ISSN:
1432-1041
Keywords:
Dextromethorphan
;
oxidative phenotype
;
Burundi
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The wide availability, metabolism by the same cytochrome P 450 as debrisoquine and, above all, the innocuity of dextromethorphan (DMP) favour the frequent choice of this drug as the test substance in determining oxidation phenotypes. 100 healthy Burundian volunteers (94 m and 6 f) in this study ingested 50 mg DMP bromhydrate, i.e. 38.5 mg of DMP base. Urine was collected for 8 h following the dose and TLC was used to analyse it. The method was particularly useful in view of its low cost, speed and the ease of applying it to a large study group. 5% of the Burundian subjects were poor metabolizers.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00280112
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