity ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary S(+)-, R(−)- or racemic ibuprofen was administered orally to volunteers in doses of 150 mg, 300 mg and 500 mg pure S(+)-, 300 mg pure R(−)- and 600 mg racemic ibuprofen. The pharmacokinetic parameters in humans showed that S(+)-ibuprofen was not inverted to R(−)-ibuprofen, whereas R(−)-ibuprofen was inverted to S(+)-ibuprofen to a variable degree. S(+)-ibuprofen and R(−)-ibuprofen given alone more rapidly reached significantly higher maximal plasma concentrations than after the same doses of the racemic compound. The elimination half-lives and clearance values for all three forms of ibuprofen were comparable. The mean residence time of S(+)-ibuprofen after R(−)- and racemic ibuprofen was significantly longer than after administration of the pure S(+)-enantiomer. Judged by the AUC, the bioavailability of S(+)-ibuprofen was independent of the dose within the range tested. Administration of S(+)-ibuprofen to 6 rheumatic patients showed that the pharmacokinetic behaviour of S(+)-ibuprofen in patients was similar to that found in volunteers. S(+)-ibuprofen proved to be an effective analgesic antirheumatic drug in the dose range 1 to 1.5 g/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02336690
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  • 2
    Electronic Resource
    Electronic Resource
    S-Ibuprofen versus ibuprofen-racemate (1991)
    Springer
    Rheumatology international 11 (1991), S. 199-202 
    Details
    ISSN: 1437-160X
    Keywords: Ibuprofen ; Enantiomers ; Rheumatoid arthritis ; Prostaglandins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ibuprofen (ibu) is a racemic 2-arylpropionic acid non-steroidal anti-inflammatory drug whose activity is due mainly to the S-enantiomer. So far only the racemic compound is in clinical use. A double-blind randomized trial was carried out for a 2-week period in 50 patients with classical rheumatoid arthritis (RA) (Steinbrocker II–III) to compare the effectiveness and tolerance of S-ibu (400 mg T.I.D.) with that of the racemic compound (600 mg T.I.D.). Ritchie-index, limitation of movement, joint pain on pressure and pain at night decreased significantly in both groups. Due to lack of effectiveness, the dose had to be increased in 3 patients from the S-ibu group as well as in 6 patients from the racemic group resulting in mean daily doses of 1220 mg S-ibuprofen and 1870 mg racemic ibu. No statistically significant difference could be found between both groups concerning efficacy and unwanted effects. Therefore, S-ibu given alone may be advantageous because the metabolic load to the human body is reduced and patients are more likely to comply with drug doses of 1.2 g/day as compared to 1.8 g/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332562
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hunter syndrome in Jews in Israel: further evidence for prenatal selection favoring the Hunter allele (1991)
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 531-533 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Among all the Jewish families with Hunter patients in Israel, 10 were Ashkenazi or Moroccan in origin. In those families, there was a paucity of new mutations. In addition, a significant deviation of the segregation ratio between the Hunter gene and the normal allele was demonstrated among the offspring of heterozygous mothers or siblings of affected children in these families. These results confirm and extend our previous observations suggesting selection in favor of the X chromosome carrying the Hunter allele among Ashkenazi and Moroccan Jews.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194650
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  • 4
    Electronic Resource
    Electronic Resource
    Non-self-similar blast waves (1991)
    Springer
    Combustion, explosion and shock waves 27 (1991), S. 342-351 
    Details
    ISSN: 1573-8345
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Conclusions Among the three non-self-similar methods studied in this paper, namely, the perturbation methods in η and y and the density-profile method, the latter method gives the best estimates of blast parameters in a wide range of shock-wave intensities. This work was performed with support from the Council on Natural Sciences and Technical Research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789669
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    Paper (German National Licenses)
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