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Effect of various antihypertensive drugs on the physical performance of a healthy person (1991)

Bengtsson, C.

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of medicine & science in sports 1 (1991), S. 0

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ISSN: 1600-0838

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine , Sports Science

Notes: Physical perfomance was studied uniformly after intake of different antihypertensive drugs, and a comparison was made with placebo. The time needed to run 5000 m was studied in a nonhypertensive subject. In one of the different study periods, heart rate was continuously recorded during and after exercise. Physical perfomance was significantly reduced when a β-blocker was taken. The effect on physical capacity was strongly dose-dependent. With a high but conventional dose of a β-blocker, the time needed to run 5000 m was increased by more than 33%. No differences were observed between types of β-blockers. Physical capacity was slightly but significantly impaired when an α-blocker was taken; no differences in physical capacity between the drugs used and placebo were observed for a diuretic, a calcium antagonist or an inhibitor of the angiotensin-converting enzyme. The reduced physical perfomance seems to be caused by a reduction of the maximal heart rate as a result of the β-blockade. Thus, heart rate did not exceed 120 beats/min when the subject ran at maximal long-distance speed after intake of 100 mg of metoprolol, as recorded by continuous heart rate registration.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-0838.1991.tb00270.x

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Follow-up study of participants in an extensive health examination programme at a Swedish industry (1991)

Rose, G. ; Bengtsson, C.

Springer

Journal of molecular medicine 69 (1991), S. 1146-1151

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ISSN: 1432-1440

Keywords: Health control ; Health promotion ; Prevention ; Laboratory examinations ; Evaluation ; Occupational medicine

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Two years after an extensive health examination at a Swedish industry, a follow-up study was carried out in 110 employees (94% of those initially examined). The control included a history of the subject's health, a physical examination, an electrocardiogram, urine and faeces examinations and 16 chemical analyses of whole blood or serum. Except for repeat examinations of those who had had initial values outside reference values, most of the chemical analyses meant nothing, leading to unnecessary expense and possible risk of either worried or complacent participants. The history and physical and laboratory examinations, aimed at finding factors which can be improved by changing the life style seem to be most beneficial. It is concluded that extensive health examinations, including a large number of laboratory examinations which are carried out at many industries as a health control, should be critically evaluated at these industries.