Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Dosing and side-effects of ifosfamide plus mesna (1991)
    Springer
    Journal of cancer research and clinical oncology 117 (1991), S. S164 
    Details
    ISSN: 1432-1335
    Keywords: Ifosfamide plus mesna ; Toxicity ; Continuous infusion ; Short-term infusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In clinical practice and in most ongoing studies in adult and pediatric tumours, daily short-time infusions of ifosfamide (IFO) on 2–5 consecutive days with cycle doses between 6 g/m2 and 12 g/m2 are used at present. The continuous i.v. infusion of IFO/mesna over 1–5 days is still experimental. Since mesna prevents IFO-induced urotoxicity, the IFO dose could be increased to 16 g/m2 per cycle. As the dose and schedules of IFO/ mesna were increased and varied, CNS and renal toxicity became more evident. CNS toxicity seems not to be dependent on i.v., but on oral dosing of IFO. Renal dysfunction and previous administration of cisplatinum predispose for CNS toxicity. The incidence or severity of CNS toxicity does not increase with subsequent courses of IFO i.v. The nephrotoxicity of IFO is dependent on IFO dose, diuresis, mesna dose and whether there has been previous cisplatinum and seems to involve preferentially the tubulus system, leading to 25 cases of Fanconi renal syndrome as published in 1988–1990. Fanconi's syndrome depends on the cumulative IFO dose, the previous administration of nephrotoxic drugs such as cisplatinum and the age of the children. Studies are continuing to determine the least nephrotoxic dose and schedule of IFO plus mesna. Leucopenia and thrombopenia are well-known dose-dependent side-effects of IFO, with similar incidence after i.v. short-time and continuous infusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01613224
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    In vitro reconstitution of U1 and U2 snRNPs from isolated proteins and snRNA (1992)
    Springer
    Molecular biology reports 16 (1992), S. 229-240 
    Details
    ISSN: 1573-4978
    Keywords: U snRNPs ; in vitro reconstitution ; RNA-protein interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In this paper we describe a method for preparing native, RNA-free, proteins from anti-m3G purified snRNPs (U1, U2, U4/U6 and U5) and the subsequent quantitative reconstitution of U1 and U2 snRNPs from purified proteins and snRNA. Reconstituted U1 and U2 snRNPs contained the full complement of core proteins, B, B′, D1, D2, D3, E, F and G. Both the U1 and U2 reconstituted particles were stable in CsCl gradients and had the expected buoyant density of 1.4 g/cm3. Reconstituted RNP particle formation was not competited by a 50 fold molar excess of tRNA, as determined by gel retardation assays. However, U1 and U2 particle formation was reduced in the presence of an excess of cold U1 or U2 snRNA demonstrating a specific RNA-protein interaction. U1 and U2 snRNPs were also efficiently reconstituted in vitro, utilizing proteins prepared from mono Q purified U1 and U2 snRNPs. This suggests that for the assembly of snRNPs in vitro no auxiliary proteins other than bona fide snRNP proteins appear to be required. The potential of this reconstitution technique for investigating snRNP assembly and snRNA-protein interactions is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00419662
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of spermatogenesis and spermatozoa of Cephalodasys maximus (Gastrotricha, Macrodasyida) (1994)
    Springer
    Zoomorphology 114 (1994), S. 213-225 
    Details
    ISSN: 1432-234X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Spermatogenesis and sperm ultrastructure of the macrodasyidan gastrotrich Cephalodasys maximus are described by means of transmission electron microscopy. The filiform sperm consists of an acrosomal accessory structure and an acrosomal vesicle, both being surrounded by spiralled material. The successive nuclear helix encloses the spiral-shaped mitochondrion and the axoneme of the flagellum is accompanied by dense strings, three helical elements and peripheral microtubules. During spermiogenesis the acrosomal accessory structure develops first and moves into a cell projection, where the spiral around this acrosomal rod forms. A nuclear section with condensed chromatin and one single fused large mitochondrion follow into the extension, becoming helical. A connecting clasp between nucleus and flagellum shortens to a cap-like structure. Parallel to the acrosomal and nuclear projection the flagellum develops where the spiralled elements and the basal plate form in succession, while the basal body shrinks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00416860
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Phylogenetic relationships ofBacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase β-subunit genes (1993)
    Springer
    Antonie van Leeuwenhoek 64 (1993), S. 285-305 
    Details
    ISSN: 1572-9699
    Keywords: ATP synthase β-subunit ; Bacteria ; elongation factor Tu ; phylogeny ; sequence analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Comparative sequence analyses were performed on 14 genes encoding bacterial elongation factors EF-Tu and 7 genes encoding the β-subunit of bacterial F1F0 type ATP-synthases. The corresponding predicted amino acid sequences were compared with published primary structures of homologous molecules. Phylogenetic trees were reconstructed from both data sets of aligned protein sequences and from an equivalent selection of 16S rRNA sequences by applying distance matrix and maximum parsimony methods. The EF-Tu data were in very good agreement with the rRNA data, although the resolution within the EF-Tu tree was reduced at certain phylogenetic levels. The resolution power of the ATPase β-subunit sequence data were more reduced than those of the EF-Tu data. In comparison with the 16S rRNA tree there are minor differences in the order of adjacent branchings within the ATPase β-subunit tree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00873088
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...